Query   'Leucine-rich repeats (LRR)'  matched   3 Records

Record No : 1

Instance ID10827
Regular Expressionxx[DE]x(T)PxK
Motif InstanceSVEQTPRK
Bait Uniprot AccessionP49918
Bait Uniprot IdentifierCDN1C_HUMAN
Bait Gene NameCDKN1C
Bait OrganismHomo sapiens (Human)
Sequence Position306-313
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Knock out; Co-IP; Alanine scanning
Interaction ID20827
Interacting DomainLeucine-rich repeats (LRR)
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12925736
CommentsThe phospho-dependent degron in Human Cyclin-dependent kinase inhibitor 1C or p57Kip2 (CDKN1C) is recognised by Human F-box/LRR-repeat protein SKP2, which is responsible for regulating the cellular level of p57Kip2 by targeting it for ubiquitylation and proteolysis

Record No : 2

Instance ID10828
Regular Expressionxx[DE]x(T)PxK
Motif InstanceAVEQTPRK
Bait Uniprot AccessionP49919
Bait Uniprot IdentifierCDN1C_MOUSE
Bait Gene NameCdkn1c
Bait OrganismMus musculus (Mouse)
Sequence Position338-345
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Knock out; Co-IP; Alanine scanning
Interaction ID20828
Interacting DomainLeucine-rich repeats (LRR)
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12925736
CommentsThe phospho-dependent degron in Mouse Cyclin-dependent kinase inhibitor 1C or p57Kip2 (Cdkn1c) is recognised by Mouse F-box/LRR-repeat protein Skp2, which is responsible for regulating the cellular level of p57Kip2 by targeting it for ubiquitylation and proteolysis

Record No : 3

Instance ID10829
Regular Expressionxx[DE]x(T)PxK
Motif InstanceSVEQTPKK
Bait Uniprot AccessionP46527
Bait Uniprot IdentifierCDN1B_HUMAN
Bait Gene NameCDKN1B
Bait OrganismHomo sapiens (Human)
Sequence Position183-190
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Mutation analysis; X-ray crystallography
Interaction ID20829
Interacting DomainLeucine-rich repeats (LRR)
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16209941
CommentsThe phospho-dependent degron in Human Cyclin-dependent kinase inhibitor 1B or p27Kip1 (CDKN1B) is recognised by Human F-box/LRR-repeat protein SKP2 depending on Thr-187 phosphorylation and causing ubiquitin-mediated proteolysis of the Cdk2 inhibitor p27Kip1


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)