Query   'Chromo shadow domain'  matched   7 Records

Record No : 1

Instance ID10467
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePLVVL
Bait Uniprot AccessionQ9VI63
Bait Uniprot IdentifierQ9VI63_DROME
Bait Gene NameAlh
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position1051-1055
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down(GST tag)
Interaction ID20467
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11266362
CommentsThe PxVxL HP1-binding motif found in the Drosophila homolog of the human AF10, dAF10, that interacts with a chomoshadow domain dimer of the heterochromatin protein 1 (HP1)

Record No : 2

Instance ID10468
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePVVVL
Bait Uniprot AccessionQ9QWF0
Bait Uniprot IdentifierCAF1A_MOUSE
Bait Gene NameChaf1a
Bait OrganismMus musculus (Mouse)
Sequence Position222-226
Critical ResiduesP1; P3; P5
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)NMR
Interaction ID20468
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14765118
CommentsThe chromo shadow domain from mouse HP1 beta (Cbx1) bound to a peptide containing a consensus PXVXL motif found in mouse Chaf1a (CAF‐1)

Record No : 3

Instance ID10469
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePLVLL
Bait Uniprot AccessionP12956
Bait Uniprot IdentifierXRCC6_HUMAN
Bait Gene NameXRCC6
Bait OrganismHomo sapiens (Human)
Sequence Position352-356
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Co-IP; Pull down(GST tag)
Interaction ID20469
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11112778
CommentsHuman Ku70 (DNA repair protein XRCC6) interacts with heterochromatin protein 1alpha (HP1 alpha/CBX5) using a HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains in HP1

Record No : 4

Instance ID10470
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePMVAL
Bait Uniprot AccessionO00268
Bait Uniprot IdentifierTAF4_HUMAN
Bait Gene NameTAF4
Bait OrganismHomo sapiens (Human)
Sequence Position764-768
Critical ResiduesP3; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20470
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11959914
CommentsHuman Transcription initiation factor TFIID subunit 4/TAF(II)130 possesses a pentapeptide HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains of HP1 gamma

Record No : 5

Instance ID10471
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePVVMM
Bait Uniprot AccessionP20193
Bait Uniprot IdentifierSUV37_DROME
Bait Gene NameSu(var)3-7
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position394-398
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Classical fluorescence spectroscopy
Interaction ID20471
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12163401
CommentsThe PxVxL HP1-binding motif found in the Drosophila protein Suppressor of variegation 3-7 [Su(var)3-7] that interacts with a chomoshadow domain dimer of the heterochromatin protein 1 (HP1)

Record No : 6

Instance ID10472
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePRVSL
Bait Uniprot AccessionQ13263
Bait Uniprot IdentifierTIF1B_HUMAN
Bait Gene NameTRIM28
Bait OrganismHomo sapiens (Human)
Sequence Position486-490
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPR; GFP tag; Competition binding; Co-IP; Western blot; Mutation analysis
Interaction ID20472
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10938122, 16637071, 10938122
CommentsHuman Nuclear corepressor KAP-1 (E3 SUMO-protein ligase TRIM28) interacts with heterochromatin protein 1alpha (HP1 alpha/CBX5) using a HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains in HP1

Record No : 7

Instance ID10473
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePRVSL
Bait Uniprot AccessionQ62318
Bait Uniprot IdentifierTIF1B_MOUSE
Bait Gene NameTrim28
Bait OrganismMus musculus (Mouse)
Sequence Position486-490
Critical ResiduesP3; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Fluorescence technology; Co-IP; Alanine scanning
Interaction ID20473
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12154074
CommentsThe PxVxL HP1-binding motif found in the murine transcriptional intermediary factor 1 (TIF1) family protein TIF1beta that interacts with an interface formed by dimerization of two chromoshadow domains of HP1 alpha


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)