Query '14-3-3 domain' matched 100 Records
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Record No : 1 |
| Instance ID | 10001 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20001 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 2 |
| Instance ID | 10002 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20002 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 3 |
| Instance ID | 10003 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20003 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 4 |
| Instance ID | 10004 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20004 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 5 |
| Instance ID | 10005 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20005 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein zeta |
Record No : 6 |
| Instance ID | 10006 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20006 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein eta |
Record No : 7 |
| Instance ID | 10007 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20007 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein beta |
Record No : 8 |
| Instance ID | 10008 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20008 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein tau |
Record No : 9 |
| Instance ID | 10009 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSRSAP | | Bait Uniprot Accession | O35147 | | Bait Uniprot Identifier | BAD_RAT | | Bait Gene Name | Bad | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 134-139 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20009 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9369453 | | Comments | 14-3-3 binding motif in rat Bcl-xL/Bcl-2-associated death promoter that binds 14-3-3 protein zeta |
Record No : 10 |
| Instance ID | 10010 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSISLP | | Bait Uniprot Accession | Q99683 | | Bait Uniprot Identifier | M3K5_HUMAN | | Bait Gene Name | MAP3K5 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 963-968 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20010 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10411906 | | Comments | 14-3-3 binding motif in human ASK1 (or MAP3K5) that binds 14-3-3 protein zeta |
Record No : 11 |
| Instance ID | 10011 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSHSYP | | Bait Uniprot Accession | P03076 | | Bait Uniprot Identifier | MT_POVM3 | | Bait Gene Name | Not Available | | Bait Organism | Murine polyomavirus (strain 3) (MPyV) | | Sequence Position | 254-259 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; SPR | | Interaction ID | 20011 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9428519 | | Comments | 14-3-3 binding motif in Murine polyomavirus Middle T antigen that binds 14-3-3 protein zeta |
Record No : 12 |
| Instance ID | 10012 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSCTWP | | Bait Uniprot Accession | P98177 | | Bait Uniprot Identifier | FOXO4_HUMAN | | Bait Gene Name | FOXO4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 29-34 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Molecular sieving; Cosedimentation; Mutation analysis | | Interaction ID | 20012 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14690436 | | Comments | 14-3-3 binding motif in Forkhead box protein O4 that binds 14-3-3 protein zeta |
Record No : 13 |
| Instance ID | 10013 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSHSSP | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 86-91 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 20013 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11118213 | | Comments | 14-3-3 binding motif in WW domain-containing transcription regulator protein 1 that binds 14-3-3 protein zeta |
Record No : 14 |
| Instance ID | 10014 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20014 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein epsilon |
Record No : 15 |
| Instance ID | 10015 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20015 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein gamma |
Record No : 16 |
| Instance ID | 10016 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20016 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein theta |
Record No : 17 |
| Instance ID | 10017 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20017 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein beta |
Record No : 18 |
| Instance ID | 10018 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20018 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein zeta |
Record No : 19 |
| Instance ID | 10019 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20019 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein eta |
Record No : 20 |
| Instance ID | 10020 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20020 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein zeta |
Record No : 21 |
| Instance ID | 10021 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20021 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein eta |
Record No : 22 |
| Instance ID | 10022 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20022 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein beta |
Record No : 23 |
| Instance ID | 10023 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20023 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein tau |
Record No : 24 |
| Instance ID | 10024 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RAHSSP | | Bait Uniprot Accession | P46937 | | Bait Uniprot Identifier | YAP1_HUMAN | | Bait Gene Name | YAP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 124-129 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 20024 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12535517, 17974916 | | Comments | Akt phosphorylates the Yes-associated protein, at serine 127, to induce interaction with 14-3-3 protein tau and attenuation of p73-mediated apoptosis |
Record No : 25 |
| Instance ID | 10025 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RHSSYP | | Bait Uniprot Accession | Q61337 | | Bait Uniprot Identifier | BAD_MOUSE | | Bait Gene Name | Bad | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 109-114 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20025 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8929531 | | Comments | Phosphorylation of death agonist BAD at Ser-112 in response to survival factor results in binding to 14-3-3 protein tau |
Record No : 26 |
| Instance ID | 10026 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSRSAP | | Bait Uniprot Accession | Q61337 | | Bait Uniprot Identifier | BAD_MOUSE | | Bait Gene Name | Bad | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 133-138 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20026 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10949026, 8929531 | | Comments | Phosphorylation of the proapoptotic Bcl-2 family member BAD at Ser-136 recruits 14-3-3 protein zeta that then function to increase the accessibility of Ser-155 to survival-promoting kinases |
Record No : 27 |
| Instance ID | 10027 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTESSP | | Bait Uniprot Accession | P08965 | | Bait Uniprot Identifier | MEI2_SCHPO | | Bait Gene Name | mei2 | | Bait Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | | Sequence Position | 435-440 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Competition binding; Mutation analysis | | Interaction ID | 20027 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11818066 | | Comments | Rad24p, a 14-3-3 protein, functions as a negative factor for meiosis by antagonizing the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p at Ser438 |
Record No : 28 |
| Instance ID | 10028 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRCRSLP | | Bait Uniprot Accession | Q63572 | | Bait Uniprot Identifier | TESK1_RAT | | Bait Gene Name | Tesk1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 435-441 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20028 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11555644 | | Comments | 14-3-3 beta interacts with Tesk1 through the C-terminal region of Tesk1 and in a manner dependent on the phosphorylation of Ser-439 within an RXXSXP motif |
Record No : 29 |
| Instance ID | 10029 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRAASMD | | Bait Uniprot Accession | P98177 | | Bait Uniprot Identifier | FOXO4_HUMAN | | Bait Gene Name | FOXO4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 193-199 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20029 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16114898 | | Comments | 14-3-3 protein zeta interaction with nuclear localization sequence of human forkhead transcription factor FoxO4 could inhibit interaction between FoxO4 and nuclear importing machinery and thus shift the equilibrium of FoxO4 localization toward the cytoplasm |
Record No : 30 |
| Instance ID | 10030 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRSLSVE | | Bait Uniprot Accession | A2ALK8 | | Bait Uniprot Identifier | PTN3_MOUSE | | Bait Gene Name | Ptpn3 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 355-361 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20030 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9341175 | | Comments | Phosphorylation-dependent association between Tyrosine-protein phosphatase non-receptor type 3 (Ptpn3) and 14-3-3 protein beta mediated by Ser-359 of Ptpn3 |
Record No : 31 |
| Instance ID | 10031 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RLRRSLP | | Bait Uniprot Accession | Q14432 | | Bait Uniprot Identifier | PDE3A_HUMAN | | Bait Gene Name | PDE3A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 424-430 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20031 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16153182 | | Comments | PDE3A (phosphodiesterase 3A) binds directly to BMH1 (the 14-3-3 isoform from Saccharomyces cerevisiae) in a phosphorylation-dependent manner upon phosphorylation of Ser428 |
Record No : 32 |
| Instance ID | 10032 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RLRRSLP | | Bait Uniprot Accession | Q14432 | | Bait Uniprot Identifier | PDE3A_HUMAN | | Bait Gene Name | PDE3A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 424-430 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20032 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16153182 | | Comments | PDE3A (phosphodiesterase 3A) binds directly to BMH2 (the 14-3-3 isoform from Saccharomyces cerevisiae) in a phosphorylation-dependent manner upon phosphorylation of Ser428 |
Record No : 33 |
| Instance ID | 10033 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RSAGSIP | | Bait Uniprot Accession | Q04206 | | Bait Uniprot Identifier | TF65_HUMAN | | Bait Gene Name | RELA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 41-47 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20033 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16931600 | | Comments | 14-3-3 binding site in human Transcription factor NF-kappa-B p65 subunit (or RELA) that binds to 14-3-3 protein eta in response to TNFalpha stimulation, which indicates that 14-3-3 proteins facilitate the nuclear export of IkappaBalpha-p65 complexes and are required for the appropriate regulation of NFkappaB signaling |
Record No : 34 |
| Instance ID | 10034 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20034 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein epsilon, which may modulate their calcium extrusion activity |
Record No : 35 |
| Instance ID | 10035 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20035 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein zeta, which may modulate their calcium extrusion activity |
Record No : 36 |
| Instance ID | 10036 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20036 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein beta, which may modulate their calcium extrusion activity |
Record No : 37 |
| Instance ID | 10037 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20037 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein theta, which may modulate their calcium extrusion activity |
Record No : 38 |
| Instance ID | 10038 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRSLTVG | | Bait Uniprot Accession | P08965 | | Bait Uniprot Identifier | MEI2_SCHPO | | Bait Gene Name | mei2 | | Bait Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | | Sequence Position | 523-529 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Competition binding; Mutation analysis | | Interaction ID | 20038 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11818066 | | Comments | Rad24p, a 14-3-3 protein, functions as a negative factor for meiosis by antagonizing the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p at Thr527 |
Record No : 39 |
| Instance ID | 10039 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSHE | | Bait Uniprot Accession | Q61097 | | Bait Uniprot Identifier | KSR1_MOUSE | | Bait Gene Name | Ksr1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 294-299 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20039 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9858547 | | Comments | 14-3-3 binding motif (pS-297) in mouse Kinase suppressor of Ras 1 protein (Ksr1) that binds to 14-3-3 protein zeta |
Record No : 40 |
| Instance ID | 10040 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RTESVP | | Bait Uniprot Accession | Q61097 | | Bait Uniprot Identifier | KSR1_MOUSE | | Bait Gene Name | Ksr1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 389-394 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20040 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9858547 | | Comments | 14-3-3 binding motif (pS-392) in mouse Kinase suppressor of Ras 1 protein (Ksr1) that binds to 14-3-3 protein zeta |
Record No : 41 |
| Instance ID | 10041 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSAI | | Bait Uniprot Accession | Q8IPH9 | | Bait Uniprot Identifier | SLOB_DROME | | Bait Gene Name | Slob | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 51-56 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20041 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10230800 | | Comments | 14-3-3 binding motif (pS-54) in Drosophila Slowpoke-binding protein (Slob) that binds to 14-3-3 protein zeta |
Record No : 42 |
| Instance ID | 10042 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSASSE | | Bait Uniprot Accession | Q8IPH9 | | Bait Uniprot Identifier | SLOB_DROME | | Bait Gene Name | Slob | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 76-81 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20042 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10230800 | | Comments | 14-3-3 binding motif (pS-79) in Drosophila Slowpoke-binding protein (Slob) that binds to 14-3-3 protein zeta |
Record No : 43 |
| Instance ID | 10043 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSRSIP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 371-376 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20043 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-374) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 44 |
| Instance ID | 10044 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSRSIP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 371-376 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20044 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-374) in human Insulin receptor substrate 1 that binds to 14-3-3 protein zeta, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 45 |
| Instance ID | 10045 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KSVSAP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 638-643 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20045 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-641) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 46 |
| Instance ID | 10046 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KSVSAP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 638-643 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20046 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-641) in human Insulin receptor substrate 1 that binds to 14-3-3 protein zeta, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 47 |
| Instance ID | 10047 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSQS | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 267-272 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20047 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-270) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 48 |
| Instance ID | 10048 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSQS | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 267-272 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20048 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-270) in human Insulin receptor substrate 1 that binds to 14-3-3 protein zeta, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 49 |
| Instance ID | 10049 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RAQSSP | | Bait Uniprot Accession | P56524 | | Bait Uniprot Identifier | HDAC4_HUMAN | | Bait Gene Name | HDAC4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 629-634 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20049 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10869435 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-632) in human Histone deacetylase 4 that mediates interaction with 14-3-3 protein epsilon and results in the sequestration of HDAC4 in the cytoplasm, wheras loss of this interaction allows HDAC4 to translocate to the nucleus, interact with HDAC3, and repress gene expression |
Record No : 50 |
| Instance ID | 10050 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RAQSSP | | Bait Uniprot Accession | P56524 | | Bait Uniprot Identifier | HDAC4_HUMAN | | Bait Gene Name | HDAC4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 629-634 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20050 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10869435 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-632) in human Histone deacetylase 4 that mediates interaction with 14-3-3 protein beta and results in the sequestration of HDAC4 in the cytoplasm, wheras loss of this interaction allows HDAC4 to translocate to the nucleus, interact with HDAC3, and repress gene expression |
Record No : 51 |
| Instance ID | 10051 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSSTPP | | Bait Uniprot Accession | P43565 | | Bait Uniprot Identifier | RIM15_YEAST | | Bait Gene Name | RIM15 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 1072-1077 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20051 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16308562 | | Comments | Phosphorylation-dependent 14-3-3-binding site in yeast PAS kinase RIM15 (which functions as a key controller of many aspects of the quiescent G0 state) that mediates binding to BMH2 (the 14-3-3 isoform from Saccharomyces cerevisiae) thereby effectively sequestering Rim15 in the cytoplasm (dephosphorylation of the 14-3-3-binding site in Rim15, in turn, enabling nuclear import of Rim15) |
Record No : 52 |
| Instance ID | 10052 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSLSVE | | Bait Uniprot Accession | P26045 | | Bait Uniprot Identifier | PTN3_HUMAN | | Bait Gene Name | PTPN3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 356-361 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20052 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9341175 | | Comments | Phosphorylation-dependent association between human Protein-tyrosine phosphatase H1 (or PTPN3) and 14-3-3 protein beta mediated by pSer-359 of PTPH1 |
Record No : 53 |
| Instance ID | 10053 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RVDSEP | | Bait Uniprot Accession | P26045 | | Bait Uniprot Identifier | PTN3_HUMAN | | Bait Gene Name | PTPN3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20053 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9341175 | | Comments | Phosphorylation-dependent association between human Protein-tyrosine phosphatase H1 (or PTPN3) and 14-3-3 protein beta mediated by pSer-835 of PTPH1 |
Record No : 54 |
| Instance ID | 10054 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSCTWP | | Bait Uniprot Accession | O43524 | | Bait Uniprot Identifier | FOXO3_HUMAN | | Bait Gene Name | FOXO3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 29-34 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20054 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11864996 | | Comments | 14-3-3 binding site (pT-32) in the human proapoptotic transcription factor FKHRL1 (or FOXO3) that mediates binding to 14-3-3 protein zeta |
Record No : 55 |
| Instance ID | 10055 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20055 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein beta |
Record No : 56 |
| Instance ID | 10056 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20056 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein gamma |
Record No : 57 |
| Instance ID | 10057 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20057 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein epsilon |
Record No : 58 |
| Instance ID | 10058 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20058 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein zeta |
Record No : 59 |
| Instance ID | 10059 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20059 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein eta |
Record No : 60 |
| Instance ID | 10060 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20060 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein tau |
Record No : 61 |
| Instance ID | 10061 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KSATTT | | Bait Uniprot Accession | P05107 | | Bait Uniprot Identifier | ITB2_HUMAN | | Bait Gene Name | ITGB2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 755-760 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; SPR; X-ray crystallography; Pull down | | Interaction ID | 20061 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18550856 | | Comments | Beta2 integrin phosphorylation on cytoplasmic Thr758 acts as a molecular switch to inhibit filamin binding and allow 14-3-3 protein zeta binding to the integrin cytoplasmic domain, thereby modulating T-cell adhesion |
Record No : 62 |
| Instance ID | 10062 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RAVSMD | | Bait Uniprot Accession | O43524 | | Bait Uniprot Identifier | FOXO3_HUMAN | | Bait Gene Name | FOXO3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 250-255 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20062 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11864996 | | Comments | 14-3-3 binding site (pS-253) in the human proapoptotic transcription factor FKHRL1 (or FOXO3) that mediates binding to 14-3-3 protein zeta |
Record No : 63 |
| Instance ID | 10063 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20063 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein beta |
Record No : 64 |
| Instance ID | 10064 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20064 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein gamma |
Record No : 65 |
| Instance ID | 10065 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20065 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein epsilon |
Record No : 66 |
| Instance ID | 10066 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20066 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein zeta |
Record No : 67 |
| Instance ID | 10067 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20067 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein eta |
Record No : 68 |
| Instance ID | 10068 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20068 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein tau |
Record No : 69 |
| Instance ID | 10069 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30305 | | Bait Uniprot Identifier | MPIP2_HUMAN | | Bait Gene Name | CDC25B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 320-325 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; GFP tag; Co-IP; Mutation analysis; Western blot | | Interaction ID | 20069 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801879 | | Comments | 14-3-3 binding site (pS-323) in the human Dual specificity phosphatase Cdc25B, a key regulator of entry into mitosis, that mediates binding to 14-3-3 protein beta [mitotic phosphorylation of Ser321 enhances the dephosphorylation of Ser(323) to block 14-3-3 binding to this site] |
Record No : 70 |
| Instance ID | 10070 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30305 | | Bait Uniprot Identifier | MPIP2_HUMAN | | Bait Gene Name | CDC25B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 320-325 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; GFP tag; Co-IP; Mutation analysis; Western blot | | Interaction ID | 20070 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801879 | | Comments | 14-3-3 binding site (pS-323) in the human Dual specificity phosphatase Cdc25B, a key regulator of entry into mitosis, that mediates binding to 14-3-3 protein epsilon [mitotic phosphorylation of Ser321 enhances the dephosphorylation of Ser(323) to block 14-3-3 binding to this site] |
Record No : 71 |
| Instance ID | 10071 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30307 | | Bait Uniprot Identifier | MPIP3_HUMAN | | Bait Gene Name | CDC25C | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 213-218 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20071 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9278512 | | Comments | 14-3-3 binding site (pS-216) in the human Dual specificity phosphatase Cdc25C that mediates binding to 14-3-3 protein beta |
Record No : 72 |
| Instance ID | 10072 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSRSCR | | Bait Uniprot Accession | P04233 | | Bait Uniprot Identifier | HG2A_HUMAN | | Bait Gene Name | CD74 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 5-10 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20072 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9448284 | | Comments | 14-3-3 binding site (pS-8) in the human HLA class II histocompatibility antigen gamma chain (CD74) that mediates binding to 14-3-3 protein eta |
Record No : 73 |
| Instance ID | 10073 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20073 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein epsilon |
Record No : 74 |
| Instance ID | 10074 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20074 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein gamma |
Record No : 75 |
| Instance ID | 10075 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20075 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein theta |
Record No : 76 |
| Instance ID | 10076 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20076 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein beta |
Record No : 77 |
| Instance ID | 10077 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20077 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein zeta |
Record No : 78 |
| Instance ID | 10078 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20078 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein eta |
Record No : 79 |
| Instance ID | 10079 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSAP | | Bait Uniprot Accession | Q02156 | | Bait Uniprot Identifier | KPCE_HUMAN | | Bait Gene Name | PRKCE | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 343-348 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Chromatography technologies; Peptide binding to perpetrator; ITC; X-ray crystallography | | Interaction ID | 20079 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19662078 | | Comments | Phosphoserine-containing motif (pS346) in human Protein kinase C epsilon type that bind to 14-3-3 protein zeta |
Record No : 80 |
| Instance ID | 10080 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KALSFD | | Bait Uniprot Accession | Q02156 | | Bait Uniprot Identifier | KPCE_HUMAN | | Bait Gene Name | PRKCE | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 365-370 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Chromatography technologies; Peptide binding to perpetrator; ITC; X-ray crystallography | | Interaction ID | 20080 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19662078 | | Comments | Phosphoserine-containing motif (pS368) in human Protein kinase C epsilon type that bind to 14-3-3 protein zeta |
Record No : 81 |
| Instance ID | 11466 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSSSAP | | Bait Uniprot Accession | P15056 | | Bait Uniprot Identifier | BRAF_HUMAN | | Bait Gene Name | BRAF | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 362-367 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21466 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312 | | Comments | 14-3-3 binding motif in BRAF (pS-365) which binds 14-3-3 protein zeta |
Record No : 82 |
| Instance ID | 11467 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSASEP | | Bait Uniprot Accession | P15056 | | Bait Uniprot Identifier | BRAF_HUMAN | | Bait Gene Name | BRAF | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 726-731 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21467 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312 | | Comments | 14-3-3 binding motif in BRAF (pS-729) which binds 14-3-3 protein zeta |
Record No : 83 |
| Instance ID | 11468 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30305 | | Bait Uniprot Identifier | MPIP2_HUMAN | | Bait Gene Name | CDC25B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 320-325 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21468 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312 | | Comments | 14-3-3 binding motif in CDC25B (pS-323) which binds 14-3-3 protein zeta |
Record No : 84 |
| Instance ID | 11469 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSKSAP | | Bait Uniprot Accession | Q02156 | | Bait Uniprot Identifier | KPCE_HUMAN | | Bait Gene Name | PRKCE | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 343-348 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Sequence based prediction | | Interaction ID | 21469 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 19662078 | | Comments | 14-3-3 binding motif in PRKCE (pS-346) which binds 14-3-3 protein zeta |
Record No : 85 |
| Instance ID | 11470 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSHSYP | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Bait Organism | Murine polyomavirus (strain A2) (MPyV) | | Sequence Position | 254-259 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Sequence based prediction | | Interaction ID | 21470 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 9428519 | | Comments | 14-3-3 binding motif in Polyoma middle T antigen (pS-257) which binds 14-3-3 protein zeta |
Record No : 86 |
| Instance ID | 11471 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | KCSTWP | | Bait Uniprot Accession | P16471 | | Bait Uniprot Identifier | PRLR_HUMAN | | Bait Gene Name | PRLR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 412-417 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21471 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12819209 | | Comments | Motif mediating interaction between PRLR and 14-3-3 protein zeta |
Record No : 87 |
| Instance ID | 11472 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | KCSTWP | | Bait Uniprot Accession | P16471 | | Bait Uniprot Identifier | PRLR_HUMAN | | Bait Gene Name | PRLR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 412-417 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21472 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12819209 | | Comments | Motif mediating interaction between PRLR and 14-3-3 protein gamma |
Record No : 88 |
| Instance ID | 11874 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Bait Organism | Pseudomonas aeruginosa | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21874 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10213629, 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein zeta |
Record No : 89 |
| Instance ID | 11875 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Bait Organism | Pseudomonas aeruginosa | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21875 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein beta |
Record No : 90 |
| Instance ID | 11876 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Bait Organism | Pseudomonas aeruginosa | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21876 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein epsilon |
Record No : 91 |
| Instance ID | 11877 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Bait Organism | Pseudomonas aeruginosa | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21877 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein gamma |
Record No : 92 |
| Instance ID | 11878 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Bait Organism | Pseudomonas aeruginosa | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21878 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein eta |
Record No : 93 |
| Instance ID | 11932 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSRSLP | | Bait Uniprot Accession | P32927 | | Bait Uniprot Identifier | IL3RB_HUMAN | | Bait Gene Name | CSF2RB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 598-603 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21932 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10477722 | | Comments | A phosphoserine motif in the cytoplasmic domain of Cytokine receptor common subunit beta that interacts with the adaptor protein 14-3-3 zeta |
Record No : 94 |
| Instance ID | 12001 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KAKSCTVM | | Bait Uniprot Accession | P61587 | | Bait Uniprot Identifier | RND3_HUMAN | | Bait Gene Name | RND3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 237-244 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; BLI | | Interaction ID | 22001 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 3 (RND3) that interacts with human 14-3-3 protein zeta on being phosphorylated at Ser-240 by ROCK1 |
Record No : 95 |
| Instance ID | 12002 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KAKSCTVM | | Bait Uniprot Accession | P61587 | | Bait Uniprot Identifier | RND3_HUMAN | | Bait Gene Name | RND3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 237-244 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down Assay; Co-IP; Pull down(GST tag) | | Interaction ID | 22002 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 3 (RND3) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-240 by ROCK1 |
Record No : 96 |
| Instance ID | 12003 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KAKSCSIM | | Bait Uniprot Accession | Q92730 | | Bait Uniprot Identifier | RND1_HUMAN | | Bait Gene Name | RND1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 225-232 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22003 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 1 (RND1) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-228 |
Record No : 97 |
| Instance ID | 12004 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | RAKSCNLM | | Bait Uniprot Accession | P52198 | | Bait Uniprot Identifier | RND2_HUMAN | | Bait Gene Name | RND2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 220-227 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22004 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 2 (RND2) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-223 |
Record No : 98 |
| Instance ID | 12005 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KKKSCLLL | | Bait Uniprot Accession | P62834 | | Bait Uniprot Identifier | RAP1A_HUMAN | | Bait Gene Name | RAP1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 177-184 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | BLI | | Interaction ID | 22005 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Ras-related protein RAP1A that interacts with human 14-3-3 protein zeta on being phosphorylated at Ser-180 |
Record No : 99 |
| Instance ID | 12039 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSNSCP | | Bait Uniprot Accession | Q6VV64 | | Bait Uniprot Identifier | KCNKI_MOUSE | | Bait Gene Name | Kcnk18 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 261-266 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 22039 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18397886 | | Comments | Mode I 14-3-3 binding motif in mouse Potassium channel TRESK (Kcnk18) that is required for the binding of human 14-3-3eta/YWHAH on phosphorylation of Ser-264 |
Record No : 100 |
| Instance ID | 12147 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RHYSDS | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Bait Organism | Human papillomavirus type 18 | | Sequence Position | 79-84 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 22147 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23175360 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS82) of E6 oncoprotein of Human papillomavirus type 18 that binds to 14-3-3 protein zeta |
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