Query 'Beta-trefoil domain' matched 9 Records
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Record No : 1 |
| Instance ID | 11206 | | Regular Expression | WxP | | Motif Instance | WHP | | Bait Uniprot Accession | F5H9D8 | | Bait Uniprot Identifier | F5H9D8_HHV8 | | Bait Gene Name | vIRF-4 | | Bait Organism | Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) | | Sequence Position | 471-473 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Hybridization of peptide arrays; Y2H; Competition binding assay | | Interaction ID | 21206 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Kaposi's sarcoma | | Inhibitor(s) | Unknown | | Reference(s) | 20861242 | | Comments | Short peptide motif in VIRF-4 protein of Human herpesvirus 8 through which it targets the hydrophobic pocket in the beta trefoil domain of CSL/CBF1 (RBPJ) |
Record No : 2 |
| Instance ID | 11207 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1758-1760 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; MASLS; Cross-linking experiments; Comigration in gel electrophoresis | | Interaction ID | 21207 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17070841, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region (the approximately 140 residue polypeptide segment N-terminal to the ANK domain) of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of human CSL (RBPJ) |
Record No : 3 |
| Instance ID | 11208 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1758-1760 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21208 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8749394, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 4 |
| Instance ID | 11209 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q61982 | | Bait Uniprot Identifier | NOTC3_MOUSE | | Bait Gene Name | Notch3 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1676-1678 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; ITC | | Interaction ID | 21209 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8898100, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch3 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 5 |
| Instance ID | 11210 | | Regular Expression | WxP | | Motif Instance | WLP | | Bait Uniprot Accession | O35516 | | Bait Uniprot Identifier | NOTC2_MOUSE | | Bait Gene Name | Notch2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1706-1708 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; ITC | | Interaction ID | 21210 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8898100, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch2 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 6 |
| Instance ID | 11211 | | Regular Expression | WxP | | Motif Instance | WLP | | Bait Uniprot Accession | P31695 | | Bait Uniprot Identifier | NOTC4_MOUSE | | Bait Gene Name | Notch4 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1478-1480 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; ITC | | Interaction ID | 21211 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8898100, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch4 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 7 |
| Instance ID | 11212 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | P07207 | | Bait Uniprot Identifier | NOTCH_DROME | | Bait Gene Name | N | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 1776-1778 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21212 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8749394 | | Comments | The conserved WFP sequence motif in the Drosophila Notch (designated dNotch) protein that mediates binding to the beta trefoil domain (or BTD) of Drosophila Suppressor of hairless protein (Su(H) or dRBP-JK) |
Record No : 8 |
| Instance ID | 11213 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1758-1760 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21213 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8749394 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of Drosophila Suppressor of hairless protein (Su(H) or dRBP-JK) |
Record No : 9 |
| Instance ID | 11214 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | P07207 | | Bait Uniprot Identifier | NOTCH_DROME | | Bait Gene Name | N | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 1776-1778 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21214 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8749394 | | Comments | The conserved WFP sequence motif in the Drosophila Notch (designated dNotch) protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
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