Query   'PUB domain'  matched   3 Records

Record No : 1

Instance ID12052
Regular Expression[DE][DE][ILVM]Yx
Motif InstanceDDLYG
Bait Uniprot AccessionQ01853
Bait Uniprot IdentifierTERA_MOUSE
Bait Gene NameVcp
Bait OrganismMus musculus (Mouse)
Sequence Position802-806
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; ITC
Interaction ID22052
Interacting DomainPUB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17496150
CommentsThe c-terminal cofactor-binding motif of mouse Transitional endoplasmic reticulum ATPase p97 subunit (VCP) that is both necessary and sufficient to mediate its interactions with mouse Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase)

Record No : 2

Instance ID12053
Regular Expression[DE][DE][ILVM]Yx
Motif InstanceDDLYG
Bait Uniprot AccessionP55072
Bait Uniprot IdentifierTERA_HUMAN
Bait Gene NameVCP
Bait OrganismHomo sapiens (Human)
Sequence Position802-806
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; ITC; Pull down(GST tag)
Interaction ID22053
Interacting DomainPUB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24726327
CommentsThe c-terminal PUB interacting motif (PIM) of human Transitional endoplasmic reticulum ATPase (VCP) that binds to the PUB domain of human E3 ubiquitin-protein ligase RNF31/HOIP

Record No : 3

Instance ID12054
Regular Expression[DE][DE][ILVM]Yx
Motif InstanceEDMYR
Bait Uniprot AccessionQ96BN8
Bait Uniprot IdentifierOTUL_HUMAN
Bait Gene NameOTULIN
Bait OrganismHomo sapiens (Human)
Sequence Position53-57
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureCoil
Experimental Method(s)X-ray crystallography; ITC; Mutation analysis; Co-IP; Pull down(GST tag)
Interaction ID22054
Interacting DomainPUB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24726327
CommentsThe PUB interacting motif (PIM) of human Ubiquitin thioesterase OTULIN that binds to the PUB domain of human E3 ubiquitin-protein ligase RNF31/HOIP


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)