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LncRNAs are noncoding transcripts longer than 200 nucleotides.They are actively transcribed from the cell from different genomic locations as shown below
LncRNAs are involved in multiple cellular regulatory processes, ranging from X chromosome inactivation, genomic imprinting and chromatin modification, to telomere elongation, transcriptional activation and nuclear trafficking.
LncRNAs are poorly conserved between species and show tissue-specific expression pattern.
LncRNAs play a role in the development and pathophysiology of disease. LncRNAs are expressed in various types of cancer including leukemia, breast cancer, hepatocellular carcinoma, colon cancer, and prostate cancer.