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BROWSE RESULT OF Epigenetics

16 Records

 

Record No:1


ACCESS NO100608
GENERunx3
DESCRIPTIONRunt-related transcription factor 3
NCBI ENTREZ ACCESS NO12399
UNIPROT ACCESS NOQ3U1Q3
ORGANISMMouse
SAMPLELung Tissue
TECHNIQUESMethylation-specific PCR and MALDI-TOF 
OMICSEpigenetics
STUDY Low Throughput
COMMENTSNegative regulator of allergic disorders but suppressed in progeny due to high methylation if exposed to a methyl rich diet.
GEO_PRIDE_ACCESS_NON/A
REFERENCE18802477
DRUG TARGET
MONCLONAL ANTIBODYAnti-RUNX1/AML1+RUNX3+RUNX2 for Human/Mouse/Rat


Record No:2


ACCESS NO100609
GENEIFNG
DESCRIPTIONinterferon-gamma
NCBI ENTREZ ACCESS NO3458
UNIPROT ACCESS NOP01579
ORGANISMHuman
SAMPLET cells from peripheral blood
TECHNIQUESbisulphite-specific polymerase chain reaction (PCR
OMICSEpigenetics
STUDY Low Throughput
COMMENTSExposure to smoke and ambient air pollution leads to hypermethylation and thereby decreased expression of IFN gamma.
GEO_PRIDE_ACCESS_NON/A
REFERENCE23009259
DRUG TARGETBE0000944
MONCLONAL ANTIBODYAnti-IFNGR1 for Human


Record No:3


ACCESS NO100610
GENEMT-CO2
DESCRIPTIONCyclooxygenase-2
NCBI ENTREZ ACCESS NO4513
UNIPROT ACCESS NOP00403
ORGANISMHuman
SAMPLEAirway epithelial cells
TECHNIQUESChIP and HDAC/HAT assay
OMICSEpigenetics
STUDY Low Throughput
COMMENTSLoss of HDAC1 increases cyclooxygenase expression during exposure to diesel exhaust particles.
GEO_PRIDE_ACCESS_NON/A
REFERENCE17395887
DRUG TARGETBE0003385
MONCLONAL ANTIBODYAnti-MTCO2 for Human


Record No:4


ACCESS NO100611
GENENOS2
DESCRIPTIONnitric oxide synthase 2
NCBI ENTREZ ACCESS NO4843
UNIPROT ACCESS NOP35228
ORGANISMHuman
SAMPLEBuccal-cell suspension
TECHNIQUESBisulphite-specific PCR and pyrosequencing
OMICSEpigenetics
STUDY Low Throughput
COMMENTSSeveral CPG loci in NOS genes are methylated suggesting alteration in expression.
GEO_PRIDE_ACCESS_NON/A
REFERENCE22591701
DRUG TARGETBE0000005
MONCLONAL ANTIBODYAnti-iNOS for Mouse/Rat


Record No:5


ACCESS NO100612
GENEACSL3
DESCRIPTIONacyl-CoA synthetase long-chain family member 3
NCBI ENTREZ ACCESS NO2181
UNIPROT ACCESS NOO95573
ORGANISMHuman
SAMPLEUmbilical cord white blood cells
TECHNIQUESMethylation specific PCR
OMICSEpigenetics
STUDY Low Throughput
COMMENTSMethylation of the ACSL3 5'-CGI is significantly associated with asthma in children.
GEO_PRIDE_ACCESS_NON/A
REFERENCE19221603
DRUG TARGETBE0001093
MONCLONAL ANTIBODYN/A


Record No:6


ACCESS NO100613
GENERAD50
DESCRIPTIONRAD50
NCBI ENTREZ ACCESS NO10111
UNIPROT ACCESS NOQ92878
ORGANISMHuman
SAMPLECord blood
TECHNIQUESbisulphite-specific polymerase chain reaction (PCR
OMICSEpigenetics
STUDY Low Throughput
COMMENTSHypermethylated in asthmatic children.
GEO_PRIDE_ACCESS_NON/A
REFERENCE23346934
DRUG TARGET
MONCLONAL ANTIBODYAnti-RAD50 for Human


Record No:7


ACCESS NO100614
GENEFOXP3
DESCRIPTIONforkhead box protein 3
NCBI ENTREZ ACCESS NO50943
UNIPROT ACCESS NOQ9BZS1
ORGANISMHuman
SAMPLET cells from peripheral blood
TECHNIQUESBisulphite-specific PCR and pyrosequencing
OMICSEpigenetics
STUDY Low Throughput
COMMENTSEssential for the development of T regulatory cells and is hypermethylated on exposure of ambient air pollution thus decreasing its expression.
GEO_PRIDE_ACCESS_NON/A
REFERENCE23009259
DRUG TARGET
MONCLONAL ANTIBODYAnti-FOXP3 for Rat/Human


Record No:8


ACCESS NO100615
GENEIl4
DESCRIPTIONinterleukin 4
NCBI ENTREZ ACCESS NO16189
UNIPROT ACCESS NOP07750
ORGANISMMouse
SAMPLECD4+ T cell
TECHNIQUESChip assay
OMICSEpigenetics
STUDY Low Throughput
COMMENTSHDAC1 directly controls the gene locus of IL4 and loss of HDAC1 leads to increased IL4.
GEO_PRIDE_ACCESS_NON/A
REFERENCE20702731
DRUG TARGET
MONCLONAL ANTIBODYAnti-IL4 for Human/Mouse/Monkey


Record No:9


ACCESS NO100616
GENEHdac1
DESCRIPTIONhistone deacetylase 1
NCBI ENTREZ ACCESS NO433759
UNIPROT ACCESS NOO09106
ORGANISMMouse
SAMPLECD4+ T cell
TECHNIQUESChip assay
OMICSEpigenetics
STUDY Low Throughput
COMMENTSLoss of HDAC1 leads to increased allergic symptoms.
GEO_PRIDE_ACCESS_NON/A
REFERENCE20702731
DRUG TARGETBE0002365
MONCLONAL ANTIBODYAnti HDAC1 antibody for human/mouse/ rat


Record No:10


ACCESS NO100617
GENEIl13
DESCRIPTIONinterleukin 13
NCBI ENTREZ ACCESS NO16163
UNIPROT ACCESS NOP20109
ORGANISMMouse
SAMPLECD4+ T cell
TECHNIQUESNucleofection with Let-7 miRNA
OMICSEpigenetics
STUDY High Throughput and Low Throughput
COMMENTSIL-13 is regulated by mmu-let-71.
GEO_PRIDE_ACCESS_NON/A
REFERENCE20630862
DRUG TARGETBE0002438
MONCLONAL ANTIBODYAnti-IL13 for Human


Record No:11


ACCESS NO100618
GENECCL11
DESCRIPTIONEotaxin
NCBI ENTREZ ACCESS NO6356
UNIPROT ACCESS NOP51671
ORGANISM Human
SAMPLEAirway smooth muscle cells
TECHNIQUESChip assay/western blotting/EMSA
OMICSEpigenetics
STUDY Low Throughput
COMMENTSIt is a major eosinophil chemoattractant whose gene expression is controlled by selective histone H4 acetylation on lysines 5 and 12 at the eotaxin promoter
GEO_PRIDE_ACCESS_NON/A
REFERENCE15972682
DRUG TARGETBE0003389
MONCLONAL ANTIBODYAnti-Eotaxin for Human


Record No:12


ACCESS NO100619
GENEIL2
DESCRIPTIONInterleukin2
NCBI ENTREZ ACCESS NO3558
UNIPROT ACCESS NOP60568
ORGANISMHuman
SAMPLECord blood
TECHNIQUESPyrosequencing
OMICSEpigenetics
STUDY Low Throughput
COMMENTSIncreasing methylation in cord blood of a functional CpG site in the IL-2 promoter is associated with increased likelihood of severe asthma exacerbations.
GEO_PRIDE_ACCESS_NON/A
REFERENCE23414538
DRUG TARGETBE0001029
MONCLONAL ANTIBODYAnti-IL2 for Human


Record No:13


ACCESS NO100620
GENEARG1
DESCRIPTIONArginase 1
NCBI ENTREZ ACCESS NO383
UNIPROT ACCESS NOP05089
ORGANISMHuman
SAMPLEBuccal mucosal cells
TECHNIQUESPyrosequencing
OMICSEpigenetics
STUDY Low Throughput
COMMENTSDNA methylation at the promoter of Arg1 is associated with exhaled nitric oxide- a well known biomarker of airway inflammation.
GEO_PRIDE_ACCESS_NON/A
REFERENCE21512169
DRUG TARGETBE0000286
MONCLONAL ANTIBODYN/A


Record No:14


ACCESS NO100621
GENEARG2
DESCRIPTIONArginase 2
NCBI ENTREZ ACCESS NO384
UNIPROT ACCESS NOP78540
ORGANISMHuman
SAMPLEBuccal mucosal cells
TECHNIQUESPyrosequencing
OMICSEpigenetics
STUDY Low Throughput
COMMENTSDifference in DNA methylation at the promoter of Arg1 controls the exhaled nitric oxide.
GEO_PRIDE_ACCESS_NON/A
REFERENCE21512169
DRUG TARGETBE0000758
MONCLONAL ANTIBODYAnti-ARG2 for Human/Rat


Record No:15


ACCESS NO100622
GENEALOX12
DESCRIPTIONarachidonate 12-lipoxygenase
NCBI ENTREZ ACCESS NO239
UNIPROT ACCESS NOP18054
ORGANISMHuman
SAMPLEcord blood DNA
TECHNIQUESPyrosequencing
OMICSEpigenetics
STUDY Low Throughput
COMMENTSHypomethylation at two CpGs of ALOX12 was significantly associated with persistent wheezing.
GEO_PRIDE_ACCESS_NON/A
REFERENCE22920181
DRUG TARGET
MONCLONAL ANTIBODYN/A


Record No:16


ACCESS NO100961
GENEMir21
DESCRIPTIONMicro RNA 21
NCBI ENTREZ ACCESS NO387140
UNIPROT ACCESS NO
ORGANISMMouse
SAMPLELung tissue
TECHNIQUESMicro RNA microarray and RT-PCR
OMICSEpigenetics
STUDY High Throughput
COMMENTSIt is a micro-RNA whose target is mIL-12p35. Decrease in mIL-12p35 leads to polarization TH cells to TH2 response.
GEO_PRIDE_ACCESS_NON/A
REFERENCE19342679
DRUG TARGET
MONCLONAL ANTIBODYN/A



© Bose Institute, Kolkata, 2014. All rights reserved. For technical queries regarding DAAB, contact Dr. Sudipto Saha at  ssaha4@jcbose.ac.in