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Query   'PCNA, C-terminal domain'  matched   21 Records

Record No : 1

Instance ID10249
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceMRVTDFFSQSKRG
Bait Uniprot AccessionQ9I9A7
Bait Uniprot IdentifierCDT1_XENLA
Bait Gene Namecdt1
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position4-16
Critical ResiduesP4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Co-IP; Ubiquitinase assay; Western blot; Alanine scanning; Mutation analysis
Interaction ID20249
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19595719
CommentsDocking of a specialized PIP Box motif of Xenopus DNA replication factor Cdt1 onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2

Record No : 2

Instance ID10251
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstancePLISDFFAKRKRS
Bait Uniprot AccessionP49918
Bait Uniprot IdentifierCDN1C_HUMAN
Bait Gene NameCDKN1C
Bait OrganismHomo sapiens (Human)
Sequence Position270-282
Critical ResiduesP5; P7; P9; P10
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; Co-IP
Interaction ID20251
Interacting DomainPCNA, C-terminal domain
Disease Association(s)IMAGe syndrome
Inhibitor(s)Unknown
Reference(s)22634751
CommentsPIP box motif in human Cyclin-dependent kinase inhibitor p57 (CDKN1C) that is required to bind PCNA

Record No : 3

Instance ID10252
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceRRVTDFFARRRP
Bait Uniprot AccessionQ9H211
Bait Uniprot IdentifierCDT1_HUMAN
Bait Gene NameCDT1
Bait OrganismHomo sapiens (Human)
Sequence Position4-15
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference;Western blot; Co-IP
Interaction ID20252
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16861906
CommentsThe human homologue of Drosophila L2DTL or fission yeast CDT2 (DTL) interacts with PCNA and regulates human DNA replication factor CDT1 proteolysis in response to DNA damage, through the conserved PIP box motif

Record No : 4

Instance ID10254
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceTSMTDFYHSKRRL
Bait Uniprot AccessionP38936
Bait Uniprot IdentifierCDN1A_HUMAN
Bait Gene NameCDKN1A
Bait OrganismHomo sapiens (Human)
Sequence Position145-157
Critical ResiduesP10; P11; P12
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP
Interaction ID20254
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18703516, 18794347
CommentsPCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis

Record No : 5

Instance ID10256
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceRKLTDFYPVRRS
Bait Uniprot AccessionQ9NQR1
Bait Uniprot IdentifierSETD8_HUMAN
Bait Gene NameSETD8
Bait OrganismHomo sapiens (Human)
Sequence Position220-231
Critical ResiduesP6; P7
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay
Interaction ID20256
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20932472, 21220508
CommentsCDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase

Record No : 6

Instance ID10258
Regular Expression[NQ]{0,1}xx[ILMV]T[DEN][HMFY][FMY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceNDITNYYKVKRRP
Bait Uniprot AccessionQ27368
Bait Uniprot IdentifierE2F_DROME
Bait Gene NameE2f
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position151-163
Critical ResiduesP3; P6; P7
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference; Mutation disrupting interaction; Fluorescence-activated cell sorting; Co-IP; Alanine scanning
Interaction ID20258
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19081076
CommentsS phase-specific destruction of Drosophila E2f1 is mediated by a PCNA-interacting-protein (PIP) motif in E2f1

Record No : 7

Instance ID10611
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQGTLESFFKR
Bait Uniprot AccessionP47110
Bait Uniprot IdentifierDPOD3_YEAST
Bait Gene NamePOL32
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position338-347
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20611
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14594808
CommentsThe C-terminal PCNA binding PIP box motif of POL32, the third subunit of Saccharomyces cerevisiae DNA polymerase delta (Pol delta), that mediates interactions with the carboxyl-terminal region of the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 8

Instance ID10612
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQKTLYSFFSP
Bait Uniprot AccessionP13051
Bait Uniprot IdentifierUNG_HUMAN
Bait Gene NameUNG
Bait OrganismHomo sapiens (Human)
Sequence Position4-13
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)SPOT assay; Y2H; ELISA
Interaction ID20612
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10393198
CommentsThe PCNA binding PIP box motif in human Uracil-DNA glycosylase (UNG) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

Record No : 9

Instance ID10613
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQTTITSHFAK
Bait Uniprot AccessionP26358
Bait Uniprot IdentifierDNMT1_HUMAN
Bait Gene NameDNMT1
Bait OrganismHomo sapiens (Human)
Sequence Position164-173
Critical ResiduesP1; P3; P4; P7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutational analysis; Competition binding assay; Pull down(GST tag)
Interaction ID20613
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9302295
CommentsThe PCNA-binding motif in human DNA–(cytosine-5) methyltransferase (MCMT) that mediates its interaction with human Proliferating cell nuclear antigen (PCNA)

Record No : 10

Instance ID10614
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceMQRSIMSFFHP
Bait Uniprot AccessionP18858
Bait Uniprot IdentifierDNLI1_HUMAN
Bait Gene NameLIG1
Bait OrganismHomo sapiens (Human)
Sequence Position1-11
Critical ResiduesP8; P9
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; Co-IP; Pull down(GST tag)
Interaction ID20614
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9649448
CommentsThe PCNA binding PIP box motif in human DNA ligase 1 (LIG1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

Record No : 11

Instance ID10615
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQGRLDGFFQV
Bait Uniprot AccessionP26793
Bait Uniprot IdentifierFEN1_YEAST
Bait Gene NameRAD27
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position340-349
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis
Interaction ID20615
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10409728
CommentsThe PCNA binding PIP box motif in Saccharomyces cerevisiae Flap endonuclease 1 (Fen1/Rad27) that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 12

Instance ID10616
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQQTLSSFFMG
Bait Uniprot AccessionP38766
Bait Uniprot IdentifierRRM3_YEAST
Bait Gene NameRRM3
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position35-44
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Y2H; Pull down
Interaction ID20616
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12239216
CommentsThe PCNA binding PIP box motif in Saccharomyces cerevisiae ATP-dependent DNA helicase RRM3 that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 13

Instance ID10617
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQATLARFFTS
Bait Uniprot AccessionP04819
Bait Uniprot IdentifierDNLI1_YEAST
Bait Gene NameCDC9
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position38-47
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)SPR; Pull down; X-ray crystallography
Interaction ID20617
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17308348
CommentsThe conserved PCNA interaction motif of Cdc9, yeast DNA ligase I, that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 14

Instance ID10618
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQVSITGFFQR
Bait Uniprot AccessionQ15054
Bait Uniprot IdentifierDPOD3_HUMAN
Bait Gene NamePOLD3
Bait OrganismHomo sapiens (Human)
Sequence Position456-465
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography
Interaction ID20618
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15576034
CommentsThe PCNA binding PIP box motif in human DNA polymerase delta subunit 3 (POLD3) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

Record No : 15

Instance ID10619
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQLRIDSFFRL
Bait Uniprot AccessionP28715
Bait Uniprot IdentifierERCC5_HUMAN
Bait Gene NameERCC5
Bait OrganismHomo sapiens (Human)
Sequence Position990-999
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; Competition binding assay; Pull down(GST tag)
Interaction ID20619
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9305916
CommentsThe PCNA binding PIP box motif in human DNA excision repair protein ERCC-5, a structure-specific endonuclease involved in DNA replication, that mediates its interaction with Proliferating cell nuclear antigen (PCNA)

Record No : 16

Instance ID10620
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQTSMTDFYHS
Bait Uniprot AccessionP38936
Bait Uniprot IdentifierCDN1A_HUMAN
Bait Gene NameCDKN1A
Bait OrganismHomo sapiens (Human)
Sequence Position144-153
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography
Interaction ID20620
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8861913
CommentsThe C-terminal PCNA binding PIP box motif of human Cyclin-dependent kinase inhibitor 1 (CDKN1A/p21/WAF1/CIP1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

Record No : 17

Instance ID10621
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQTTIEDFFGT
Bait Uniprot AccessionP12887
Bait Uniprot IdentifierUNG_YEAST
Bait Gene NameUNG1
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position21-30
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID20621
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12239216
CommentsThe predicted PCNA binding PIP box motif in Saccharomyces cerevisiae Uracil-DNA glycosylase (UNG1) that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 18

Instance ID10622
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQKSIMSFFGK
Bait Uniprot AccessionP30261
Bait Uniprot IdentifierDPOD3_SCHPO
Bait Gene Namecdc27
Bait OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Sequence Position362-371
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H; Co-IP; Pull down(GST tag); Western blot
Interaction ID20622
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10698951
CommentsEssential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal PCNA binding PIP box motif

Record No : 19

Instance ID10623
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQSSLLSFFSK
Bait Uniprot AccessionQ03834
Bait Uniprot IdentifierMSH6_YEAST
Bait Gene NameMSH6
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position27-36
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Mutation analysis
Interaction ID20623
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11062484
CommentsThe N-terminal PCNA binding PIP box motif of Saccharomyces cerevisiae DNA mismatch repair protein MSH6 that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 20

Instance ID10624
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQGRLDDFFKV
Bait Uniprot AccessionP39748
Bait Uniprot IdentifierFEN1_HUMAN
Bait Gene NameFEN1
Bait OrganismHomo sapiens (Human)
Sequence Position337-346
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography; Peptide mapping; Y2H; Co-IP; Competition binding assay
Interaction ID20624
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15576034, 9178907
CommentsThe PCNA binding PIP box motif in human Flap endonuclease 1 (FEN1)/ DNase IV that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

Record No : 21

Instance ID10625
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQKRINEFFPR
Bait Uniprot AccessionP07276
Bait Uniprot IdentifierRAD2_YEAST
Bait Gene NameRAD2
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position995-1004
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID20625
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11545742
CommentsThe predicted PCNA binding PIP box motif in Saccharomyces cerevisiae DNA polymerase (Pol) eta/ DNA repair protein RAD2 that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30), which is essential for the in vivo function of Poleta




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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)