Query 'Substrate-binding domain(SBD) of SINA/Siah proteins' matched 19 Records
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Record No : 1 |
| Instance ID | 11344 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVRPTVR | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 115-125 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; Peptide binding assay; SPR | | Interaction ID | 21344 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763, 16615911 | | Comments | Peptide motif that mediates the interaction of phyl with Mouse Siah1a |
Record No : 2 |
| Instance ID | 11345 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVRPTVR | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 115-125 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; Peptide binding assay; SPR | | Interaction ID | 21345 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Peptide motif that mediates the interaction of phyl with Mouse Siah2 |
Record No : 3 |
| Instance ID | 11346 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVRPTVR | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 115-125 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Peptide binding assay; SPR | | Interaction ID | 21346 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Peptide motif that mediates the interaction of phyl with Drosophila SINA |
Record No : 4 |
| Instance ID | 11347 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVIPARR | | Bait Uniprot Accession | Q9QXS1 | | Bait Uniprot Identifier | PLEC_MOUSE | | Bait Gene Name | Plec | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 102-112 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Peptide binding assay; SPR | | Interaction ID | 21347 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Degradation signal or “degron” motif in mouse plectin-1 which mediates binding to the Siah1a ubiquitin ligase |
Record No : 5 |
| Instance ID | 11348 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVIPARR | | Bait Uniprot Accession | Q9QXS1 | | Bait Uniprot Identifier | PLEC_MOUSE | | Bait Gene Name | Plec | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 102-112 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Peptide binding assay; SPR | | Interaction ID | 21348 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Degradation signal or “degron” motif in mouse plectin-1 which mediates binding to the Siah2 ubiquitin ligase |
Record No : 6 |
| Instance ID | 11349 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVIPARR | | Bait Uniprot Accession | Q9QXS1 | | Bait Uniprot Identifier | PLEC_MOUSE | | Bait Gene Name | Plec | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 102-112 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Peptide binding assay; SPR | | Interaction ID | 21349 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Peptide motif that mediates its interaction of mouse plectin-1 with Drosophila SINA |
Record No : 7 |
| Instance ID | 11350 | | Regular Expression | PxAxVxP | | Motif Instance | PCAAVSP | | Bait Uniprot Accession | Q13118 | | Bait Uniprot Identifier | KLF10_HUMAN | | Bait Gene Name | KLF10 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 201-207 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21350 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12072443, 12626763 | | Comments | Peptide motif that mediates the interaction of the human TIEG1 protein with SIAH1 |
Record No : 8 |
| Instance ID | 11351 | | Regular Expression | PxAxVxP | | Motif Instance | PCAAVSP | | Bait Uniprot Accession | Q13118 | | Bait Uniprot Identifier | KLF10_HUMAN | | Bait Gene Name | KLF10 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 201-207 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21351 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12072443, 12626763 | | Comments | Peptide motif that mediates the interaction of the human TIEG1 protein with SIAH2 |
Record No : 9 |
| Instance ID | 11352 | | Regular Expression | PxAxVxP | | Motif Instance | PTACVRP | | Bait Uniprot Accession | P43146 | | Bait Uniprot Identifier | DCC_HUMAN | | Bait Gene Name | DCC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1332-1338 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21352 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9334332, 12626763 | | Comments | Peptide motif that mediates the interaction of the DCC cytoplasmic domain with SIAH1 |
Record No : 10 |
| Instance ID | 11353 | | Regular Expression | PxAxVxP | | Motif Instance | PTACVRP | | Bait Uniprot Accession | P43146 | | Bait Uniprot Identifier | DCC_HUMAN | | Bait Gene Name | DCC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1332-1338 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21353 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9334332, 12626763 | | Comments | Peptide motif that mediates the interaction of the DCC cytoplasmic domain with SIAH2 |
Record No : 11 |
| Instance ID | 11354 | | Regular Expression | PxAxVxP | | Motif Instance | PAAVVAP | | Bait Uniprot Accession | Q9HB71 | | Bait Uniprot Identifier | CYBP_HUMAN | | Bait Gene Name | CACYBP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 60-66 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21354 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11389839, 12626763 | | Comments | Peptide motif that mediates the interaction of SIP (a novel Siah-interacting protein) with SIAH1 |
Record No : 12 |
| Instance ID | 11355 | | Regular Expression | PxAxVxP | | Motif Instance | PAAVVAP | | Bait Uniprot Accession | Q9HB71 | | Bait Uniprot Identifier | CYBP_HUMAN | | Bait Gene Name | CACYBP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 60-66 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21355 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11389839, 12626763 | | Comments | Peptide motif that mediates the interaction of SIP (a novel Siah-interacting protein) with SIAH2 |
Record No : 13 |
| Instance ID | 11356 | | Regular Expression | PxAxVxP | | Motif Instance | PTAVVLP | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 47-53 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21356 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483517, 11483518, 12626763 | | Comments | Peptide motif that mediates the interaction of OBF-1 with SIAH1 |
Record No : 14 |
| Instance ID | 11357 | | Regular Expression | PxAxVxP | | Motif Instance | PTAVVLP | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 47-53 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21357 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483517, 11483518, 12626763 | | Comments | Peptide motif that mediates the interaction of OBF-1 with SIAH2 |
Record No : 15 |
| Instance ID | 11358 | | Regular Expression | PxAxVxP | | Motif Instance | PTATVRP | | Bait Uniprot Accession | Q07912 | | Bait Uniprot Identifier | ACK1_HUMAN | | Bait Gene Name | TNK2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 905-911 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21358 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23208506 | | Comments | SIAH1-binding motif located in the far C-terminus of ACK1 |
Record No : 16 |
| Instance ID | 11359 | | Regular Expression | PxAxVxP | | Motif Instance | PTATVRP | | Bait Uniprot Accession | Q07912 | | Bait Uniprot Identifier | ACK1_HUMAN | | Bait Gene Name | TNK2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 905-911 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21359 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23208506 | | Comments | SIAH2-binding motif located in the far C-terminus of ACK1 |
Record No : 17 |
| Instance ID | 11360 | | Regular Expression | PVGVVVP | | Motif Instance | PVGVVVP | | Bait Uniprot Accession | O75525 | | Bait Uniprot Identifier | KHDR3_HUMAN | | Bait Gene Name | KHDRBS3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 213-219 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21360 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15163637, 23208506 | | Comments | SIAH1-binding region in human T-STAR responsible for its proteasomal degradation |
Record No : 18 |
| Instance ID | 11361 | | Regular Expression | PVGVVVP | | Motif Instance | PVGVVVP | | Bait Uniprot Accession | O75525 | | Bait Uniprot Identifier | KHDR3_HUMAN | | Bait Gene Name | KHDRBS3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 213-219 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21361 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15163637, 23208506 | | Comments | SIAH2-binding region in human T-STAR |
Record No : 19 |
| Instance ID | 11362 | | Regular Expression | AVVMP | | Motif Instance | AVVMP | | Bait Uniprot Accession | Q14807 | | Bait Uniprot Identifier | KIF22_HUMAN | | Bait Gene Name | KIF22 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 529-533 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21362 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11146551, 12626763 | | Comments | SIAH-1 binding region involved in the degradation of Kid via the ubiquitin-proteasome pathway |
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