Query 'PTB domain' matched 49 Records
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Record No : 1 |
| Instance ID | 10735 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 756-763 | | Critical Residues | P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis; SPR; X-ray crystallography | | Interaction ID | 20735 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The phosphotyrosine-binding domain (PTB) of the human adaptor protein X11alpha/MINT1/APBA1 binds to the the NPxY PTB-binding motif of Human amyloid precursor protein (APP) |
Record No : 2 |
| Instance ID | 10736 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 756-763 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; X-ray crystallography; ITC | | Interaction ID | 20736 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The interaction of the C-terminal phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY PTB-binding motif of human amyloid precursor protein (APP), mediates APP trafficking and signalling, and is thought to regulate APP processing |
Record No : 3 |
| Instance ID | 10737 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 756-763 | | Critical Residues | P1; P2; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Filter binding assay; Fluorescence anisotropy; Y2H | | Interaction ID | 20737 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The amino-terminal phosphotyrosine-binding (PTB) domain of human Disabled homolog 1 (DAB1) binds specifically to the transmembrane glycoproteins of the human amyloid precursor protein (APP) through the NPXY motif but does not bind to tyrosine-phosphorylated peptide ligands |
Record No : 4 |
| Instance ID | 10738 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TGENPIYK | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 777-784 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20738 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (777-784) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Disabled homolog 1 (Dab1) |
Record No : 5 |
| Instance ID | 10739 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TGENPIYK | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 777-784 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20739 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (777-784) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) |
Record No : 6 |
| Instance ID | 10740 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TGENPIYK | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 777-784 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20740 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (777-784) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Talin-1 (Tln1) |
Record No : 7 |
| Instance ID | 10741 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | QDSNPLYK | | Bait Uniprot Accession | P26010 | | Bait Uniprot Identifier | ITB7_HUMAN | | Bait Gene Name | ITGB7 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-779 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20741 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (772-779) in human Integrin beta-7 (ITGB7) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Docking protein 1 (Dok1) |
Record No : 8 |
| Instance ID | 10742 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | QDSNPLYK | | Bait Uniprot Accession | P26010 | | Bait Uniprot Identifier | ITB7_HUMAN | | Bait Gene Name | ITGB7 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-779 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20742 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (772-779) in human Integrin beta-7 (ITGB7) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of human Tensin-like C1 domain-containing phosphatase (TENC1) |
Record No : 9 |
| Instance ID | 10743 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | QDSNPLYK | | Bait Uniprot Accession | P26010 | | Bait Uniprot Identifier | ITB7_HUMAN | | Bait Gene Name | ITGB7 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-779 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20743 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (772-779) in human Integrin beta-7 (ITGB7) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Talin-1 (Tln1) |
Record No : 10 |
| Instance ID | 10744 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P08592 | | Bait Uniprot Identifier | A4_RAT | | Bait Gene Name | App | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 756-763 | | Critical Residues | P2; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20744 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12826668 | | Comments | Interaction of the phosphotyrosine-binding (PTB) domain of mouse Disabled homolog 1 (Dab1) with the NPXY motif of the rat amyloid precursor protein (App) |
Record No : 11 |
| Instance ID | 10745 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P12023 | | Bait Uniprot Identifier | A4_MOUSE | | Bait Gene Name | App | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 756-763 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | ITC; Mutation analysis; NMR | | Interaction ID | 20745 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18650440 | | Comments | Interaction of the C-terminal phosphotyrosine-binding (PTB) domain of the mouse adaptor protein Fe65L1/Apbb2 with the NPxY PTB-binding motif of mouse amyloid precursor protein (App) |
Record No : 12 |
| Instance ID | 10746 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TVVNPKYE | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 789-796 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Alanine scanning; Pull down; Y2H | | Interaction ID | 20746 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11741908 | | Comments | Interaction between the phosphotyrosine-binding (PTB) domain of human ICAP1 alpha and the NPXY motif (789-796) of human Integrin beta-1 |
Record No : 13 |
| Instance ID | 10747 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | NFDNPVYR | | Bait Uniprot Accession | Q14114 | | Bait Uniprot Identifier | LRP8_HUMAN | | Bait Gene Name | LRP8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 860-867 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; Pull down; X-ray crystallography | | Interaction ID | 20747 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12737822 | | Comments | Interaction between the phosphotyrosine binding (PTB) domain of the Mouse adaptor protein Disabled-1 (Dab1) and the NPXY motif of human Reelin, the very low-density lipoprotein receptor, the Apolipoprotein E receptor 2 (APOER2/LRP8) |
Record No : 14 |
| Instance ID | 10748 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TANNPLYK | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 767-774 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography; Mutation analysis; NMR | | Interaction ID | 20748 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12535520, 18156175 | | Comments | The NPxY motif (767-774) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of chicken Talin-1 (TLN1) |
Record No : 15 |
| Instance ID | 10749 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | EIGNPTYK | | Bait Uniprot Accession | Q07954 | | Bait Uniprot Identifier | LRP1_HUMAN | | Bait Gene Name | LRP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 4467-4474 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; Knock out | | Interaction ID | 20749 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 15115822, 16382151 | | Comments | The interaction of the phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY motif (4467-4474) of human Apolipoprotein E receptor LRP1 whereby FE65 acts as a functional linker between APP and LRP |
Record No : 16 |
| Instance ID | 10750 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | EFQNPLYS | | Bait Uniprot Accession | Q9XWD6 | | Bait Uniprot Identifier | CED1_CAEEL | | Bait Gene Name | ced-1 | | Bait Organism | Caenorhabditis elegans | | Sequence Position | 959-966 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP | | Interaction ID | 20750 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11729193 | | Comments | The PTB Domain of Cell death protein 6 (ced-6), an adapter protein of Caenorhabditis elegans, binds to the NPXY motif of Cell death abnormality protein 1 (ced-1) |
Record No : 17 |
| Instance ID | 10751 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | NFTNPVYA | | Bait Uniprot Accession | Q07954 | | Bait Uniprot Identifier | LRP1_HUMAN | | Bait Gene Name | LRP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 4501-4508 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 20751 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 15115822 | | Comments | The interaction of the phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY motif (4501-4508) of human Apolipoprotein E receptor LRP1 whereby FE65 acts as a functional linker between APP and LRP |
Record No : 18 |
| Instance ID | 10752 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | NFDNPVYQ | | Bait Uniprot Accession | P01130 | | Bait Uniprot Identifier | LDLR_HUMAN | | Bait Gene Name | LDLR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 822-829 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Y2H | | Interaction ID | 20752 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9837937 | | Comments | Interaction between the phosphotyrosine binding (PTB) domain of the Mouse adaptor protein Disabled-1 (Dab1) and the NPXY motif of human Low-density lipoprotein receptor (LDLR) |
Record No : 19 |
| Instance ID | 10753 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | VFTNAAFD | | Bait Uniprot Accession | P16109 | | Bait Uniprot Identifier | LYAM3_HUMAN | | Bait Gene Name | SELP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 820-827 | | Critical Residues | P2; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H; SPR | | Interaction ID | 20753 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19138666 | | Comments | The N-terminal phosphotyrosine-binding (PTB) domain of Human Numb3 (NUMB) binds to the cytosolic tail of the leukocyte adhesion receptor P-selectin (SELP) |
Record No : 20 |
| Instance ID | 10754 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GLDNPAYV | | Bait Uniprot Accession | Q8TBB1 | | Bait Uniprot Identifier | LNX1_HUMAN | | Bait Gene Name | LNX1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 178-185 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Co-IP; Pull down; Y2H; Competition binding | | Interaction ID | 20754 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9846878, 9535908 | | Comments | High-affinity binding of the Drosophila Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of human E3 ubiquitin-protein ligase LNX1 |
Record No : 21 |
| Instance ID | 10755 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GFSNMSFE | | Bait Uniprot Accession | Q9U485 | | Bait Uniprot Identifier | Q9U485_DROME | | Bait Gene Name | Nak | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 1439-1446 | | Critical Residues | P2; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Alanine scanning | | Interaction ID | 20755 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10747019 | | Comments | High-affinity binding of the Drosophila Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of Drosophila Numb-associated kinase (Nak) |
Record No : 22 |
| Instance ID | 10756 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | SVPNPVFG | | Bait Uniprot Accession | Q9NY15 | | Bait Uniprot Identifier | STAB1_HUMAN | | Bait Gene Name | STAB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 2536-2543 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Pull down; Alanine scanning | | Interaction ID | 20756 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20599701 | | Comments | The PTB domain of human adapter protein GULP is able to specifically interact with the NPxF/Y motif of human phagocytic receptor Stabilin-1 (STAB1) cytoplasmic region thus functioning as an adaptor protein for Stabilin-1-mediated phagocytosis |
Record No : 23 |
| Instance ID | 10757 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | LLSNPTY | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Bait Organism | Murine polyomavirus (strain A2) (MPyV) | | Sequence Position | 244-250 | | Critical Residues | P2; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Alanine scanning | | Interaction ID | 20757 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7543098 | | Comments | Phosphorylation of Y250 in the PTB-binding NPxY motif of Middle T antigen of Murine polyomavirus induces binding to the PTB domain of human SHC-transforming protein 1 (SHC1) |
Record No : 24 |
| Instance ID | 10758 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | IIENPQY | | Bait Uniprot Accession | P04629 | | Bait Uniprot Identifier | NTRK1_HUMAN | | Bait Gene Name | NTRK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 490-496 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | ITC; Mutation analysis; NMR | | Interaction ID | 20758 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8524391 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif of human Neurotrophic tyrosine kinase receptor type 1 (NTRK1) |
Record No : 25 |
| Instance ID | 10759 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | LHPNPMY | | Bait Uniprot Accession | Q61006 | | Bait Uniprot Identifier | MUSK_MOUSE | | Bait Gene Name | Musk | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 547-553 | | Critical Residues | P1; P2; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Protein kinase assay; X-ray crystallography | | Interaction ID | 20759 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20603078 | | Comments | The mouse cytoplasmic adaptor protein Dok7 activates the mouse Muscle-specific tyrosine-protein kinase receptor Musk via interaction of its phosphotyrosine-binding (PTB) domain with a phosphopeptide motif in Musk |
Record No : 26 |
| Instance ID | 10760 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | TANNPLY | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 767-773 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Alanine scanning; SPR | | Interaction ID | 20760 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18156175, 20739287, 12606711 | | Comments | The phosphotyrosine binding (PTB) domain of human Docking protein 1 (DOK1) binds to tyrosine-phosphorylated NPxY motif of human Integrin beta-3 (ITGB3) |
Record No : 27 |
| Instance ID | 10761 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | TANNPLY | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 767-773 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Alanine scanning; SPR | | Interaction ID | 20761 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18156175, 20739287, 12606711 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (767-773) of human Integrin beta-3 (ITGB3) |
Record No : 28 |
| Instance ID | 10762 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | SVQNPVY | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1104-1110 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20762 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15476828 | | Comments | Phosphotyrosine binding (PTB) domains of the Human adaptor protein DOK1 specifically associates with the tyrosine-phosphorylated NPxY motif (1104-1110) of human Epidermal growth factor receptor (EGFR) |
Record No : 29 |
| Instance ID | 10763 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | EIINPNY | | Bait Uniprot Accession | Q92835 | | Bait Uniprot Identifier | SHIP1_HUMAN | | Bait Gene Name | INPP5D | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 909-915 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20763 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9083021 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (909-915) of human SH2-containing inositol phosphatase (SHIP/INPP5D) |
Record No : 30 |
| Instance ID | 10764 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | IAGNPAY | | Bait Uniprot Accession | P24394 | | Bait Uniprot Identifier | IL4RA_HUMAN | | Bait Gene Name | IL4R | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 491-497 | | Critical Residues | P1; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis; ITC; NMR | | Interaction ID | 20764 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8599766 | | Comments | The PTB domain of human Insulin receptor substrate 1 (IRS1) can recognize and bind specifically to phosphotyrosine-containing NPxY motif of human Interleukin-4 receptor subunit alpha |
Record No : 31 |
| Instance ID | 10765 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | TFTNITY | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 779-785 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Mutation analysis | | Interaction ID | 20765 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20739287 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (779-785) of human Integrin beta-3 (ITGB3) |
Record No : 32 |
| Instance ID | 10766 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | WIENKLY | | Bait Uniprot Accession | P35546 | | Bait Uniprot Identifier | RET_MOUSE | | Bait Gene Name | Ret | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1057-1063 | | Critical Residues | P1; P6; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | SPR; X-ray crystallography | | Interaction ID | 20766 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14607833 | | Comments | The N-terminal phosphotyrosine binding (PTB) domain of Mouse Dok1 can recognize and bind specifically to phosphotyrosine-containing NPxY motif of Mouse Proto-oncogene tyrosine-protein kinase receptor Ret |
Record No : 33 |
| Instance ID | 10767 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | CFTNQGY | | Bait Uniprot Accession | P14784 | | Bait Uniprot Identifier | IL2RB_HUMAN | | Bait Gene Name | IL2RB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 358-364 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 20767 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8643566 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Interleukin-2 receptor subunit beta (IL2RB) |
Record No : 34 |
| Instance ID | 10768 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | LLPNHSY | | Bait Uniprot Accession | P16144 | | Bait Uniprot Identifier | ITB4_HUMAN | | Bait Gene Name | ITGB4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1590-1596 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 20768 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11044453 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Integrin beta-4 (ITGB4) |
Record No : 35 |
| Instance ID | 10769 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | MFENPLY | | Bait Uniprot Accession | Q92835 | | Bait Uniprot Identifier | SHIP1_HUMAN | | Bait Gene Name | INPP5D | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1016-1022 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Pull down; Protein kinase assay; Mutation analysis | | Interaction ID | 20769 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9099679 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (1016-1022) of human SH2-containing inositol phosphatase (SHIP/INPP5D) |
Record No : 36 |
| Instance ID | 10770 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | ASSNPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 993-999 | | Critical Residues | P4; P5; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Protein kinase assay; Y2H; Alanine scanning | | Interaction ID | 20770 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8626723 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Insulin receptor (INSR) |
Record No : 37 |
| Instance ID | 10771 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | ASSNPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 993-999 | | Critical Residues | P4; P5; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20771 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8626723 | | Comments | The phosphotyrosine-binding (PTB) domain of human Insulin receptor substrate 1 (IRS1) interacts with the tyrosine-phosphorylated NPxY motif of human Insulin receptor (INSR) |
Record No : 38 |
| Instance ID | 10772 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | SLDNPDY | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1166-1172 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20772 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15476828 | | Comments | Phosphotyrosine binding (PTB) domains of the Human adaptor protein DOK1 specifically associates with the tyrosine-phosphorylated NPxY motif (1166-1172) of human Epidermal growth factor receptor (EGFR) |
Record No : 39 |
| Instance ID | 10773 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | AFDNPDY | | Bait Uniprot Accession | P21860 | | Bait Uniprot Identifier | ERBB3_HUMAN | | Bait Gene Name | ERBB3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1322-1328 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Protein kinase assay; Mutation analysis | | Interaction ID | 20773 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8026468 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Proto-oncogene-like protein c-ErbB-3 (ERBB3) |
Record No : 40 |
| Instance ID | 11933 | | Regular Expression | NPxY | | Motif Instance | NPAY | | Bait Uniprot Accession | P24394 | | Bait Uniprot Identifier | IL4RA_HUMAN | | Bait Gene Name | IL4R | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 494-497 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21933 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8599766, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Interleukin-4 receptor subunit alpha that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1) |
Record No : 41 |
| Instance ID | 11934 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P08069 | | Bait Uniprot Identifier | IGF1R_HUMAN | | Bait Gene Name | IGF1R | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 977-980 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21934 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7541045, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin-like growth factor 1 receptor (IGF1R) that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1) |
Record No : 42 |
| Instance ID | 11935 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 996-999 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21935 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7537849, 7935368 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin receptor that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1) |
Record No : 43 |
| Instance ID | 11936 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 996-999 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21936 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin receptor that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 44 |
| Instance ID | 11937 | | Regular Expression | NPxY | | Motif Instance | NPQY | | Bait Uniprot Accession | P04629 | | Bait Uniprot Identifier | NTRK1_HUMAN | | Bait Gene Name | NTRK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 493-496 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21937 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8226808, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of High affinity nerve growth factor receptor (NTRK1) that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 45 |
| Instance ID | 11938 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P08069 | | Bait Uniprot Identifier | IGF1R_HUMAN | | Bait Gene Name | IGF1R | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 977-980 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21938 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7541045, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin-like growth factor 1 receptor (IGF1R) that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 46 |
| Instance ID | 11939 | | Regular Expression | NPxY | | Motif Instance | NPDY | | Bait Uniprot Accession | P21860 | | Bait Uniprot Identifier | ERBB3_HUMAN | | Bait Gene Name | ERBB3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1325-1328 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21939 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8026468, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Receptor tyrosine-protein kinase erbB-3 that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 47 |
| Instance ID | 11940 | | Regular Expression | NPxY | | Motif Instance | NPTY | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Bait Organism | Murine polyomavirus (strain A2) (MPyV) | | Sequence Position | 247-250 | | Critical Residues | P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21940 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8022784, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Middle T antigen of Murine polyomavirus that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 48 |
| Instance ID | 11941 | | Regular Expression | NPxY | | Motif Instance | NPDY | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1169-1172 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay; Dephosphorylation protection assay | | Interaction ID | 21941 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7542744, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Epidermal growth factor receptor that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 49 |
| Instance ID | 11986 | | Regular Expression | NPx[FY] | | Motif Instance | NPAY | | Bait Uniprot Accession | O70263 | | Bait Uniprot Identifier | LNX1_MOUSE | | Bait Gene Name | Lnx1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 185-188 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21986 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9535908 | | Comments | High-affinity binding of the Mouse Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of mouse E3 ubiquitin-protein ligase Lnx1 |
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