The mitoPADdb is a manually curated database that provides comprehensive information on 810 mitochondrial protein-encoding (MPE) genes associated with 1793 disease terms. It contains information on mutations and expressional variations of MPE genes at both the mRNA and protein levels. The database classifies the diseases linked with mitochondrial proteins into 14 broad categories. It allows users to access the data using (I) by search option with Gene symbol or UniProt accession and (II) by browse options. The search option provides information about 18356 mutations, 1284 expressional variations (mRNA and protein levels) with experimental samples and techniques, and associated diseases with source identifiers. The browse option allows users to access these data along with disease-gene-pathway links and differential genes’ expression heatmap across 317 disease studies, in five ways: 1) Gene symbol, 2) Pathway name, 3) Disease category name, 4) Disease category-wise MPE gene expression heatmap, and 5) Disease category-pairwise comparison of MPE gene expression heatmap.

Cite as: Das, J., Bhattacharjee, S., & Saha, S. (2024). mitoPADdb: A database of mitochondrial proteins associated with diseases. Mitochondrion, 78, 101927. https://doi.org/10.1016/j.mito.2024.101927 Available online at: https://authors.elsevier.com/c/1jLyP5aTPdCrfI (This link is valid till August 20, 2024).

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