Query   'FHA domain'  matched   10 Records

Record No : 1

Instance ID11165
Regular Expressionxx(T)xx[ILV]x
Motif InstanceAYTLKVD
Bait Uniprot AccessionQ9SYQ8
Bait Uniprot IdentifierCLV1_ARATH
Bait Gene NameCLV1
Bait OrganismArabidopsis thaliana (Mouse-ear cress)
Sequence Position866-872
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)NMR
Interaction ID21165
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16042389
CommentsThe FHA domain from the Arabidopsis receptor kinase-associated protein phosphatase (KAPP) binds to the phosphothreonine motif in its CLV1 receptor-like kinase partner

Record No : 2

Instance ID11166
Regular Expressionxx(T)xx[ILV]x
Motif InstanceELTQELP
Bait Uniprot AccessionP14737
Bait Uniprot IdentifierRAD9_YEAST
Bait Gene NameRAD9
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position601-607
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)SPR; NMR
Interaction ID21166
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11846568
CommentsThe FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif from the yeast DNA repair protein RAD9

Record No : 3

Instance ID11167
Regular Expressionxx(T)xx[ILV]x
Motif InstanceVETTSVF
Bait Uniprot AccessionP9WJA9
Bait Uniprot IdentifierGARA_MYCTU
Bait Gene NamegarA
Bait OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Sequence Position19-25
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)NMR; ITC
Interaction ID21167
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19318624
CommentsPhosphorylation of a threonine residue within a conserved amino-terminal motif of Glycogen accumulation regulator garA/Rv1827 triggers its intramolecular association with its FHA domain in Mycobacterium tuberculosis

Record No : 4

Instance ID11168
Regular Expressionxx(T)xx[ILV]x
Motif InstancePDTLEIY
Bait Uniprot AccessionP34217
Bait Uniprot IdentifierPIN4_YEAST
Bait Gene NamePIN4
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position303-309
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)NMR; Mutation analysis; Co-IP; Y2H
Interaction ID21168
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16231900, 15024067
CommentsThe FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif from the yeast RNA-binding protein PIN4/MDT1

Record No : 5

Instance ID11169
Regular Expressionxx(T)xx[DE]x
Motif InstanceESTDEES
Bait Uniprot AccessionQ13426
Bait Uniprot IdentifierXRCC4_HUMAN
Bait Gene NameXRCC4
Bait OrganismHomo sapiens (Human)
Sequence Position231-237
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag); ITC; Fluorescence polarization spectroscopy
Interaction ID21169
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15385968
CommentsHuman Bifunctional polynucleotide phosphatase/kinase PNKP functions in Nonhomologous end joining (NHEJ) via an FHA domain-dependent interaction with a phosphothreonine motif of human DNA repair protein XRCC4

Record No : 6

Instance ID11170
Regular Expressionxx(T)xx[DE]x
Motif InstanceVPTQLDS
Bait Uniprot AccessionQ9P7T4
Bait Uniprot IdentifierMRC1_SCHPO
Bait Gene Namemrc1
Bait OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Sequence Position643-649
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID21170
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14585996
CommentsPhosphorylation of a threonine residue (T645) in DNA replication checkpoint mediator mrc1 mediates its association with Checkpoint kinase cds1 in fission yeast

Record No : 7

Instance ID11171
Regular Expressionxx(T)xx[DE]x
Motif InstanceGSTDEES
Bait Uniprot AccessionQ924T3
Bait Uniprot IdentifierXRCC4_MOUSE
Bait Gene NameXrcc4
Bait OrganismMus musculus (Mouse)
Sequence Position229-235
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography
Interaction ID21171
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15749016
CommentsMouse Bifunctional polynucleotide phosphatase/kinase Pnkp is recruited to repair complexes through interactions between its N-terminal FHA domain and a phosphorylated threonine residue (T231) in mouse DNA repair protein Xrcc4

Record No : 8

Instance ID11172
Regular Expressionxx(T)xx[DE]x
Motif InstanceFQTPTDP
Bait Uniprot AccessionP14737
Bait Uniprot IdentifierRAD9_YEAST
Bait Gene NameRAD9
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position153-159
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)NMR; SPR
Interaction ID21172
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11846567
CommentsThe FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif (153-159) from the yeast DNA repair protein RAD9

Record No : 9

Instance ID11173
Regular Expressionxx(T)xx[DE]x
Motif InstanceEVTEADA
Bait Uniprot AccessionP14737
Bait Uniprot IdentifierRAD9_YEAST
Bait Gene NameRAD9
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position190-196
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)NMR; SPR
Interaction ID21173
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11846567
CommentsThe FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif (190-196) from the yeast DNA repair protein RAD9

Record No : 10

Instance ID11174
Regular Expressionxx(T)xx[DE]x
Motif InstanceENTDSEE
Bait Uniprot AccessionP18887
Bait Uniprot IdentifierXRCC1_HUMAN
Bait Gene NameXRCC1
Bait OrganismHomo sapiens (Human)
Sequence Position521-527
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)Fluorescence polarization spectroscopy; Mutation analysis
Interaction ID21174
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15367657
CommentsThe FHA domain of human Bifunctional polynucleotide phosphatase/kinase PNKP binds to a phosphothreonine motif (T523) from human DNA repair protein XRCC1


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)