Query   'PAH2 domain'  matched   7 Records

Record No : 1

Instance ID10925
Regular Expression[LIV]xx[LM]LxAAx[FY][LI]
Motif InstanceIQMLLEAADYL
Bait Uniprot AccessionQ05195
Bait Uniprot IdentifierMAD1_HUMAN
Bait Gene NameMXD1
Bait OrganismHomo sapiens (Human)
Sequence Position9-19
Critical ResiduesP2; P6; P9
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)NMR; Mutation analysis
Interaction ID20925
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15235594, 11101889
CommentsThe N-terminal region of human Max dimerization protein 1 (MXD1) binds the second paired amphipathic helix (PAH) domain (PAH2) of mouse Transcriptional corepressor Sin3a through a novel helical fold

Record No : 2

Instance ID10926
Regular Expression[FHYM]xA[AV]x[VAC]L[MV]x[MI]
Motif InstanceFEAVEALMSM
Bait Uniprot AccessionQ13118
Bait Uniprot IdentifierKLF10_HUMAN
Bait Gene NameKLF10
Bait OrganismHomo sapiens (Human)
Sequence Position39-48
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Pull down(GST tag)
Interaction ID20926
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11438660
CommentsA conserved alpha-helical motif in the human Krueppel-like factor 10 (KLF10/TIEG1) that specifically associates with the second paired amphipathic helix (PAH2) domain of mouse Transcriptional corepressor Sin3a

Record No : 3

Instance ID10927
Regular Expression[FHYM]xA[AV]x[VAC]L[MV]x[MI]
Motif InstanceMEAVEALVCM
Bait Uniprot AccessionO14901
Bait Uniprot IdentifierKLF11_HUMAN
Bait Gene NameKLF11
Bait OrganismHomo sapiens (Human)
Sequence Position45-54
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Pull down(GST tag)
Interaction ID20927
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11438660
CommentsA conserved alpha-helical motif located within the repression domain (R1) of human Krueppel-like factor 11 (KLF11/TIEG2) specifically associates with the second paired amphipathic helix (PAH2) domain of mouse Transcriptional corepressor Sin3a

Record No : 4

Instance ID10928
Regular Expression[FHYM]xA[AV]x[VAC]L[MV]x[MI]
Motif InstanceHFAAECLVSM
Bait Uniprot AccessionQ9Y2Y9
Bait Uniprot IdentifierKLF13_HUMAN
Bait Gene NameKLF13
Bait OrganismHomo sapiens (Human)
Sequence Position9-18
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis
Interaction ID20928
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11477107
CommentsThe human Transcription factor BTEB3 inhibits transcription via the basic transcription element (BTE) box, a well characterized GC-rich DNA element, by interacting with the PAH2 domain of mouse Transcriptional corepressor Sin3a

Record No : 5

Instance ID10929
Regular Expression[FA]x[LA][LV][LVI]xx[AM]
Motif InstanceAAAVLSNM
Bait Uniprot AccessionP39001
Bait Uniprot IdentifierUME6_YEAST
Bait Gene NameUME6
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position523-530
Critical ResiduesP5; P6; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis
Interaction ID20929
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11238941
CommentsThe DNA-binding Transcriptional regulatory protein Ume6 of Saccharomyces cerevisiae is required for both repression and activation of meiosis-specific genes, through interaction with the yeast Sin3 corepressor

Record No : 6

Instance ID10930
Regular Expression[FA]x[LA][LV][LVI]xx[AM]
Motif InstanceFQLLVDVA
Bait Uniprot AccessionQ15583
Bait Uniprot IdentifierTGIF1_HUMAN
Bait Gene NameTGIF1
Bait OrganismHomo sapiens (Human)
Sequence Position379-386
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Y2H
Interaction ID20930
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11571228
CommentsThe Human homeodomain protein TG-interacting factor (TGIF) interacts directly with the PAH2 domain of mouse Transcriptional corepressor Sin3a and thereby recruits mSin3 to a TGFbeta-activated Smad complex

Record No : 7

Instance ID11989
Regular Expression[LIV]xx[LM]LxAAx[FY][LI]
Motif InstanceIETLLEAARFL
Bait Uniprot AccessionO08789
Bait Uniprot IdentifierMNT_MOUSE
Bait Gene NameMnt
Bait OrganismMus musculus (Mouse)
Sequence Position3-13
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag)
Interaction ID21989
Interacting DomainPAH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)9000049
CommentsThe amino-terminal region of mouse Max-binding protein Mnt mediates interaction with mouse Transcriptional corepressor Sin3a and its deletion converts Mnt from a repressor to an activator


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)