Query   'B-box portion of the Rb pocket domain'  matched   3 Records

Record No : 1

Instance ID11797
Regular Expression[DE][LI]xCxE
Motif InstanceDLFCSE
Bait Uniprot AccessionQ2I7F9
Bait Uniprot IdentifierQ2I7F9_SV40
Bait Gene Namelarge T
Bait OrganismSimian virus 40 (SV40)
Sequence Position101-106
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; Competition binding assay
Interaction ID21797
Interacting DomainB-box portion of the Rb pocket domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)2138977, 2198278, 11226179
CommentsThe LxCxE motif of SV40 large T antigen that binds to the B-box portion of the pocket domain of the human retinoblastoma suppressor protein (pRb) and is required for inactivation of pRb that leads to tumorigenesis induced by SV40

Record No : 2

Instance ID11798
Regular Expression[DE][LI]xCxE
Motif InstanceDLTCHE
Bait Uniprot AccessionP03255
Bait Uniprot IdentifierE1A_ADE05
Bait Gene NameNot Available
Bait OrganismHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Sequence Position121-126
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Competition binding assay
Interaction ID21798
Interacting DomainB-box portion of the Rb pocket domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)2138977, 2198278
CommentsThe LxCxE motif of adenovirus E1A protein that binds to the human retinoblastoma suppressor protein (pRb) and is required for transformation

Record No : 3

Instance ID11799
Regular Expression[DE][LI]xCxE
Motif InstanceDLYCYE
Bait Uniprot AccessionP03129
Bait Uniprot IdentifierVE7_HPV16
Bait Gene NameE7
Bait OrganismHuman papillomavirus type 16
Sequence Position21-26
Critical ResiduesP1; P3; P4; P5; P6
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)X-ray crystallography; Mutational analysis; ITC; Competition binding assay
Interaction ID21799
Interacting DomainB-box portion of the Rb pocket domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)2198278, 9495340
CommentsThe LxCxE motif of the human papilloma virus type-16 E7 protein (HPV-16 E7) that binds a highly conserved groove on the B-box portion of the pocket domain of the human retinoblastoma suppressor protein (pRb) and is believed to be important in the process of cellular transformation that leads to cervical carcinoma


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)