LMPID

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Query 'E1 domain' matched 4 Records

Record No : 1

Instance ID	11972
Regular Expression	NxI
Motif Instance	NAI
Bait Uniprot Accession	O94907
Bait Uniprot Identifier	DKK1_HUMAN
Bait Gene Name	DKK1
Bait Organism	Homo sapiens (Human)
Sequence Position	40-42
Critical Residues	P1; P3
Motif PTM(s)	Unknown
Secondary Structure	Unknown
Experimental Method(s)	X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA
Interaction ID	21972
Interacting Domain	E1 domain
Disease Association(s)	Cancer; Alzheimer's disease; Bone disease
Inhibitor(s)	Unknown
Reference(s)	21944579
Comments	The NxI peptide motif in the Wnt pathway inhibitor Dickkopf-1 (DKK1) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 thereby inhibiting LRP6 interaction with Wnt

Record No : 2

Instance ID	11973
Regular Expression	NxI
Motif Instance	NSI
Bait Uniprot Accession	Q9UBU2
Bait Uniprot Identifier	DKK2_HUMAN
Bait Gene Name	DKK2
Bait Organism	Homo sapiens (Human)
Sequence Position	36-38
Critical Residues	P1; P3
Motif PTM(s)	Unknown
Secondary Structure	Unknown
Experimental Method(s)	Sequence based prediction; BLI
Interaction ID	21973
Interacting Domain	E1 domain
Disease Association(s)	Cancer; Alzheimer's disease; Bone disease
Inhibitor(s)	Unknown
Reference(s)	21944579
Comments	The NxI peptide motif in the Wnt pathway inhibitor Dickkopf-2 (DKK2) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 thereby inhibiting LRP6 interaction with Wnt

Record No : 3

Instance ID	11974
Regular Expression	NxI
Motif Instance	NAI
Bait Uniprot Accession	Q9BQB4
Bait Uniprot Identifier	SOST_HUMAN
Bait Gene Name	SOST
Bait Organism	Homo sapiens (Human)
Sequence Position	117-119
Critical Residues	P1; P3
Motif PTM(s)	Unknown
Secondary Structure	Unknown
Experimental Method(s)	X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA
Interaction ID	21974
Interacting Domain	E1 domain
Disease Association(s)	Bone dysplasia
Inhibitor(s)	Unknown
Reference(s)	21944579
Comments	The NxI peptide motif in the Wnt pathway inhibitor Sclerostin (SOST) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 and for inhibitory function

Record No : 4

Instance ID	11975
Regular Expression	NxI
Motif Instance	NWI
Bait Uniprot Accession	Q6X4U4
Bait Uniprot Identifier	SOSD1_HUMAN
Bait Gene Name	SOSTDC1
Bait Organism	Homo sapiens (Human)
Sequence Position	112-114
Critical Residues	P1; P3
Motif PTM(s)	Unknown
Secondary Structure	Unknown
Experimental Method(s)	Sequence based prediction; ELISA
Interaction ID	21975
Interacting Domain	E1 domain
Disease Association(s)	Unknown
Inhibitor(s)	Unknown
Reference(s)	21944579, 12900447
Comments	The NxI peptide motif in the Wnt pathway inhibitor WISE (SOSTDC1) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)