Query 'PIF-binding pocket' matched 17 Records
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Record No : 1 |
| Instance ID | 10114 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FVGFTY | | Bait Uniprot Accession | Q13464 | | Bait Uniprot Identifier | ROCK1_HUMAN | | Bait Gene Name | ROCK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 394-399 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20114 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18204440 | | Comments | PDK1 competes directly with RhoE for binding to human ROCK1 through the AGC Kinase docking motif that interacts with the PIF pocket of PDK1, thus altering the localization of ROCK1 and reducing its ability to drive cortical acto-myosin contraction |
Record No : 2 |
| Instance ID | 10115 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FRGFSF | | Bait Uniprot Accession | P18654 | | Bait Uniprot Identifier | KS6A3_MOUSE | | Bait Gene Name | Rps6ka3 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 382-387 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Co-IP; Mutation analysis | | Interaction ID | 20115 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10856237 | | Comments | Hydrophobic motif of the 90 kDa ribosomal S6 kinase-2 (RSK2), a growth factor-stimulated protein kinase, that acts as a phosphorylation-dependent docking site and activator of PDK1 |
Record No : 3 |
| Instance ID | 10116 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FLGFTY | | Bait Uniprot Accession | P67999 | | Bait Uniprot Identifier | KS6B1_RAT | | Bait Gene Name | Rps6kb1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 408-413 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR | | Interaction ID | 20116 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11500365 | | Comments | Phosphorylation of the hydrophobic motif of p70 ribosomal S6 kinase 1 promotes its interaction with the PIF-binding pocket of PDK1 |
Record No : 4 |
| Instance ID | 10117 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FLGFSY | | Bait Uniprot Accession | O00141 | | Bait Uniprot Identifier | SGK1_HUMAN | | Bait Gene Name | SGK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 418-423 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR | | Interaction ID | 20117 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11500365 | | Comments | Phosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk1 promotes its interaction with the PIF-binding pocket of PDK1 |
Record No : 5 |
| Instance ID | 10118 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FVGFSY | | Bait Uniprot Accession | Q96BR1 | | Bait Uniprot Identifier | SGK3_HUMAN | | Bait Gene Name | SGK3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 482-487 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Co-IP; Mutation analysis | | Interaction ID | 20118 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16790420 | | Comments | Phosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk3 promotes its interaction with the PIF-binding pocket of PDK1 |
Record No : 6 |
| Instance ID | 10119 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FAGFTF | | Bait Uniprot Accession | P11792 | | Bait Uniprot Identifier | SCH9_YEAST | | Bait Gene Name | SCH9 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 733-738 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Protein kinase assay; Mutation analysis | | Interaction ID | 20119 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21531713 | | Comments | Interaction of PKH1, the yeast ortholog of mammalian PDK1, with SCH9, the yeast S6K ortholog, depends on the hydrophobic PDK1-interacting fragment (PIF) pocket in PKH1 and requires the complementary hydrophobic motif in SCH9 |
Record No : 7 |
| Instance ID | 10120 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FVGFSY | | Bait Uniprot Accession | Q9ERE3 | | Bait Uniprot Identifier | SGK3_MOUSE | | Bait Gene Name | Sgk3 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 482-487 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy; Protein kinase assay; Mutation analysis | | Interaction ID | 20120 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14604990 | | Comments | CISK (Sgk3) and PDK-1 interact in a phosphorylation-dependent manner through the hydrophobic motif of Sgk3 and the PIF-binding pocket of PDK1 |
Record No : 8 |
| Instance ID | 10121 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FRDFDY | | Bait Uniprot Accession | Q16513 | | Bait Uniprot Identifier | PKN2_HUMAN | | Bait Gene Name | PKN2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 974-979 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography technology; Western blot; Mutation analysis; Y2H; Pull down; SPR; Competition binding | | Interaction ID | 20121 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16219676, 10698939, 10764742 | | Comments | "The hydrophobic motif in the PKC-related kinase, PRK2 (or PKN2), which acts as a ""docking site"" for recruitment of PDK1 and is essential for its phosphorylation by PDK1 in cells" |
Record No : 9 |
| Instance ID | 10122 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FEGFEY | | Bait Uniprot Accession | P41743 | | Bait Uniprot Identifier | KPCI_HUMAN | | Bait Gene Name | PRKCI | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 579-584 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20122 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in PKCiota that acts as a ""docking site"" for the recruitment of PDK1 resulting in phosphorylation at its T-loop site by PDK1 in cells" |
Record No : 10 |
| Instance ID | 10123 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FEGFEY | | Bait Uniprot Accession | Q05513 | | Bait Uniprot Identifier | KPCZ_HUMAN | | Bait Gene Name | PRKCZ | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 575-580 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20123 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in human PKCzeta that acts as a ""docking site"" for the recruitment of PDK1 resulting in phosphorylation at its T-loop site by PDK1 in cells" |
Record No : 11 |
| Instance ID | 10124 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FEGFEY | | Bait Uniprot Accession | Q02956 | | Bait Uniprot Identifier | KPCZ_MOUSE | | Bait Gene Name | Prkcz | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 575-580 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Competition binding; Mutation analysis | | Interaction ID | 20124 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in mouse PKCzeta that acts as a ""docking site"" for the recruitment of PDK1 resulting in phosphorylation at its T-loop site by PDK1 in cells" |
Record No : 12 |
| Instance ID | 10125 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FLDFDF | | Bait Uniprot Accession | Q16512 | | Bait Uniprot Identifier | PKN1_HUMAN | | Bait Gene Name | PKN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 932-937 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20125 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in the PKC-related kinase, PRK1 (or PKN1), which acts as a ""docking site"" for recruitment of PDK1 and is essential for its phosphorylation by PDK1 in cells" |
Record No : 13 |
| Instance ID | 10126 | | Regular Expression | FxxF$ | | Motif Instance | FSEF | | Bait Uniprot Accession | P17612 | | Bait Uniprot Identifier | KAPCA_HUMAN | | Bait Gene Name | PRKACA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 348-351 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20126 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10698939 | | Comments | "The C-terminal hydrophobic motif in the cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), which acts as a ""docking site"" for recruitment of PDK1" |
Record No : 14 |
| Instance ID | 10127 | | Regular Expression | FxxF$ | | Motif Instance | FEFF | | Bait Uniprot Accession | Q5I6E9 | | Bait Uniprot Identifier | Q5I6E9_SOLLC | | Bait Gene Name | Adi3 | | Bait Organism | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | | Sequence Position | 697-700 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP; Mutation analysis | | Interaction ID | 20127 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Bacterial speck disease in tomato | | Inhibitor(s) | Unknown | | Reference(s) | 16362044 | | Comments | "The C-terminal hydrophobic motif in tomato AvrPto-dependent Pto-interacting protein 3 (Adi3), which acts as a ""docking site"" for recruitment of tomato Pdk1, Adi3 thus negatively regulating cell death via Pdk1 phosphorylation" |
Record No : 15 |
| Instance ID | 10128 | | Regular Expression | FxxF$ | | Motif Instance | FLVF | | Bait Uniprot Accession | Q9LSF1 | | Bait Uniprot Identifier | OXI1_ARATH | | Bait Gene Name | OXI1 | | Bait Organism | Arabidopsis thaliana (Mouse-ear cress) | | Sequence Position | 418-421 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Co-IP; Mutation analysis | | Interaction ID | 20128 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14749726 | | Comments | "The C-terminal hydrophobic motif in Arabidopsis protein OXI1 (AGC2-1), which acts as a ""docking site"" for recruitment of Arabidopsis PDK1" |
Record No : 16 |
| Instance ID | 10129 | | Regular Expression | FxxF$ | | Motif Instance | FTEF | | Bait Uniprot Accession | P05132 | | Bait Uniprot Identifier | KAPCA_MOUSE | | Bait Gene Name | Prkaca | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 348-351 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Protein kinase assay; Mutation analysis | | Interaction ID | 20129 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15299527, 12372837 | | Comments | "The C-terminal hydrophobic motif in cAMP-dependent protein kinase catalytic subunit alpha which acts as a ""docking site"" for its phosphorylation by Phosphoinositide-dependent kinase-1 (PDK-1)" |
Record No : 17 |
| Instance ID | 10130 | | Regular Expression | FxxF$ | | Motif Instance | FRDF | | Bait Uniprot Accession | P06244 | | Bait Uniprot Identifier | KAPA_YEAST | | Bait Gene Name | TPK1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 394-397 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20130 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21531713 | | Comments | "The C-terminal hydrophobic motif in yeast Tpk1, the catalytic subunit of protein kinase A, which acts as a ""docking site"" for its phosphorylation by PKH1, the yeast ortholog of mammalian PDK1" |
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