Query 'CAP-Gly domain' matched 3 Records
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Record No : 1 |
| Instance ID | 10226 | | Regular Expression | [ED]x{0,2}[ED]x{0,2}[EDQ]x{0,1}[YF]$ | | Motif Instance | EEQEEY | | Bait Uniprot Accession | Q15691 | | Bait Uniprot Identifier | MARE1_HUMAN | | Bait Gene Name | MAPRE1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 263-268 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Co-IP; Pull down; Mutation analysis; X-ray crystallography; ITC | | Interaction ID | 20226 | | Interacting Domain | CAP-Gly domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16949363, 16148041, 16109370, 16949363 | | Comments | The flexible tail from the carboxy-terminal dimerization domain of human EB1 (MAPRE1) that negatively regulates EB1 activity and binds to the microtubule binding (CAP-Gly) domain of the dynactin subunit p150Glued, an allosteric activator that relieves its auto-inhibited conformation |
Record No : 2 |
| Instance ID | 10227 | | Regular Expression | [ED]x{0,2}[ED]x{0,2}[EDQ]x{0,1}[YF]$ | | Motif Instance | EGEEEGEEY | | Bait Uniprot Accession | Q71U36 | | Bait Uniprot Identifier | TBA1A_HUMAN | | Bait Gene Name | TUBA1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 443-451 | | Critical Residues | P4; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; NMR; Mutation analysis; SPR | | Interaction ID | 20227 | | Interacting Domain | CAP-Gly domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16954346, 17563362 | | Comments | The C-Terminal acidic tail of Tubulin alpha-1A chain that is responsible for CLIP-170 binding, thus providing a structural basis for the proposed CLIP-170 copolymerization with tubulin on the microtubule plus end |
Record No : 3 |
| Instance ID | 10228 | | Regular Expression | xW[RK][DE]GCY$ | | Motif Instance | SWKDGCY | | Bait Uniprot Accession | Q9P270 | | Bait Uniprot Identifier | SLAI2_HUMAN | | Bait Gene Name | SLAIN2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 575-581 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; ITC; X-ray crystallography | | Interaction ID | 20228 | | Interacting Domain | CAP-Gly domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21646404 | | Comments | The C-Terminal acidic tail of SLAIN2 that is important for the interaction with CLIP-170 in cells |
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