Publication:

Sarkar, D., Jana, T., & Saha, S. LMPID: a manually curated database of linear motifs mediating protein-protein interactions. Database (2015) Vol. 2015: article ID bav014; doi:10.1093/database/bav014   PMID:25776024

Salient features of LMPID are:

  • It is a manually curated collection of LMs comprising of 1762 unique LM instances mediating 2215 PPIs among 1187 bait and 559 prey proteins.

  • It provides information about LM regular expressions, bait & prey protein UniProt ID and gene names, critical residues of the LM involved in the interaction and the interacting domain of the prey protein.

  • There are links to important biological resources like UniProt, PDB and PubMed.
Name of the Domain Number of interacting motif instances in LMPID
PDZ domain 274
SH3 domain 153
WW domain 156
AF-2 transcriptional activation domain 111
14-3-3 domain 100
EH domain 84
WD40 repeat domain 52
SH2 domain 50
PTB domain 49
EF hand 37
B domain 34
Hydrophobic cleft formed by subdomains 1 and 3 33
WH1 domain 33
Ankyrin repeat domain 32
MATH domain 29
Calcineurin-like phosphoesterase domain 26
C-terminal appendage domain 26
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 26
MLLE domain 26
Ligand-binding domain of nuclear hormone receptor 24
Homeodomain 22
PCNA, C-terminal domain 21
Conserved C-Terminal (CCT) domain 20
Protein kinase domain 20
Substrate-binding domain(SBD) of SINA/Siah proteins 19
Cyclin, N-terminal domain 18
UEV domain 18
PIF-binding pocket 17
Tetratricopeptide repeat (TPR) domain 14
MYND domain 13
BRCT domain 12
Clathrin propeller repeat 12
Galactose oxidase, central domain 12
Gamma adaptin ear (GAE) domain 12
GYF domain 11
TKB Domain 11
Alpha M I domain 10
BIR domain 10
FHA domain 10
Alpha-ear domain 9
Beta-trefoil domain 9
TRAF-like domain 9
Dynein light chain type 1 8
Elastin-binding domain of EBP 8
RRM domain 8
V-domain 8
Chromo shadow domain 7
EBH domain 7
PAH2 domain 7
CaMK domain 6
EABR domain 6
N-terminal Integrin beta subunit 6
Catalytic domain of Ptprz 5
TFAT domain 5
HEAT repeat domain 5
MSP domain 5
SPRY domain 5
TRFH domain 5
VHL beta domain 5
WRKY domain 5
CB3 region 4
E1 domain 4
ND1 domain 4
ASH-RhoGAP-like domain 3
B-box portion of the Rb pocket domain 3
CAP-Gly domain 3
Sufu N-terminal binding domain 3
Leucine-rich repeats (LRR) 3
NOT1 superfamily homology domain 3
PUB domain 3
Rb pocket AB groove 3
UHM domain 3
Carboxyl-flanking region of the SPXX region 2
Catalytic domain of PKC-zeta 2
DGR domain 2
FERM domain 2
FG-GAP repeat 2
HORMA domain 2
RNP domain 2
Activator-binding Domain 1
ATP-binding pocket 1
Bcl-XL Delta-loop 1
C1 domain 1
Fibronectin-binding motif 1
Fn14 fragment of Fn 1
LysM domain 1
Plus3 domain 1
GTPase binding domain 1
 
LINKS

The Universal Protein Resource (UniProt)

 

RCSB Protein Data Bank (PDB)

 

PubMed

 
TEAM
  • Debasree Sarkar
    Senior Research Fellow
    Bose Institute, Kolkata
    debasree@jcbose.ac.in
  • Tanmoy Jana
    Senior Research Fellow
    Bose Institute, Kolkata
    tjana@jcbose.ac.in
  • Dr. Sudipto Saha
    Scientist
    Bose Institute, Kolkata
    ssaha4@jcbose.ac.in
  •  

    © 2014 Bose Institute, Kolkata. All rights reserved

    For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)