Query   'Sufu N-terminal binding domain'  matched   3 Records

Record No : 1

Instance ID12210
Regular Expression[SV][CY]GH[LIF][LAST][GAIV]x
Motif InstanceSYGHLSIG
Bait Uniprot AccessionP08151
Bait Uniprot IdentifierGLI1_HUMAN
Bait Gene NameGLI1
Bait OrganismHomo sapiens (Human)
Sequence Position120-127
Critical ResiduesP3; P4; P5
Motif PTM(s)Unknown
Secondary StructureBeta strand
Experimental Method(s)Mutational analysis; X-ray crystallography; ITC; Pull down; Co-IP; Far Western assay; Microscale thermophoresis
Interaction ID22210
Interacting DomainSufu N-terminal binding domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12426310, 24217340, 24311597
CommentsThe highly conserved ‘SYGHLS’ motif of human Zinc finger protein GLI1 that is critical for its association with human SUFU (Suppressor of fused homolog)

Record No : 2

Instance ID12211
Regular Expression[SV][CY]GH[LIF][LAST][GAIV]x
Motif InstanceSYGHLSAS
Bait Uniprot AccessionP10071
Bait Uniprot IdentifierGLI3_HUMAN
Bait Gene NameGLI3
Bait OrganismHomo sapiens (Human)
Sequence Position333-340
Critical ResiduesP3; P4; P5
Motif PTM(s)Unknown
Secondary StructureBeta strand
Experimental Method(s)X-ray crystallography; Far Western assay
Interaction ID22211
Interacting DomainSufu N-terminal binding domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12426310, 24311597
CommentsThe highly conserved ‘SYGHLS’ motif of human Transcriptional activator GLI3 that is critical for its association with human SUFU (Suppressor of fused homolog)

Record No : 3

Instance ID12212
Regular Expression[SV][CY]GH[LIF][LAST][GAIV]x
Motif InstanceSYGHLSAG
Bait Uniprot AccessionQ0VGT2
Bait Uniprot IdentifierGLI2_MOUSE
Bait Gene NameGli2
Bait OrganismMus musculus (Mouse)
Sequence Position268-275
Critical ResiduesP3; P4; P5
Motif PTM(s)Unknown
Secondary StructureBeta strand
Experimental Method(s)Mutational analysis; X-ray crystallography; Co-IP
Interaction ID22212
Interacting DomainSufu N-terminal binding domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)24217340
CommentsThe highly conserved ‘SYGHLS’ motif of mouse Zinc finger protein Gli2 that is critical for its association with human SUFU (Suppressor of fused homolog)


© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)