Query 'Eukaryotic initiation factor 4E' matched 13 Records
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Record No : 1 |
| Instance ID | 10409 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YGPTFLL | | Bait Uniprot Accession | P39935 | | Bait Uniprot Identifier | IF4F1_YEAST | | Bait Gene Name | TIF4631 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 452-458 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20409 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9118949 | | Comments | YxxxxL motif in yeast Eukaryotic initiation factor 4F subunit p150 (eIF4G1) that mediate binding to the dorsal surface of eIF4E, a key regulator of eukaryotic cap-dependent translation, and play a role in translation initiation, via interactions with eIF4G |
Record No : 2 |
| Instance ID | 10410 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YGPTFLL | | Bait Uniprot Accession | P39936 | | Bait Uniprot Identifier | IF4F2_YEAST | | Bait Gene Name | TIF4632 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 423-429 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20410 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9118949 | | Comments | YxxxxL motif in yeast Eukaryotic initiation factor 4F subunit p130 (eIF4G2) that mediate binding to the dorsal surface of eIF4E, a key regulator of eukaryotic cap-dependent translation, and play a role in translation initiation, via interactions with eIF4G |
Record No : 3 |
| Instance ID | 10411 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDREQLL | | Bait Uniprot Accession | O61380 | | Bait Uniprot Identifier | O61380_DROME | | Bait Gene Name | eIF4G | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 621-627 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20411 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10872469 | | Comments | YxxxxL motif in Drosophila Translation initiation factor eIF4G that mediate binding to the dorsal surface of eIF4E, a key regulator of eukaryotic cap-dependent translation, and play a role in translation initiation, via interactions with eIF4G |
Record No : 4 |
| Instance ID | 10412 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YTIDELF | | Bait Uniprot Accession | P12962 | | Bait Uniprot Identifier | CAF20_YEAST | | Bait Gene Name | CAF20 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 4-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20412 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9118949 | | Comments | In the yeast Saccharomyces cerevisiae, Cap-associated protein CAF20 or p20 is a regulator of eIF4E activity which represses cap-dependent initiation of translation by interfering with the interaction of eIF4E with eIF4G |
Record No : 5 |
| Instance ID | 10413 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDRKFLL | | Bait Uniprot Accession | O60516 | | Bait Uniprot Identifier | 4EBP3_HUMAN | | Bait Gene Name | EIF4EBP3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 40-46 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20413 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10394359, 9593750 | | Comments | The eIF4E binding motif found in human 4E-BP3, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation |
Record No : 6 |
| Instance ID | 10414 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDRKFLL | | Bait Uniprot Accession | Q13542 | | Bait Uniprot Identifier | 4EBP2_HUMAN | | Bait Gene Name | EIF4EBP2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 54-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; SPR | | Interaction ID | 20414 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10406811 | | Comments | The eIF4E binding motif found in human 4E-BP2, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation |
Record No : 7 |
| Instance ID | 10415 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDRKFLM | | Bait Uniprot Accession | Q13541 | | Bait Uniprot Identifier | 4EBP1_HUMAN | | Bait Gene Name | EIF4EBP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 54-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis; Colocalization; Y2H | | Interaction ID | 20415 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10394359, 10406811 | | Comments | The eIF4E binding motif found in human 4E-BP1, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation |
Record No : 8 |
| Instance ID | 10416 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YEAVELL | | Bait Uniprot Accession | Q8TEQ6 | | Bait Uniprot Identifier | GEMI5_HUMAN | | Bait Gene Name | GEMIN5 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 992-998 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Quantitative mass spectrometry; Colocalization; Y2H | | Interaction ID | 20416 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16739988 | | Comments | The eIF4E binding motif found in human Gem-associated protein 5 (Gemin5), a scaffolding protein involved in ribonucleoprotein assembly, that may mediate the interaction between eIF4E and Gemin5 |
Record No : 9 |
| Instance ID | 10417 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YTRSRLM | | Bait Uniprot Accession | Q9VMA3 | | Bait Uniprot Identifier | CUP_DROME | | Bait Gene Name | cup | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 327-333 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20417 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14685270 | | Comments | The eIF4E binding motif in Drosophila Cup protein that mediates its interaction with eIF4E, which blocks the binding of eIF4G to eIF4E and mediates an indirect interaction between Smaug and eIF4E, resulting in translational repression |
Record No : 10 |
| Instance ID | 10418 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDREFLL | | Bait Uniprot Accession | Q04637 | | Bait Uniprot Identifier | IF4G1_HUMAN | | Bait Gene Name | EIF4G1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 612-618 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Far Western blotting | | Interaction ID | 20418 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7651417 | | Comments | The eIF4E binding motif found in human Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) or p220 that is critical for the interaction with EIF4E |
Record No : 11 |
| Instance ID | 10419 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDREFLL | | Bait Uniprot Accession | O43432 | | Bait Uniprot Identifier | IF4G3_HUMAN | | Bait Gene Name | EIF4G3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 624-630 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20419 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10394359 | | Comments | The eIF4E binding motif found in human Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) that is critical for the interaction with EIF4E |
Record No : 12 |
| Instance ID | 10420 | | Regular Expression | YxPPx[ILMV]R | | Motif Instance | YIPPHLR | | Bait Uniprot Accession | O00571 | | Bait Uniprot Identifier | DDX3X_HUMAN | | Bait Gene Name | DDX3X | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 38-44 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20420 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17667941 | | Comments | Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by directly interacting with the dorsal surface of eIF4E through the conserved eIF4E-binding motif |
Record No : 13 |
| Instance ID | 12184 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YGRDFLL | | Bait Uniprot Accession | Q9UNK9 | | Bait Uniprot Identifier | ANGE1_HUMAN | | Bait Gene Name | ANGEL1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 507-513 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification | | Interaction ID | 22184 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23814182 | | Comments | The eIF4E binding YxxxxL motif found in human protein angel homolog 1 (ANGEL1) that mediates binding to the Eukaryotic translation initiation factor 4E (EIF4E) |
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