Query   'D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'  matched   26 Records

Record No : 1

Instance ID10259
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePPDLS
Bait Uniprot AccessionP17789
Bait Uniprot IdentifierTTKB_DROME
Bait Gene Namettk
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position593-597
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20259
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10978285
CommentsThe PxDLS CtBP ligand motif in Drosophila repressor protein Tramtrack p69 (Ttk69) that is critical for mediating interaction with the Drosophila homolog of C-terminal-binding protein (dCtBP) and essential for Ttk69 function

Record No : 2

Instance ID10260
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstanceGLDLSK
Bait Uniprot AccessionQ14526
Bait Uniprot IdentifierHIC1_HUMAN
Bait Gene NameHIC1
Bait OrganismHomo sapiens (Human)
Sequence Position241-246
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20260
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12052894
CommentsThe human candidate tumor suppressor gene HIC1 recruits CtBP through a conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine

Record No : 3

Instance ID10261
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePVDLS
Bait Uniprot AccessionO95600
Bait Uniprot IdentifierKLF8_HUMAN
Bait Gene NameKLF8
Bait OrganismHomo sapiens (Human)
Sequence Position86-90
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down
Interaction ID20261
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10756197
CommentsHuman Kr├╝ppel-like factor 8 contains a Pro-Val-Asp-Leu-Ser/Thr motif that mediates contact with the co-repressor protein C-terminal Binding Protein (CtBP) and represses transcription

Record No : 4

Instance ID10262
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ99708
Bait Uniprot IdentifierCOM1_HUMAN
Bait Gene NameRBBP8
Bait OrganismHomo sapiens (Human)
Sequence Position490-494
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Competition binding
Interaction ID20262
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)E1A exon 2 peptide
Reference(s)9535825
CommentsHuman CtBP was found to specifically interact with human CtIP (CtBP-interacting protein) or DNA endonuclease RBBP8 through a conserved PLDLS motif and the CtBP-CtIP complex is disrupted by E1A resulting in tumorigenesis-restraining activity

Record No : 5

Instance ID10263
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ64318
Bait Uniprot IdentifierZEB1_MOUSE
Bait Gene NameZeb1
Bait OrganismMus musculus (Mouse)
Sequence Position712-716
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20263
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10567582
CommentsThe PxDLS motif in mouse zinc finger-homeodomain factor Delta EF1 that serve as the site for interaction with mouse CtBP1

Record No : 6

Instance ID10264
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ64318
Bait Uniprot IdentifierZEB1_MOUSE
Bait Gene NameZeb1
Bait OrganismMus musculus (Mouse)
Sequence Position712-716
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20264
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10567582
CommentsThe PxDLS motif in mouse zinc finger-homeodomain factor Delta EF1 that serve as the site for interaction with mouse CtBP2

Record No : 7

Instance ID10265
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePMDLS
Bait Uniprot AccessionP10734
Bait Uniprot IdentifierKNIR_DROME
Bait Gene Namekni
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position331-335
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20265
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9843507
CommentsDrosophila CtBP interacts with Zygotic gap protein knirps through the PxDLS motif is essential for the repression activity of this protein in transgenic embryos

Record No : 8

Instance ID10266
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePIDLS
Bait Uniprot AccessionP48552
Bait Uniprot IdentifierNRIP1_HUMAN
Bait Gene NameNRIP1
Bait OrganismHomo sapiens (Human)
Sequence Position440-444
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20266
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11509661
CommentsThe PxDLS motif in human Nuclear factor RIP140 that serves as the site for interaction with the transcriptional corepressor CtBP

Record No : 9

Instance ID10267
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLS
Bait Uniprot AccessionP35712
Bait Uniprot IdentifierSOX6_HUMAN
Bait Gene NameSOX6
Bait OrganismHomo sapiens (Human)
Sequence Position424-428
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20267
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11504872
CommentsThe PxDLS motif in human transcription factor SOX-6 that serves as the site for interaction with the transcriptional corepressor CtBP

Record No : 10

Instance ID10268
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ15583
Bait Uniprot IdentifierTGIF1_HUMAN
Bait Gene NameTGIF1
Bait OrganismHomo sapiens (Human)
Sequence Position153-157
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20268
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Holoprosencephaly
Inhibitor(s)Unknown
Reference(s)10995736
CommentsThe homeodomain protein TGIF1 interacts with the transcriptional corepressor CtBP via the PxDLS motif

Record No : 11

Instance ID10269
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePIDLR
Bait Uniprot AccessionQ91647
Bait Uniprot IdentifierQ91647_XENLA
Bait Gene Namecbx4
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position455-459
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID20269
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9858600
CommentsXenopus homolog of C-terminal binding protein 1 (XCtBP1) interacts with Xenopus Pc (XPc), homolog of the Drosophila PcG protein Pc, through the PxDLS motif

Record No : 12

Instance ID10270
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLT
Bait Uniprot AccessionQ96JN0
Bait Uniprot IdentifierLCOR_HUMAN
Bait Gene NameLCOR
Bait OrganismHomo sapiens (Human)
Sequence Position64-68
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20270
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12535528
CommentsLigand-dependent nuclear receptor corepressor LCoR interacts with the transcriptional corepressor CtBP via the PxDLS motif

Record No : 13

Instance ID10271
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePIDLR
Bait Uniprot AccessionO00257
Bait Uniprot IdentifierCBX4_HUMAN
Bait Gene NameCBX4
Bait OrganismHomo sapiens (Human)
Sequence Position472-476
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20271
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9858600
CommentsThe C-terminal fragment of human Pc 2 (HPC2), homolog of the Drosophila PcG protein Pc, to which human CtBP2 binds

Record No : 14

Instance ID10272
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLA
Bait Uniprot AccessionQ9UHF7
Bait Uniprot IdentifierTRPS1_HUMAN
Bait Gene NameTRPS1
Bait OrganismHomo sapiens (Human)
Sequence Position1163-1167
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20272
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12444977
CommentsIkaros-related protein TRPS1 contains a PXDLS CtBP contact motif within its repression domain for binding to murine CtBP2

Record No : 15

Instance ID10273
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLSLT
Bait Uniprot AccessionP70062
Bait Uniprot IdentifierT7L1A_XENLA
Bait Gene Nametcf7l1-a
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position469-473
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20273
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10375506
CommentsXenopus homolog of C-terminal binding protein 1 (XCtBP1) interacts with Xenopus HMG box transcription factor TCF-3-A through the carboxy-terminal PxDLS motif (469-473)

Record No : 16

Instance ID10274
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLSLV
Bait Uniprot AccessionP70062
Bait Uniprot IdentifierT7L1A_XENLA
Bait Gene Nametcf7l1-a
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position545-549
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20274
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10375506
CommentsXenopus homolog of C-terminal binding protein 1 (XCtBP1) interacts with Xenopus HMG box transcription factor TCF-3-A through the carboxy-terminal PxDLS motif (545-549)

Record No : 17

Instance ID10275
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionO60315
Bait Uniprot IdentifierZEB2_HUMAN
Bait Gene NameZEB2
Bait OrganismHomo sapiens (Human)
Sequence Position815-819
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20275
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12714599
CommentsInteraction between human Smad-interacting protein-1 (ZEB2) and the corepressor C-terminal binding protein (CTBP1) through conserved PXDLS-like motif (815-819)

Record No : 18

Instance ID10276
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLS
Bait Uniprot AccessionO60315
Bait Uniprot IdentifierZEB2_HUMAN
Bait Gene NameZEB2
Bait OrganismHomo sapiens (Human)
Sequence Position785-789
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20276
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12714599
CommentsInteraction between human Smad-interacting protein-1 (ZEB2) and the corepressor C-terminal binding protein (CTBP1) through conserved PXDLS-like motif (785-789)

Record No : 19

Instance ID10277
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLT
Bait Uniprot AccessionO60315
Bait Uniprot IdentifierZEB2_HUMAN
Bait Gene NameZEB2
Bait OrganismHomo sapiens (Human)
Sequence Position859-863
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20277
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12714599
CommentsInteraction between human Smad-interacting protein-1 (ZEB2) and the corepressor C-terminal binding protein (CTBP1) through conserved PXDLS-like motif (859-863)

Record No : 20

Instance ID10278
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePEDLA
Bait Uniprot AccessionQ9H2S9
Bait Uniprot IdentifierIKZF4_HUMAN
Bait Gene NameIKZF4
Bait OrganismHomo sapiens (Human)
Sequence Position425-429
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20278
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12444977
CommentsIkaros family zinc finger protein Eos contains a PXDLS CtBP contact motif within its repression domain for binding to murine CtBP2

Record No : 21

Instance ID10279
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ03112
Bait Uniprot IdentifierEVI1_HUMAN
Bait Gene NameMECOM
Bait OrganismHomo sapiens (Human)
Sequence Position584-588
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20279
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Chronic myeloid leukemia
Inhibitor(s)Unknown
Reference(s)11965542
CommentsThe t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP through the PxDLS motif

Record No : 22

Instance ID10280
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionP28166
Bait Uniprot IdentifierZFH1_DROME
Bait Gene Namezfh1
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position786-790
Critical ResiduesP1; P2; P3; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20280
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10359772
CommentsDrosophila Zinc finger protein 1 (zfh-1), homologue of active transcriptional repressor ZEB, interacts with the corepressor CtBP to repress transcription through the PxDLS motif

Record No : 23

Instance ID10281
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLSLV
Bait Uniprot AccessionP14003
Bait Uniprot IdentifierHAIR_DROME
Bait Gene Nameh
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position318-322
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20281
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9524128
CommentsDrosophila CtBP interacts specifically and directly with a C-terminal PxDLS motif of the transcriptional repressor hairy (h)

Record No : 24

Instance ID10282
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLS
Bait Uniprot AccessionP41970
Bait Uniprot IdentifierELK3_HUMAN
Bait Gene NameELK3
Bait OrganismHomo sapiens (Human)
Sequence Position273-277
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20282
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10369679
CommentsmCtBP1 interacts strongly with Net, a negative Ras-switchable ternary complex factor, through its CtBP interaction domain (CID)

Record No : 25

Instance ID10283
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePEDLS
Bait Uniprot AccessionQ13422
Bait Uniprot IdentifierIKZF1_HUMAN
Bait Gene NameIKZF1
Bait OrganismHomo sapiens (Human)
Sequence Position34-38
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20283
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10766745
CommentsCtBP interacts with human DNA-binding protein Ikaros through a PEDLS motif present at the N terminus of Ikaros

Record No : 26

Instance ID10284
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionP03254
Bait Uniprot IdentifierE1A_ADE02
Bait Gene NameNot Available
Bait OrganismHuman adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Sequence Position279-283
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Pull down; Co-IP; Mutation analysis
Interaction ID20284
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)7479821
CommentsC-terminal binding protein (CtBP) interacts with a conserved C-terminal motif of adenovirus E1A (exon 2), which may play a critical role in adenovirus replication and oncogenic transformation




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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)