Query   'DGR domain'  matched   2 Records

Record No : 1

Instance ID11999
Regular ExpressionETGE
Motif InstanceETGE
Bait Uniprot AccessionQ60795
Bait Uniprot IdentifierNF2L2_MOUSE
Bait Gene NameNfe2l2
Bait OrganismMus musculus (Mouse)
Sequence Position79-82
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)Mutation analysis; Co-IP; X-ray crystallography; ITC
Interaction ID21999
Interacting DomainDGR domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16507366
CommentsThe ETGE motif within the N-terminal Neh2 domain of mouse Nrf2, a basic region-leucine zipper (bZIP) transcription factor, binds the DGR domain in the beta propeller of mouse Keap1, which is essential to suppress Nrf2 activity

Record No : 2

Instance ID12000
Regular ExpressionETGE
Motif InstanceENGE
Bait Uniprot AccessionP26350
Bait Uniprot IdentifierPTMA_MOUSE
Bait Gene NamePtma
Bait OrganismMus musculus (Mouse)
Sequence Position43-46
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)X-ray crystallography
Interaction ID22000
Interacting DomainDGR domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18391415
CommentsThe Mouse nuclear oncoprotein Prothymosin alpha (Ptma) interacts directly with the beta propeller of mouse Keap1 through its ENGE peptide sequence


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)