Query 'SH3 domain' matched 153 Records
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Record No : 1 |
| Instance ID | 10875 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | KPLPPTP | | Bait Uniprot Accession | Q06187 | | Bait Uniprot Identifier | BTK_HUMAN | | Bait Gene Name | BTK | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 186-192 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Alanine scanning; GPC; NMR | | Interaction ID | 20875 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11707259 | | Comments | Proline-rich SH3-binding sequence (186-192) in the TH region of Bruton tyrosine kinase (BTK) that stabilize intermolecular self-association with the SH3 domain of another BTK molecule |
Record No : 2 |
| Instance ID | 10876 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | KPLPPEP | | Bait Uniprot Accession | Q06187 | | Bait Uniprot Identifier | BTK_HUMAN | | Bait Gene Name | BTK | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 200-206 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Alanine scanning; GPC; NMR | | Interaction ID | 20876 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11707259 | | Comments | Proline-rich SH3-binding sequence (200-206) in the TH region of Bruton tyrosine kinase (BTK) that stabilize intermolecular self-association with the SH3 domain of another BTK molecule |
Record No : 3 |
| Instance ID | 10877 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | YDSPCLP | | Bait Uniprot Accession | Q06609 | | Bait Uniprot Identifier | RAD51_HUMAN | | Bait Gene Name | RAD51 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 315-321 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20877 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 21653319 | | Comments | Human BCR-ABL1 SH3 domain interacts with the proline-rich SH3-binding sequence of human DNA repair protein RAD51, resulting in direct phosphorylation of RAD51 on Y315, which migrates to the nucleus, and enhances formation of the nuclear foci indicative of recombination sites |
Record No : 4 |
| Instance ID | 10878 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | KPRPPRP | | Bait Uniprot Accession | P27986 | | Bait Uniprot Identifier | P85A_HUMAN | | Bait Gene Name | PIK3R1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 88-94 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down; Competition binding | | Interaction ID | 20878 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8294442 | | Comments | Proline-rich SH3-binding sequence (88-94) in human PI3-kinase regulatory subunit p85-alpha that associates with the SH3 domain of human Proto-oncogene c-Fyn |
Record No : 5 |
| Instance ID | 10879 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | RTPPKSP | | Bait Uniprot Accession | P10636 | | Bait Uniprot Identifier | TAU_HUMAN | | Bait Gene Name | MAPT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 547-553 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20879 | | Interacting Domain | SH3 domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 9763511 | | Comments | Proline-rich SH3-binding sequence in the amino terminus of human Microtubule-associated protein tau (MAPT) that interacts with the SH3 domain of human Tyrosine-protein kinase Fyn and may have a role in neuropathogenesis |
Record No : 6 |
| Instance ID | 10880 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1151-1156 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | ITC; Pull down; Co-IP; Competition binding | | Interaction ID | 20880 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8479541, 23334917 | | Comments | The SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling |
Record No : 7 |
| Instance ID | 10881 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVPPRR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1152-1157 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20881 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8479541 | | Comments | The SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling |
Record No : 8 |
| Instance ID | 10882 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAPPMR | | Bait Uniprot Accession | P35465 | | Bait Uniprot Identifier | PAK1_RAT | | Bait Gene Name | Pak1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 13-18 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down(GST tag); SPR | | Interaction ID | 20882 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10805734 | | Comments | The N-terminal sequence of rat Serine/threonine-protein kinase Pak1/Alpha-PAK that allows it to bind to the SH3 domain of the rat adaptor protein Nck1 |
Record No : 9 |
| Instance ID | 10883 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPLPER | | Bait Uniprot Accession | P29352 | | Bait Uniprot Identifier | PTN22_MOUSE | | Bait Gene Name | Ptpn22 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 614-619 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Mutation analysis | | Interaction ID | 20883 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11685249, 9582365 | | Comments | Mouse C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched PEST domain of mouse tyrosine phosphatase PEP in hematopoietic cells |
Record No : 10 |
| Instance ID | 10884 | | Regular Expression | PxxPx[KR] | | Motif Instance | PQVPLR | | Bait Uniprot Accession | P03406 | | Bait Uniprot Identifier | NEF_HV1BR | | Bait Gene Name | nef | | Bait Organism | Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) | | Sequence Position | 72-77 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Alanine scanning; Western blot; X-ray crystallography | | Interaction ID | 20884 | | Interacting Domain | SH3 domain | | Disease Association(s) | Human immunodeficiency virus (HIV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 7859737, 8681387 | | Comments | Proline-rich (PxxP) motif in HIV-1 Nef that binds to the SH3 domain of human Tyrosine-protein kinase Fyn and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4 |
Record No : 11 |
| Instance ID | 10885 | | Regular Expression | PxxPx[KR] | | Motif Instance | PTLPHR | | Bait Uniprot Accession | P53112 | | Bait Uniprot Identifier | PEX14_YEAST | | Bait Gene Name | PEX14 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 87-92 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Y2H; Mutation analysis | | Interaction ID | 20885 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12453410, 10087260 | | Comments | The SH3 domain of Saccharomyces cerevisiae Peroxisomal membrane protein PAS20/Pex13p binds to PPII-helical ligand from yeast Peroxisomal membrane protein Pex14p |
Record No : 12 |
| Instance ID | 10886 | | Regular Expression | PxxPx[KR] | | Motif Instance | PALPPK | | Bait Uniprot Accession | Q13905 | | Bait Uniprot Identifier | RPGF1_HUMAN | | Bait Gene Name | RAPGEF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 284-289 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20886 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7735837 | | Comments | The SH3 domain of Proto-oncogene c-Crk engages in an unusual lysine-specific interaction to bind the lysine-containing proline-rich peptide from the guanine nucleotide exchange factor C3G with high affinity |
Record No : 13 |
| Instance ID | 10887 | | Regular Expression | PxxPx[KR] | | Motif Instance | PALPPK | | Bait Uniprot Accession | P27986 | | Bait Uniprot Identifier | P85A_HUMAN | | Bait Gene Name | PIK3R1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 305-310 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Competition binding; Pull down | | Interaction ID | 20887 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8294442 | | Comments | Proline-rich SH3-binding sequence (305-310) in human PI3-kinase regulatory subunit p85-alpha that associates with the SH3 domain of human Proto-oncogene c-Fyn |
Record No : 14 |
| Instance ID | 10888 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPKPPK | | Bait Uniprot Accession | P27986 | | Bait Uniprot Identifier | P85A_HUMAN | | Bait Gene Name | PIK3R1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 308-313 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down | | Interaction ID | 20888 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8294442 | | Comments | Proline-rich SH3-binding sequence (308-313) in human PI3-kinase regulatory subunit p85-alpha that associates with the SH3 domain of human Proto-oncogene c-Fyn |
Record No : 15 |
| Instance ID | 10889 | | Regular Expression | PxxPx[KR] | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20889 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9148966 | | Comments | The SH3 domain of Human neuronal protein Amphiphysin binds with high affinity to a single site (833-838) in the long proline-rich region of human Dynamin-1 |
Record No : 16 |
| Instance ID | 10890 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPKPSR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 750-755 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Pull down; Y2H | | Interaction ID | 20890 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662921, 7479864 | | Comments | The SH3 domain of Mouse p130cas (CRK-associated substrate) or Bcar1 binds to a proline-rich sequence present in the C terminus of Mouse pp125FAK/ Focal adhesion kinase 1 (Fak1)/ Protein-tyrosine kinase 2 (Ptk2), a kinase which is activated upon cell adhesion, and this interaction is likely to be functionally important in integrin mediated signal transduction |
Record No : 17 |
| Instance ID | 10891 | | Regular Expression | PxxPx[KR] | | Motif Instance | PIPPPR | | Bait Uniprot Accession | P26662 | | Bait Uniprot Identifier | POLG_HCVJA | | Bait Gene Name | Not Available | | Bait Organism | Hepatitis C virus genotype 1b (isolate Japanese) (HCV) | | Sequence Position | 2323-2328 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Confocal microscopy; Pull down; Y2H; Co-IP | | Interaction ID | 20891 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19656877, 16530520 | | Comments | The SH3 binding motif of hepatitis C virus (HCV) nonstructural protein 5A (NS5A) interacts with Human BIN1, a tumor suppressor with pro-apoptotic properties, and is important for apoptosis and infectivity as well as may contribute to the pathogenesis of hepatocellular carcinoma |
Record No : 18 |
| Instance ID | 10892 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAVPPR | | Bait Uniprot Accession | P14598 | | Bait Uniprot Identifier | NCF1_HUMAN | | Bait Gene Name | NCF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 363-368 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Pull down | | Interaction ID | 20892 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15657040, 9121467 | | Comments | The polyproline motif in human Neutrophil cytosol factor 1 (NCF1) or p47-phox that can interact with the SH3 domain of human Neutrophil cytosol factor 4 (NCF4) or p40-phox |
Record No : 19 |
| Instance ID | 10893 | | Regular Expression | PxxPx[KR] | | Motif Instance | PLSPSR | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 60-65 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Y2H | | Interaction ID | 20893 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15992821 | | Comments | The consensus class II SH3-binding motif in the N terminus of the Human c-Myc oncoprotein interacts with the C-terminal SH3 domain of human BIN1, a ubiquitously expressed nucleocytoplasmic protein with features of a tumor suppressor |
Record No : 20 |
| Instance ID | 10894 | | Regular Expression | PxxPx[KR] | | Motif Instance | PQIPSR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 829-834 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Competition binding; SPR; Pull down | | Interaction ID | 20894 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15483625 | | Comments | The consensus class II SH3-binding motif in Human Dynamin-2 that interacts with the SH3 domain of Human Myc box-dependent-interacting protein 1 (BIN1) |
Record No : 21 |
| Instance ID | 10895 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAPPMR | | Bait Uniprot Accession | Q13153 | | Bait Uniprot Identifier | PAK1_HUMAN | | Bait Gene Name | PAK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 13-18 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20895 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8798379 | | Comments | The association between human NCK adaptor protein 1 (NCK1) and human Serine/threonine-protein kinase PAK1 is mediated by the second SH3 domain of NCK1 and a proline-rich sequence in the amino terminus of PAK1 |
Record No : 22 |
| Instance ID | 10896 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAPPSR | | Bait Uniprot Accession | Q13444 | | Bait Uniprot Identifier | ADA15_HUMAN | | Bait Gene Name | ADAM15 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 767-772 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide array; Solid phase assay; Mutation analysis | | Interaction ID | 20896 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19718658 | | Comments | The consensus class II SH3-binding motif in Human Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), that interacts with the SH3 domain of Human Proto-oncogene tyrosine-protein kinase Src (SRC) |
Record No : 23 |
| Instance ID | 10897 | | Regular Expression | xxx[PV]xxP | | Motif Instance | YGPVLSP | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 407-413 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20897 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10391251 | | Comments | Human Proto-oncogene c-Abl (ABL1) binds to human Tumor protein p73 (TP73) via its SH3 domain and thereby stimulates p73-mediated transactivation and apoptosis in response to DNA damage |
Record No : 24 |
| Instance ID | 10898 | | Regular Expression | xxx[PV]xxP | | Motif Instance | FVSPTPP | | Bait Uniprot Accession | Q8R5H6 | | Bait Uniprot Identifier | WASF1_MOUSE | | Bait Gene Name | Wasf1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 319-325 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20898 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10970852 | | Comments | Mouse Wave1/Wasf1, a Wiskott-Aldrich syndrome protein, binds to the SH3 domain of the mouse Proto-oncogene c-Abl/Abelson tyrosine kinase (Abl) |
Record No : 25 |
| Instance ID | 10899 | | Regular Expression | xxx[PV]xxP | | Motif Instance | TPAPALP | | Bait Uniprot Accession | Q12446 | | Bait Uniprot Identifier | LAS17_YEAST | | Bait Gene Name | LAS17 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 216-222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down(GST tag) | | Interaction ID | 20899 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10648568 | | Comments | The COOH-terminal tail of yeast Myosin-3 contains an SH3 domain that interacts with yeast Bee1p (Las17p) |
Record No : 26 |
| Instance ID | 10900 | | Regular Expression | xxx[PV]xxP | | Motif Instance | TPAPALP | | Bait Uniprot Accession | Q12446 | | Bait Uniprot Identifier | LAS17_YEAST | | Bait Gene Name | LAS17 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 216-222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down(GST tag) | | Interaction ID | 20900 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10648568 | | Comments | The COOH-terminal tail of yeast Myosin-5 contains an SH3 domain that interacts with yeast Bee1p (Las17p) |
Record No : 27 |
| Instance ID | 10901 | | Regular Expression | xxx[PV]xxP | | Motif Instance | VPPPVPP | | Bait Uniprot Accession | Q62245 | | Bait Uniprot Identifier | SOS1_MOUSE | | Bait Gene Name | Sos1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1135-1141 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR | | Interaction ID | 20901 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9135122 | | Comments | Interaction between the N-terminal SH3 domain of Mouse growth factor receptor-bound protein 2 (Grb2) with the mouse Son-of-Sevenless (Sos) protein is mediated by a proline-rich peptide of the mouse Sos1 sequence |
Record No : 28 |
| Instance ID | 10902 | | Regular Expression | xxx[PV]xxP | | Motif Instance | PHVVDLP | | Bait Uniprot Accession | P69616 | | Bait Uniprot Identifier | ORF3_HEVBU | | Bait Gene Name | ORF_Name:ORF3 | | Bait Organism | Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1) | | Sequence Position | 102-108 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Y2H; Pull down | | Interaction ID | 20902 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11518702 | | Comments | The ORF3 protein of Hepatitis E virus binds to the SH3 domain of human Adapter protein GRB2 through one of its PXXP motifs (102-108) |
Record No : 29 |
| Instance ID | 10903 | | Regular Expression | xxx[PV]xxP | | Motif Instance | PHVVDLP | | Bait Uniprot Accession | P69616 | | Bait Uniprot Identifier | ORF3_HEVBU | | Bait Gene Name | ORF_Name:ORF3 | | Bait Organism | Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1) | | Sequence Position | 102-108 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Y2H; Pull down | | Interaction ID | 20903 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11518702 | | Comments | The ORF3 protein of Hepatitis E virus binds to the SH3 domain of human Proto-oncogene tyrosine-protein kinase SRC through one of its PXXP motifs (102-108) |
Record No : 30 |
| Instance ID | 10904 | | Regular Expression | xxx[PV]xxP | | Motif Instance | PTLPPRP | | Bait Uniprot Accession | P25049 | | Bait Uniprot Identifier | TIP_SHV24 | | Bait Gene Name | Not Available | | Bait Organism | Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri) | | Sequence Position | 135-141 | | Critical Residues | P1; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down | | Interaction ID | 20904 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11040125 | | Comments | A proline-rich region in Tip protein of Herpesvirus saimiri strain 484C binds to the SH3 domain and activates the human Proto-oncogene LCK |
Record No : 31 |
| Instance ID | 10905 | | Regular Expression | xxx[PV]xxP | | Motif Instance | SPLPSFP | | Bait Uniprot Accession | P03495 | | Bait Uniprot Identifier | NS1_I72A2 | | Bait Gene Name | NS | | Bait Organism | Influenza A virus (strain A/Udorn/307/1972 H3N2) | | Sequence Position | 161-167 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Co-IP; Western blot; Pull down; Mutation analysis | | Interaction ID | 20905 | | Interacting Domain | SH3 domain | | Disease Association(s) | Influenza | | Inhibitor(s) | Unknown | | Reference(s) | 17881440 | | Comments | SH3 binding motif 1 in influenza A virus NS1 protein mediate binding to the p85 subunit of Human Phosphatidylinositol 3-kinase (PI3K) and is essential for PI3K/Akt signaling pathway activation |
Record No : 32 |
| Instance ID | 10906 | | Regular Expression | xxx[PV]xxP | | Motif Instance | SHRPPPP | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 294-300 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Competition binding | | Interaction ID | 20906 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12426371 | | Comments | Interaction of membrane-proximal proline-rich motif in the human T-cell surface antigen CD2 cytoplasmic tail with the SH3 domain of human Tyrosine-protein kinase FYN |
Record No : 33 |
| Instance ID | 10907 | | Regular Expression | xxx[PV]xxP | | Motif Instance | SPPPYVP | | Bait Uniprot Accession | Q14118 | | Bait Uniprot Identifier | DAG1_HUMAN | | Bait Gene Name | DAG1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 888-894 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Solid phase assay; SPR | | Interaction ID | 20907 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Dystrophin | | Reference(s) | 10903901 | | Comments | High-affinity interaction between the SH3 domains of human Adapter protein GRB2 and a proline-rich region within human Beta-dystroglycan which is inhibited by dystrophin |
Record No : 34 |
| Instance ID | 10908 | | Regular Expression | xxx[PV]xxP | | Motif Instance | VTRPSAP | | Bait Uniprot Accession | P69616 | | Bait Uniprot Identifier | ORF3_HEVBU | | Bait Gene Name | ORF_Name:ORF3 | | Bait Organism | Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1) | | Sequence Position | 93-99 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20908 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11518702 | | Comments | The ORF3 protein of Hepatitis E virus binds to the SH3 domain of human Adapter protein GRB2 through one of its PXXP motifs (93-99) |
Record No : 35 |
| Instance ID | 10909 | | Regular Expression | xxx[PV]xxP | | Motif Instance | VTRPSAP | | Bait Uniprot Accession | P69616 | | Bait Uniprot Identifier | ORF3_HEVBU | | Bait Gene Name | ORF_Name:ORF3 | | Bait Organism | Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1) | | Sequence Position | 93-99 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20909 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11518702 | | Comments | The ORF3 protein of Hepatitis E virus binds to the SH3 domain of human Proto-oncogene tyrosine-protein kinase SRC through one of its PXXP motifs (93-99) |
Record No : 36 |
| Instance ID | 10910 | | Regular Expression | xxx[PV]xxP | | Motif Instance | PPVPPPP | | Bait Uniprot Accession | O00499 | | Bait Uniprot Identifier | BIN1_HUMAN | | Bait Gene Name | BIN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 308-314 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Classical fluorescence spectroscopy; Peptide binding to perpetrator; Y2H; NMR; Competition binding; Mutation analysis | | Interaction ID | 20910 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15992821 | | Comments | Tumor-specific isoforms of human BIN1 are precluded from interaction with c-Myc through an intramolecular polyproline-SH3 domain interaction that inhibits the BIN1 SH3 domain from binding to c-Myc |
Record No : 37 |
| Instance ID | 10911 | | Regular Expression | PxxDY | | Motif Instance | PPVDY | | Bait Uniprot Accession | Q92738 | | Bait Uniprot Identifier | US6NL_HUMAN | | Bait Gene Name | USP6NL | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 725-729 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Far-western blotting; ELISA; Pull down(GST tag) | | Interaction ID | 20911 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10508163 | | Comments | The SH3 domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) binds to the PXXDY consensus motif found in human USP6 N-terminal-like protein (USP6NL) or RN-tre |
Record No : 38 |
| Instance ID | 10912 | | Regular Expression | PxxDY | | Motif Instance | PPVDY | | Bait Uniprot Accession | Q8IZP0 | | Bait Uniprot Identifier | ABI1_HUMAN | | Bait Gene Name | ABI1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 417-421 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Far-western blotting; ELISA; Pull down(GST tag) | | Interaction ID | 20912 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10508163 | | Comments | The SH3 domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) binds to the PXXDY consensus motif found in human Abl interactor 1 (ABI1) or e3B1 |
Record No : 39 |
| Instance ID | 10913 | | Regular Expression | PxxDY | | Motif Instance | PNPDY | | Bait Uniprot Accession | P07766 | | Bait Uniprot Identifier | CD3E_HUMAN | | Bait Gene Name | CD3E | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 184-188 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Display technology; Co-IP; Mutation analysis | | Interaction ID | 20913 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17617578 | | Comments | The PxxDY motif of human T-cell surface glycoprotein CD3 epsilon (CD3E) mediates binding to the SH3 domain of human Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) |
Record No : 40 |
| Instance ID | 10914 | | Regular Expression | PxxDY | | Motif Instance | PNPDY | | Bait Uniprot Accession | P07766 | | Bait Uniprot Identifier | CD3E_HUMAN | | Bait Gene Name | CD3E | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 184-188 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Display technology; Co-IP; Mutation analysis | | Interaction ID | 20914 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17617578 | | Comments | The PxxDY motif of human T-cell surface glycoprotein CD3 epsilon (CD3E) mediates binding to the N-terminal SH3 domain of human Cytoplasmic protein NCK1 |
Record No : 41 |
| Instance ID | 10915 | | Regular Expression | PxxDY | | Motif Instance | PNPDY | | Bait Uniprot Accession | P07766 | | Bait Uniprot Identifier | CD3E_HUMAN | | Bait Gene Name | CD3E | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 184-188 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Display technology; Co-IP; Mutation analysis | | Interaction ID | 20915 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17617578 | | Comments | The PxxDY motif of human T-cell surface glycoprotein CD3 epsilon (CD3E) mediates binding to the N-terminal SH3 domain of human Cytoplasmic protein NCK2 |
Record No : 42 |
| Instance ID | 11701 | | Regular Expression | P[KR]RPPxPR | | Motif Instance | PKRPPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1105-1112 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21701 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 43 |
| Instance ID | 11702 | | Regular Expression | P[KR]RPPxPR | | Motif Instance | PKRPPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1105-1112 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21702 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 44 |
| Instance ID | 11703 | | Regular Expression | P[KR]RPPxPR | | Motif Instance | PKRPPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1105-1112 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21703 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 45 |
| Instance ID | 11704 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1065-1070 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21704 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 46 |
| Instance ID | 11705 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1065-1070 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21705 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 47 |
| Instance ID | 11706 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1065-1070 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21706 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 48 |
| Instance ID | 11707 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1065-1070 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21707 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 49 |
| Instance ID | 11708 | | Regular Expression | PxxPxR | | Motif Instance | PAPPQR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1120-1125 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21708 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif II (1120-1125) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 50 |
| Instance ID | 11709 | | Regular Expression | PxxPxR | | Motif Instance | PTIPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1196-1201 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21709 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif III (1196-1201) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 51 |
| Instance ID | 11710 | | Regular Expression | PxxPxR | | Motif Instance | PQPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1284-1289 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21710 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif IV (1284-1289) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 52 |
| Instance ID | 11711 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | P21575 | | Bait Uniprot Identifier | DYN1_RAT | | Bait Gene Name | Dnm1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 833-838 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21711 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9238017 | | Comments | The SH3 domain-binding PxxPxR motif in rat Dynamin-1 that binds the SH3 domain of rat Amphiphysin II |
Record No : 53 |
| Instance ID | 11712 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21712 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 54 |
| Instance ID | 11713 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21713 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 55 |
| Instance ID | 11714 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21714 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 56 |
| Instance ID | 11715 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21715 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 57 |
| Instance ID | 11716 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21716 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 58 |
| Instance ID | 11717 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21717 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 59 |
| Instance ID | 11718 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21718 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Intersectin-1 |
Record No : 60 |
| Instance ID | 11719 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21719 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Intersectin-1 |
Record No : 61 |
| Instance ID | 11720 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21720 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10395825, 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the N-terminal SH3 domain of human adapter protein GRB2 |
Record No : 62 |
| Instance ID | 11721 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21721 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7597091, 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domains of human adapter protein GRB2 |
Record No : 63 |
| Instance ID | 11722 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21722 | | Interacting Domain | SH3 domain | | Disease Association(s) | Centronuclear myopathy | | Inhibitor(s) | Unknown | | Reference(s) | 17676042, 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Amphiphysin |
Record No : 64 |
| Instance ID | 11723 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1151-1156 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay; SPR; ITC | | Interaction ID | 21723 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18778683, 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 2 (1151-1156) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 65 |
| Instance ID | 11724 | | Regular Expression | PxxPxR | | Motif Instance | PAIPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1180-1185 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21724 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 3 (1180-1185) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 66 |
| Instance ID | 11725 | | Regular Expression | PxxPxR | | Motif Instance | PLLPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1212-1217 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21725 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 4 (1212-1217) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 67 |
| Instance ID | 11726 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1290-1295 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21726 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 6 (1290-1295) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 68 |
| Instance ID | 11727 | | Regular Expression | PxxPxR | | Motif Instance | PPLPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1147-1152 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21727 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif I (1147-1152) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 69 |
| Instance ID | 11728 | | Regular Expression | PxxPxR | | Motif Instance | PAIPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1173-1178 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21728 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif II (1173-1178) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 70 |
| Instance ID | 11729 | | Regular Expression | PxxPxR | | Motif Instance | PPPPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1204-1209 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21729 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif III (1204-1209) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 71 |
| Instance ID | 11730 | | Regular Expression | PxxPxR | | Motif Instance | PPVPLR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1217-1222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21730 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif IV (1217-1222) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 72 |
| Instance ID | 11731 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1290-1295 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21731 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif V (1290-1295) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 73 |
| Instance ID | 11732 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | P22681 | | Bait Uniprot Identifier | CBL_HUMAN | | Bait Gene Name | CBL | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 494-499 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Competition binding assay | | Interaction ID | 21732 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7592693, 7791764 | | Comments | The SH3 domain-binding PxxPxR motif in human proto-oncogene c-Cbl that binds the SH3 domains of human adapter protein GRB2 |
Record No : 74 |
| Instance ID | 11733 | | Regular Expression | PxxPxR | | Motif Instance | PPKPPR | | Bait Uniprot Accession | P35831 | | Bait Uniprot Identifier | PTN12_MOUSE | | Bait Gene Name | Ptpn12 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 333-338 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand Overlay Assay | | Interaction ID | 21733 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9135065 | | Comments | The SH3 domain-binding PxxPxR motif 1 (333-338) in murine protein tyrosine phosphatase-PEST (MPTP-PEST) that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 75 |
| Instance ID | 11734 | | Regular Expression | PxxPxR | | Motif Instance | PPLPER | | Bait Uniprot Accession | P35831 | | Bait Uniprot Identifier | PTN12_MOUSE | | Bait Gene Name | Ptpn12 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 675-680 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand Overlay Assay | | Interaction ID | 21734 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9135065 | | Comments | The SH3 domain-binding PxxPxR motif 4 (675-680) in murine protein tyrosine phosphatase-PEST (MPTP-PEST) that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 76 |
| Instance ID | 11735 | | Regular Expression | PxxPxR | | Motif Instance | PPKPSR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 750-755 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21735 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11278488 | | Comments | The SH3 domain-binding PxxPxR motif (750-755) in mouse Focal adhesion kinase 1 that binds the SH3 domain of Tyrosine-protein kinase transforming oncoprotein v-Src, a gene product of Rous sarcoma virus |
Record No : 77 |
| Instance ID | 11736 | | Regular Expression | PxxPxR | | Motif Instance | PKKPPR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 911-916 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21736 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11278488 | | Comments | The SH3 domain-binding PxxPxR motif (911-916) in mouse Focal adhesion kinase 1 that binds the SH3 domain of Tyrosine-protein kinase transforming oncoprotein v-Src, a gene product of Rous sarcoma virus |
Record No : 78 |
| Instance ID | 11737 | | Regular Expression | PxxPxR | | Motif Instance | PPKPSR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 750-755 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21737 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7479864 | | Comments | The SH3 domain-binding PxxPxR motif (750-755) in mouse Focal adhesion kinase 1 that binds the SH3 domain of a v-Crk-associated tyrosine kinase substrate, p130Cas (Breast cancer anti-estrogen resistance protein 1 or Bcar1). This motif, and its interaction it mediates, may be important in the invasion of host cells by Salmonella typhimurium |
Record No : 79 |
| Instance ID | 11738 | | Regular Expression | PxxPxR | | Motif Instance | PKKPPR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 911-916 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21738 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9038154 | | Comments | The SH3 domain-binding PxxPxR motif (911-916) in mouse Focal adhesion kinase 1 that binds the SH3 domain of a v-Crk-associated tyrosine kinase substrate, p130Cas (Breast cancer anti-estrogen resistance protein 1 or Bcar1) |
Record No : 80 |
| Instance ID | 11739 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 588-592 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21739 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8022809, 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domains of human adapter protein GRB2 |
Record No : 81 |
| Instance ID | 11740 | | Regular Expression | xPxxP | | Motif Instance | GPPHP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 653-657 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21740 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin I |
Record No : 82 |
| Instance ID | 11741 | | Regular Expression | xPxxP | | Motif Instance | GPAGP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 594-598 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21741 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 83 |
| Instance ID | 11742 | | Regular Expression | xPxxP | | Motif Instance | RPSGP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 620-624 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21742 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 84 |
| Instance ID | 11743 | | Regular Expression | xPxxP | | Motif Instance | RPTKP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 629-633 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21743 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 85 |
| Instance ID | 11744 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 588-592 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21744 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of chicken c-Src |
Record No : 86 |
| Instance ID | 11745 | | Regular Expression | xPxxP | | Motif Instance | GPGAP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 537-541 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21745 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Phospholipase C-gamma-1 |
Record No : 87 |
| Instance ID | 11746 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 590-594 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21746 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domains of human adapter protein GRB2 |
Record No : 88 |
| Instance ID | 11747 | | Regular Expression | xPxxP | | Motif Instance | GPPHP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 655-659 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21747 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin I |
Record No : 89 |
| Instance ID | 11748 | | Regular Expression | xPxxP | | Motif Instance | GPAGP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 596-600 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21748 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 90 |
| Instance ID | 11749 | | Regular Expression | xPxxP | | Motif Instance | RPSGP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 622-626 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21749 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 91 |
| Instance ID | 11750 | | Regular Expression | xPxxP | | Motif Instance | RPTKP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 631-635 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21750 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 92 |
| Instance ID | 11751 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 590-594 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21751 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of chicken c-Src |
Record No : 93 |
| Instance ID | 11752 | | Regular Expression | xPxxP | | Motif Instance | GPGAP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Bait Organism | Bos taurus (Bovine) | | Sequence Position | 539-543 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21752 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Phospholipase C-gamma-1 |
Record No : 94 |
| Instance ID | 11753 | | Regular Expression | xPxxP | | Motif Instance | RPQVP | | Bait Uniprot Accession | P03407 | | Bait Uniprot Identifier | NEF_HV1A2 | | Bait Gene Name | nef | | Bait Organism | Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) | | Sequence Position | 75-79 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21753 | | Interacting Domain | SH3 domain | | Disease Association(s) | HIV-1 pathogenicity | | Inhibitor(s) | Unknown | | Reference(s) | 7588629 | | Comments | The SH3 domain-binding proline-rich (xPxxP) motif in HIV-1 Nef protein that is necessary for its interaction with human Hck SH3, leading to aberrant activation of HCK, which enhances HIV-1 replication and contributes to HIV-1 pathogenicity |
Record No : 95 |
| Instance ID | 11754 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RRAPAVP | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 783-789 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21754 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155, 9539797 | | Comments | The SH3 domain-binding motif in human Dynamin-1 that binds the SH3 domain of human proto-oncogene c-Src |
Record No : 96 |
| Instance ID | 11755 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RTPPKSP | | Bait Uniprot Accession | P11137 | | Bait Uniprot Identifier | MTAP2_HUMAN | | Bait Gene Name | MAP2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1648-1654 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Thr-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; ELISA | | Interaction ID | 21755 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11546790 | | Comments | The SH3 domain-binding motif in human Microtubule-associated protein 2 [isoform MAP-2c (residues 292-298)] that binds the SH3 domain of human proto-oncogene c-Fyn [Phosphorylation of MAP-2c at this motif by ERK2 abolishes its interaction with Fyn] |
Record No : 97 |
| Instance ID | 11756 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RALPSIP | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 368-374 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21756 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11278488 | | Comments | The SH3 domain-binding motif in mouse Focal adhesion kinase 1 that binds the SH3 domain of Tyrosine-protein kinase transforming oncoprotein v-Src, a gene product of Rous sarcoma virus |
Record No : 98 |
| Instance ID | 11757 | | Regular Expression | [RK]xxPxxP | | Motif Instance | KPLPPLP | | Bait Uniprot Accession | P08018 | | Bait Uniprot Identifier | PBS2_YEAST | | Bait Gene Name | PBS2 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 93-99 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SH3-domain array binding assay; Peptide binding assay | | Interaction ID | 21757 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14668868, 9180081 | | Comments | Interaction of the SH3 domain from the yeast high osmolarity signaling protein SHO1 with a proline-rich motif from the MAP kinase kinase PBS2 |
Record No : 99 |
| Instance ID | 11758 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQTP | | Bait Uniprot Accession | Q02294 | | Bait Uniprot Identifier | CAC1B_RAT | | Bait Gene Name | Cacna1b | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 2185-2191 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21758 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in rat Voltage-gated calcium channel subunit alpha Cav2.2 (Cacna1b) that binds the SH3 domains of chicken RIMS-binding protein 2 (RBP2) |
Record No : 100 |
| Instance ID | 11759 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RLLPPTP | | Bait Uniprot Accession | O73700 | | Bait Uniprot Identifier | CAC1D_CHICK | | Bait Gene Name | CACNA1D | | Bait Organism | Gallus gallus (Chicken) | | Sequence Position | 1938-1944 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H; Competition binding assay | | Interaction ID | 21759 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in chicken Voltage-gated calcium channel subunit alpha Cav1.3 (CACNA1D) that binds the SH3 domains of chicken RIMS-binding protein 2 (RBP2) |
Record No : 101 |
| Instance ID | 11760 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RLLPPTP | | Bait Uniprot Accession | O73700 | | Bait Uniprot Identifier | CAC1D_CHICK | | Bait Gene Name | CACNA1D | | Bait Organism | Gallus gallus (Chicken) | | Sequence Position | 1938-1944 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21760 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in chicken Voltage-gated calcium channel subunit alpha Cav1.3 (CACNA1D) that binds the SH3 domains of human RIMS-binding protein 1 (RBP1) |
Record No : 102 |
| Instance ID | 11761 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RLLPPTP | | Bait Uniprot Accession | O73700 | | Bait Uniprot Identifier | CAC1D_CHICK | | Bait Gene Name | CACNA1D | | Bait Organism | Gallus gallus (Chicken) | | Sequence Position | 1938-1944 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21761 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in chicken Voltage-gated calcium channel subunit alpha Cav1.3 (CACNA1D) that binds the SH3 domains of human RIMS-binding protein 2 (RBP2) |
Record No : 103 |
| Instance ID | 11762 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQVP | | Bait Uniprot Accession | Q86UR5 | | Bait Uniprot Identifier | RIMS1_HUMAN | | Bait Gene Name | RIMS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1269-1275 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21762 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 1 (RIMS1) that binds the SH3 domains of human RIMS-binding protein 1 (RBP1) |
Record No : 104 |
| Instance ID | 11763 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQVP | | Bait Uniprot Accession | Q86UR5 | | Bait Uniprot Identifier | RIMS1_HUMAN | | Bait Gene Name | RIMS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1269-1275 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21763 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 1 (RIMS1) that binds the SH3 domains of human RIMS-binding protein 2 (RBP2) |
Record No : 105 |
| Instance ID | 11764 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQLP | | Bait Uniprot Accession | Q9UQ26 | | Bait Uniprot Identifier | RIMS2_HUMAN | | Bait Gene Name | RIMS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1160-1166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21764 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 2 (RIMS2) that binds the SH3 domains of human RIMS-binding protein 1 (RBP1) |
Record No : 106 |
| Instance ID | 11765 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQLP | | Bait Uniprot Accession | Q9UQ26 | | Bait Uniprot Identifier | RIMS2_HUMAN | | Bait Gene Name | RIMS2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1160-1166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21765 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 2 (RIMS2) that binds the SH3 domains of human RIMS-binding protein 2 (RBP2) |
Record No : 107 |
| Instance ID | 11766 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RPPPPPP | | Bait Uniprot Accession | Q9ULH1 | | Bait Uniprot Identifier | ASAP1_HUMAN | | Bait Gene Name | ASAP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 826-832 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; NMR; Size exclusion chromatography; Dynamic light-scattering analysis | | Interaction ID | 21766 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16636290 | | Comments | The SH3 domain-binding motif in human ASAP1 protein that binds the human cortactin SH3 domain |
Record No : 108 |
| Instance ID | 11767 | | Regular Expression | PPxPxKxK | | Motif Instance | PPVPPKPK | | Bait Uniprot Accession | Q9UPX8 | | Bait Uniprot Identifier | SHAN2_HUMAN | | Bait Gene Name | SHANK2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1165-1172 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; ITC | | Interaction ID | 21767 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19921743 | | Comments | The SH3 domain-binding motif in human SHANK2 that binds the murine cortactin SH3 domain |
Record No : 109 |
| Instance ID | 11768 | | Regular Expression | PPxPxKxK | | Motif Instance | PPLPPKPK | | Bait Uniprot Accession | Q92918 | | Bait Uniprot Identifier | M4K1_HUMAN | | Bait Gene Name | MAP4K1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 395-402 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; ITC | | Interaction ID | 21768 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19921743 | | Comments | The SH3 domain-binding motif in human HPK1 that binds the murine cortactin SH3 domain |
Record No : 110 |
| Instance ID | 11769 | | Regular Expression | PPxPxKxK | | Motif Instance | PPLPPKPK | | Bait Uniprot Accession | Q92918 | | Bait Uniprot Identifier | M4K1_HUMAN | | Bait Gene Name | MAP4K1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 395-402 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | CD; GST-SH3 titration | | Interaction ID | 21769 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21287358, 10233887 | | Comments | The SH3 domain-binding motif in human HPK1 that binds the human HS1 SH3 domain |
Record No : 111 |
| Instance ID | 11770 | | Regular Expression | PxPxPR | | Motif Instance | PKPRPR | | Bait Uniprot Accession | Q13191 | | Bait Uniprot Identifier | CBLB_HUMAN | | Bait Gene Name | CBLB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 906-911 | | Critical Residues | P1; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; ITC; Peptide binding assay; Competition binding assay | | Interaction ID | 21770 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 16228008 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85) |
Record No : 112 |
| Instance ID | 11771 | | Regular Expression | PxPxPR | | Motif Instance | PKPRPR | | Bait Uniprot Accession | Q13191 | | Bait Uniprot Identifier | CBLB_HUMAN | | Bait Gene Name | CBLB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 906-911 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21771 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of CD2-associated protein (CMS/CD2AP) |
Record No : 113 |
| Instance ID | 11772 | | Regular Expression | PxPxPR | | Motif Instance | PKPRPR | | Bait Uniprot Accession | Q13191 | | Bait Uniprot Identifier | CBLB_HUMAN | | Bait Gene Name | CBLB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 906-911 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21772 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 16228008 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of Rho guanine nucleotide exchange factor 7 (Beta-Pix) |
Record No : 114 |
| Instance ID | 11773 | | Regular Expression | PxPxPR | | Motif Instance | PKPFPR | | Bait Uniprot Accession | P22681 | | Bait Uniprot Identifier | CBL_HUMAN | | Bait Gene Name | CBL | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 824-829 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; ITC; Peptide binding assay; Competition binding assay | | Interaction ID | 21773 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 16228008 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85) |
Record No : 115 |
| Instance ID | 11774 | | Regular Expression | PxPxPR | | Motif Instance | PKPFPR | | Bait Uniprot Accession | P22681 | | Bait Uniprot Identifier | CBL_HUMAN | | Bait Gene Name | CBL | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 824-829 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21774 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL specifically recognized by the SH3 domains of CD2-associated protein (CMS/CD2AP) |
Record No : 116 |
| Instance ID | 11775 | | Regular Expression | PxPxPR | | Motif Instance | PLPRPR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 327-332 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21775 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human T-cell surface antigen CD2 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 117 |
| Instance ID | 11776 | | Regular Expression | PxPxPR | | Motif Instance | PLPRPR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 327-332 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21776 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9741631 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human T-cell surface antigen CD2 that may be specifically recognized by the first SH3 Domain of CD2-associated protein (CMS/CD2AP) |
Record No : 118 |
| Instance ID | 11777 | | Regular Expression | PxPxPR | | Motif Instance | PTPAPR | | Bait Uniprot Accession | Q8WUM4 | | Bait Uniprot Identifier | PDC6I_HUMAN | | Bait Gene Name | PDCD6IP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 740-745 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21777 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 10858458 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human Programmed cell death 6-interacting protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 119 |
| Instance ID | 11778 | | Regular Expression | PxPxPR | | Motif Instance | PSPSPR | | Bait Uniprot Accession | Q8TBC3 | | Bait Uniprot Identifier | SHKB1_HUMAN | | Bait Gene Name | SHKBP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 621-626 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21778 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human SH3KBP1-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 120 |
| Instance ID | 11779 | | Regular Expression | PxPxPR | | Motif Instance | PSPSPR | | Bait Uniprot Accession | Q6P7W2 | | Bait Uniprot Identifier | SHKB1_MOUSE | | Bait Gene Name | Shkbp1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 618-623 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21779 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) [618-623] in mouse SETA-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 121 |
| Instance ID | 11780 | | Regular Expression | PxPxPR | | Motif Instance | PTPAPR | | Bait Uniprot Accession | Q6P7W2 | | Bait Uniprot Identifier | SHKB1_MOUSE | | Bait Gene Name | Shkbp1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 678-683 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21780 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) [678-683] in mouse SETA-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 122 |
| Instance ID | 11781 | | Regular Expression | PxPxPR | | Motif Instance | PSPLPR | | Bait Uniprot Accession | Q8WV28 | | Bait Uniprot Identifier | BLNK_HUMAN | | Bait Gene Name | BLNK | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 242-247 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21781 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [242-247] in human B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 123 |
| Instance ID | 11782 | | Regular Expression | PxPxPR | | Motif Instance | PIPLPR | | Bait Uniprot Accession | Q8WV28 | | Bait Uniprot Identifier | BLNK_HUMAN | | Bait Gene Name | BLNK | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 307-312 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21782 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [307-312] in human B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 124 |
| Instance ID | 11783 | | Regular Expression | PxPxPR | | Motif Instance | PSPLPR | | Bait Uniprot Accession | Q9QUN3 | | Bait Uniprot Identifier | BLNK_MOUSE | | Bait Gene Name | Blnk | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 243-248 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21783 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [243-248] in mouse B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 125 |
| Instance ID | 11784 | | Regular Expression | PxPxPR | | Motif Instance | PVPLPR | | Bait Uniprot Accession | Q9QUN3 | | Bait Uniprot Identifier | BLNK_MOUSE | | Bait Gene Name | Blnk | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 308-313 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21784 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [308-313] in mouse B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 126 |
| Instance ID | 11825 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | P40450 | | Bait Uniprot Identifier | BNR1_YEAST | | Bait Gene Name | BNR1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21825 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain ATCC 204508 / S288c) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 127 |
| Instance ID | 11826 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | G2WFZ2 | | Bait Uniprot Identifier | G2WFZ2_YEASK | | Bait Gene Name | K7_BNR1 | | Bait Organism | Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast) | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21826 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 128 |
| Instance ID | 11827 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RTSSL | | Bait Uniprot Accession | G2WAK6 | | Bait Uniprot Identifier | G2WAK6_YEASK | | Bait Gene Name | K7_STE5 | | Bait Organism | Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast) | | Sequence Position | 117-121 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21827 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Ste5p of Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 129 |
| Instance ID | 11828 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | C8ZAV3 | | Bait Uniprot Identifier | C8ZAV3_YEAS8 | | Bait Gene Name | ORF_Name:EC1118_1I12 | | Bait Organism | Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21828 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 130 |
| Instance ID | 11829 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RTSSL | | Bait Uniprot Accession | C8Z519 | | Bait Uniprot Identifier | C8Z519_YEAS8 | | Bait Gene Name | ORF_Name:EC1118_1D0_ | | Bait Organism | Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) | | Sequence Position | 117-121 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21829 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Ste5p of Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 131 |
| Instance ID | 11830 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | C7GUS5 | | Bait Uniprot Identifier | C7GUS5_YEAS2 | | Bait Gene Name | BNR1 | | Bait Organism | Saccharomyces cerevisiae (strain JAY291) (Baker's yeast) | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21830 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain JAY291) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 132 |
| Instance ID | 11831 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RTSSL | | Bait Uniprot Accession | C7GQJ8 | | Bait Uniprot Identifier | C7GQJ8_YEAS2 | | Bait Gene Name | STE5 | | Bait Organism | Saccharomyces cerevisiae (strain JAY291) (Baker's yeast) | | Sequence Position | 117-121 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21831 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Ste5p of Saccharomyces cerevisiae (strain JAY291) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 133 |
| Instance ID | 11832 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | N1P0Y3 | | Bait Uniprot Identifier | N1P0Y3_YEASC | | Bait Gene Name | ORF_Name:CENPK1137D_ | | Bait Organism | Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21832 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain CEN.PK113-7D) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 134 |
| Instance ID | 11833 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RTSSL | | Bait Uniprot Accession | N1P866 | | Bait Uniprot Identifier | N1P866_YEASC | | Bait Gene Name | ORF_Name:CENPK1137D_ | | Bait Organism | Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) | | Sequence Position | 117-121 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21833 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Ste5p of Saccharomyces cerevisiae (strain CEN.PK113-7D) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 135 |
| Instance ID | 11963 | | Regular Expression | PxxxRxxKP | | Motif Instance | PSIDRSTKP | | Bait Uniprot Accession | Q60787 | | Bait Uniprot Identifier | LCP2_MOUSE | | Bait Gene Name | Lcp2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 233-241 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21963 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364, 12620234 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse SLP-76 tyrosine phosphoprotein for binding the Gads SH3 Domain |
Record No : 136 |
| Instance ID | 11964 | | Regular Expression | PxxxRxxKP | | Motif Instance | PQVDRTKKP | | Bait Uniprot Accession | Q80U87 | | Bait Uniprot Identifier | UBP8_MOUSE | | Bait Gene Name | Usp8 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 405-413 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21964 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif 1 (405-413) in mouse Ubiquitin isopeptidase Y for binding the Gads SH3 Domain |
Record No : 137 |
| Instance ID | 11965 | | Regular Expression | PxxxRxxKP | | Motif Instance | PMVNRENKP | | Bait Uniprot Accession | Q80U87 | | Bait Uniprot Identifier | UBP8_MOUSE | | Bait Gene Name | Usp8 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 700-708 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21965 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif 2 (700-708) in mouse Ubiquitin isopeptidase Y for binding the Gads SH3 Domain |
Record No : 138 |
| Instance ID | 11966 | | Regular Expression | PxxxRxxKP | | Motif Instance | PVVDRSLKP | | Bait Uniprot Accession | Q9CQ26 | | Bait Uniprot Identifier | STABP_MOUSE | | Bait Gene Name | Stambp | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 231-239 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21966 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse STAM-binding protein for binding the Gads SH3 Domain |
Record No : 139 |
| Instance ID | 11967 | | Regular Expression | PxxxRxxKP | | Motif Instance | PMVNRSTKP | | Bait Uniprot Accession | Q9QUN3 | | Bait Uniprot Identifier | BLNK_MOUSE | | Bait Gene Name | Blnk | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 204-212 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21967 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse B-cell linker protein for binding the Gads SH3 Domain |
Record No : 140 |
| Instance ID | 11968 | | Regular Expression | PxxxRxxKP | | Motif Instance | PPVDRNLKP | | Bait Uniprot Accession | Q9QYY0 | | Bait Uniprot Identifier | GAB1_MOUSE | | Bait Gene Name | Gab1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 518-526 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21968 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse GRB2-associated-binding protein 1 for binding the Gads SH3 Domain |
Record No : 141 |
| Instance ID | 11969 | | Regular Expression | PxxxRxxKP | | Motif Instance | PPPVNRNLKP | | Bait Uniprot Accession | Q9Z1S8 | | Bait Uniprot Identifier | GAB2_MOUSE | | Bait Gene Name | Gab2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 499-508 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21969 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse GRB2-associated-binding protein 2 for binding the Gads SH3 Domain |
Record No : 142 |
| Instance ID | 11970 | | Regular Expression | PxxxRxxKP | | Motif Instance | SLPPRNIKP | | Bait Uniprot Accession | O35601 | | Bait Uniprot Identifier | FYB_MOUSE | | Bait Gene Name | Fyb | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 406-414 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21970 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse FYN-binding protein/SLAP-130 for binding the Gads SH3 Domain |
Record No : 143 |
| Instance ID | 11981 | | Regular Expression | APKPKVNPF | | Motif Instance | APKPKVNPF | | Bait Uniprot Accession | Q15942 | | Bait Uniprot Identifier | ZYX_HUMAN | | Bait Gene Name | ZYX | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 31-39 | | Critical Residues | P1; P3; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21981 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15004028 | | Comments | Linear binding motif in human Zyxin that is crucial for its interaction with the SH3 Domain of LIM-nebulette (LNEBL) and thus may play an important role in the organization of focal adhesions |
Record No : 144 |
| Instance ID | 11982 | | Regular Expression | APKPKVNPF | | Motif Instance | APKPKVNPF | | Bait Uniprot Accession | Q15942 | | Bait Uniprot Identifier | ZYX_HUMAN | | Bait Gene Name | ZYX | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 31-39 | | Critical Residues | P1; P3; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21982 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15004028 | | Comments | Linear binding motif in human Zyxin that is crucial for its interaction with the SH3 Domain of LASP1 and thus may play an important role in the organization of focal adhesions |
Record No : 145 |
| Instance ID | 12063 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPPPVR | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 553-558 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22063 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The second SH3 domain of Rat actin cytoskeletal adaptor protein Nck1 binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 |
Record No : 146 |
| Instance ID | 12064 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPPPVR | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 553-558 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22064 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The SH3 domain of Rat Sorbin and SH3 domain-containing protein 1 (Sorbs1) or Ponsin binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 |
Record No : 147 |
| Instance ID | 12065 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPPPVR | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 553-558 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22065 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The SH3 domain of Rat Tyrosine-protein kinase Lyn binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 |
Record No : 148 |
| Instance ID | 12145 | | Regular Expression | xxx[PV]xxP | | Motif Instance | GLPPPPP | | Bait Uniprot Accession | O70373 | | Bait Uniprot Identifier | XIRP1_MOUSE | | Bait Gene Name | Xirp1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 32-38 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down(GST tag) | | Interaction ID | 22145 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23296090 | | Comments | The predicted SH3-binding motif in the N-terminal region of mouse Xin actin-binding repeat-containing protein 1 (Xirp1) that interacts with mouse cortactin |
Record No : 149 |
| Instance ID | 12150 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVTPPR | | Bait Uniprot Accession | P62140 | | Bait Uniprot Identifier | PP1B_HUMAN | | Bait Gene Name | PPP1CB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 314-319 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification; SPR | | Interaction ID | 22150 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23088536 | | Comments | The putative SH3-binding PxxPxR motif in the C-terminus of human Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) that binds to the SH3 domain of human Apoptosis-stimulating of p53 protein 1 (ASPP1/PPP1R13B) |
Record No : 150 |
| Instance ID | 12151 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVTPPR | | Bait Uniprot Accession | P62140 | | Bait Uniprot Identifier | PP1B_HUMAN | | Bait Gene Name | PPP1CB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 314-319 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification; SPR; X-ray crystallography | | Interaction ID | 22151 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23088536 | | Comments | The putative SH3-binding PxxPxR motif in the C-terminus of human Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) that binds to the SH3 domain of human Apoptosis-stimulating of p53 protein 2 (ASPP2/TP53BP2) |
Record No : 151 |
| Instance ID | 12152 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVTPPR | | Bait Uniprot Accession | P62140 | | Bait Uniprot Identifier | PP1B_HUMAN | | Bait Gene Name | PPP1CB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 314-319 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification; SPR; X-ray crystallography | | Interaction ID | 22152 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23088536 | | Comments | The putative SH3-binding PxxPxR motif in the C-terminus of human Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) that binds to the SH3 domain of human Inhibitor of ASPP protein (IASPP/PPP1R13L) |
Record No : 152 |
| Instance ID | 12202 | | Regular Expression | PRPxxR | | Motif Instance | PRPAAR | | Bait Uniprot Accession | P16636 | | Bait Uniprot Identifier | LYOX_RAT | | Bait Gene Name | Lox | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 111-116 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Competition binding | | Interaction ID | 22202 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 24167568 | | Comments | Atypical SH3 domain binding motif in rat Protein-lysine 6-oxidase (Lox) that binds the SH3-B domain of rat SH3 domain-containing kinase-binding protein 1 (Sh3kbp1) |
Record No : 153 |
| Instance ID | 12203 | | Regular Expression | PRPxxR | | Motif Instance | PRPTAR | | Bait Uniprot Accession | P28300 | | Bait Uniprot Identifier | LYOX_HUMAN | | Bait Gene Name | LOX | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 117-122 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 22203 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 24167568 | | Comments | Atypical SH3 domain binding motif in human Protein-lysine 6-oxidase (LOX) that binds the SH3-B domain of human SH3 domain-containing kinase-binding protein 1 (SH3KBP1/CIN85) |
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