LMPID

Home About Browse Help Download

Query 'Rb pocket AB groove' matched 3 Records

Record No : 1

Instance ID	10807
Regular Expression	xx[LIMV]xx[LM][FY]Dx
Motif Instance	EGIRDLFDC
Bait Uniprot Accession	Q01094
Bait Uniprot Identifier	E2F1_HUMAN
Bait Gene Name	E2F1
Bait Organism	Homo sapiens (Human)
Sequence Position	419-427
Critical Residues	Unknown
Motif PTM(s)	Unknown
Secondary Structure	Unknown
Experimental Method(s)	Mutation analysis; Y2H; Pull down(GST tag); Competition binding
Interaction ID	20807
Interacting Domain	Rb pocket AB groove
Disease Association(s)	Unknown
Inhibitor(s)	Unknown
Reference(s)	8346196, 8413249
Comments	Human RB suppresses Transcription factor E2F1-mediated transcriptional activation through direct physical association via the LxxLFD retinoblastoma (RB)-binding sequence

Record No : 2

Instance ID	10808
Regular Expression	xx[LIMV]xx[LM][FY]Dx
Motif Instance	EGISDLFDS
Bait Uniprot Accession	Q14209
Bait Uniprot Identifier	E2F2_HUMAN
Bait Gene Name	E2F2
Bait Organism	Homo sapiens (Human)
Sequence Position	420-428
Critical Residues	P1; P2; P7
Motif PTM(s)	Unknown
Secondary Structure	3(10)-helix
Experimental Method(s)	X-ray crystallography; Mutation analysis; ITC
Interaction ID	20808
Interacting Domain	Rb pocket AB groove
Disease Association(s)	Unknown
Inhibitor(s)	Unknown
Reference(s)	12502741
Comments	Human RB suppresses Transcription factor E2F2-mediated transcriptional activation through direct physical association via the LxxLFD retinoblastoma (RB)-binding sequence

Record No : 3

Instance ID	10809
Regular Expression	xx[LIMV]xx[LM][FY]Dx
Motif Instance	PTLHELYDL
Bait Uniprot Accession	P03255
Bait Uniprot Identifier	E1A_ADE05
Bait Gene Name	Not Available
Bait Organism	Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Sequence Position	41-49
Critical Residues	P3; P4; P7
Motif PTM(s)	Unknown
Secondary Structure	Unknown
Experimental Method(s)	Mutation analysis; ITC; Pull down(GST tag); X-ray crystallography
Interaction ID	20809
Interacting Domain	Rb pocket AB groove
Disease Association(s)	Unknown
Inhibitor(s)	Unknown
Reference(s)	1534854, 17974914
Comments	The LxxLFD retinoblastoma (RB)-binding sequence in the amino terminus of Human adenovirus Early E1A 32 kDa protein that mediates binding to the human retinoblastoma protein (RB)

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)