Query 'Cyclin, N-terminal domain' matched 18 Records
|
Record No : 1 |
| Instance ID | 10285 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | KKLRF | | Bait Uniprot Accession | P06400 | | Bait Uniprot Identifier | RB_HUMAN | | Bait Gene Name | RB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 873-877 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis | | Interaction ID | 20285 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 9891042 | | Comments | The cyclin recognition site (RxL motif) found in human Retinoblastoma-associated protein that interacts with Cyclin-A2 and thereby increases the specificity of phosphorylation by cyclin/CDK complexes |
Record No : 2 |
| Instance ID | 10286 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RNLL | | Bait Uniprot Accession | Q99640 | | Bait Uniprot Identifier | PMYT1_HUMAN | | Bait Gene Name | PKMYT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 486-489 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20286 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10373560 | | Comments | The cyclin recognition site (RxL motif) found in human Myt1 kinase that interacts with cyclin B1 and thereby induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes |
Record No : 3 |
| Instance ID | 10287 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLDL | | Bait Uniprot Accession | Q01094 | | Bait Uniprot Identifier | E2F1_HUMAN | | Bait Gene Name | E2F1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 90-94 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; Pull down | | Interaction ID | 20287 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 9199321 | | Comments | The human transcription factor E2F-1 interacts stably with cyclin A via a cyclin recognition site (RxL motif) thus being negatively regulated by the cyclin A-dependent kinases |
Record No : 4 |
| Instance ID | 10288 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLF | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 19-22 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20288 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11438644 | | Comments | The cyclin recognition site (RxL motif) found in human cyclin-dependent kinase inhibitor p21Cip1/Waf1 (CDKN1A) required for p21 interaction with cyclin E/Cdk2 |
Record No : 5 |
| Instance ID | 10290 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RTLF | | Bait Uniprot Accession | P50445 | | Bait Uniprot Identifier | RUX_DROME | | Bait Gene Name | rux | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 248-251 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20290 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11027291 | | Comments | Drosophila Roughex (Rux) protein acts as a distinct and specialized cell cycle inhibitor for cyclin A-dependent kinase activity through a physical association with cyclin A via its RxL motif |
Record No : 6 |
| Instance ID | 10291 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | KKLF | | Bait Uniprot Accession | Q9WTQ5 | | Bait Uniprot Identifier | AKA12_MOUSE | | Bait Gene Name | Akap12 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 501-504 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20291 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10982843 | | Comments | SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D through a physical association with cyclin D via its RxL motif |
Record No : 7 |
| Instance ID | 10292 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLVF | | Bait Uniprot Accession | Q99741 | | Bait Uniprot Identifier | CDC6_HUMAN | | Bait Gene Name | CDC6 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 94-98 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Pull down | | Interaction ID | 20292 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707497, 9889196 | | Comments | Cyclin A/CDK2 binds hCDC6 via the RxL motif in the N‐terminus of hCDC6 |
Record No : 8 |
| Instance ID | 10293 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RNLF | | Bait Uniprot Accession | P46527 | | Bait Uniprot Identifier | CDN1B_HUMAN | | Bait Gene Name | CDKN1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 30-33 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis | | Interaction ID | 20293 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 8684460, 9488039 | | Comments | The cyclin recognition site (RxL motif) found in human cyclin-dependent kinase inhibitor p27Kip1 (CDKN1B) required for p21 interaction with cyclin E/Cdk2 |
Record No : 9 |
| Instance ID | 10294 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RKLAF | | Bait Uniprot Accession | P38826 | | Bait Uniprot Identifier | ORC6_YEAST | | Bait Gene Name | ORC6 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 178-182 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20294 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15105375 | | Comments | Interaction of the S-phase cyclin Clb5 with the RxL motif in the yeast initiator protein Orc6 provides an origin-localized replication control switch |
Record No : 10 |
| Instance ID | 10295 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | KKLMF | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 381-385 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Mutation analysis; ITC; X-ray crystallography; Overlapping binding peptide | | Interaction ID | 20295 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10884347, 12501191 | | Comments | The C-terminal regulatory domain of human cellular tumor antigen p53 contains a functional docking site for cyclin A that is shared between the tumour suppressor proteins pRb and p53 |
Record No : 11 |
| Instance ID | 10296 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLF | | Bait Uniprot Accession | P28749 | | Bait Uniprot Identifier | RBL1_HUMAN | | Bait Gene Name | RBL1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 658-661 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis | | Interaction ID | 20296 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 11884610 | | Comments | The cyclin recognition site found in human Retinoblastoma-like protein 1 (p107) through which it physically associates with cyclin A |
Record No : 12 |
| Instance ID | 10297 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RKLEL | | Bait Uniprot Accession | P54198 | | Bait Uniprot Identifier | HIRA_HUMAN | | Bait Gene Name | HIRA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 629-633 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20297 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11238922 | | Comments | The RXL motif of HIRA, the human homologue of yeast Hir1p and Hir2p, that directs binding to cyclin A |
Record No : 13 |
| Instance ID | 10298 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RSLKL | | Bait Uniprot Accession | Q13352 | | Bait Uniprot Identifier | CENPR_HUMAN | | Bait Gene Name | ITGB3BP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 5-9 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20298 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10673397 | | Comments | The cyclin-binding RxL motif in human Beta-3-endonexin or Centromere protein R (Centromere protein R) through which it specifically binds cyclin A |
Record No : 14 |
| Instance ID | 10299 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLLF | | Bait Uniprot Accession | P30304 | | Bait Uniprot Identifier | MPIP1_HUMAN | | Bait Gene Name | CDC25A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 11-15 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20299 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9234691 | | Comments | The cyclin-binding RxL motif near the N terminus of human Cdc25A that mediates the association of Cdc25A with cyclin E and selectively interferes with the dephosphorylation of cyclin E-cdk2 |
Record No : 15 |
| Instance ID | 10300 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLF | | Bait Uniprot Accession | P06789 | | Bait Uniprot Identifier | VE1_HPV18 | | Bait Gene Name | E1 | | Bait Organism | Human papillomavirus type 18 | | Sequence Position | 127-130 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Mutation analysis | | Interaction ID | 20300 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9892642 | | Comments | The cyclin interaction motif (RXL motif) in the human papillomavirus (HPV) DNA replication initiation protein E1 that mediates its interaction with Cyclin E for phosphorylation by Cyclin E/Cdk2 Complex |
Record No : 16 |
| Instance ID | 10301 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RVLCF | | Bait Uniprot Accession | Q14207 | | Bait Uniprot Identifier | NPAT_HUMAN | | Bait Gene Name | NPAT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1062-1066 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Colocalization | | Interaction ID | 20301 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10995387 | | Comments | The cyclin-binding RxL motif through which p220/NPAT links cyclical cyclin E/Cdk2 kinase activity to replication-dependent histone gene transcription |
Record No : 17 |
| Instance ID | 10302 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RELFI | | Bait Uniprot Accession | P39880 | | Bait Uniprot Identifier | CUX1_HUMAN | | Bait Gene Name | CUX1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1301-1305 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20302 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11584018 | | Comments | The cyclin-binding RxL motif in human Homeobox protein cux-1 or CCAAT displacement protein (CDP) that is required for its interaction with Cyclin A-Cdk Complex resulting in the phosphorylation of CDP/Cux by cyclin A-Cdk1, which contributes to down-modulate CDP/Cux activity as cells progress into the G(2) phase of the cell cycle |
Record No : 18 |
| Instance ID | 12153 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLL | | Bait Uniprot Accession | P06791 | | Bait Uniprot Identifier | VE4_HPV18 | | Bait Gene Name | E4 | | Bait Organism | Human papillomavirus type 18 | | Sequence Position | 43-46 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Competition binding | | Interaction ID | 22153 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23065011 | | Comments | The cyclin interaction motif (RXL motif) in the human papilloma virus E4 protein that directs binding to cyclin A |
|
