Query 'TKB Domain' matched 11 Records
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Record No : 1 |
| Instance ID | 11855 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | NLYSSLP | | Bait Uniprot Accession | P07174 | | Bait Uniprot Identifier | TNR16_RAT | | Bait Gene Name | Ngfr | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 335-341 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21855 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 15337528 | | Comments | Consensus sequence for phosphotyrosine recognition by the c-Cbl TKB domain in rat p75 neurotrophin receptor, suggesting a c-Cbl-dependent ubiquitination of p75NTR involved in the regulation of p75NTR signalling |
Record No : 2 |
| Instance ID | 11856 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | DGYTPEP | | Bait Uniprot Accession | P43403 | | Bait Uniprot Identifier | ZAP70_HUMAN | | Bait Gene Name | ZAP70 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 290-296 | | Critical Residues | P1; P3; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis | | Interaction ID | 21856 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9407100, 15737992, 10078535 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in Tyrosine-protein kinase ZAP-70 that has been demonstrated to be an important in vivo negative regulatory site for ZAP-70 by Cbl |
Record No : 3 |
| Instance ID | 11857 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | QRYSSDP | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1067-1073 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21857 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 10635327 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Epidermal growth factor receptor, which indicates that Cbl adaptor proteins directly control downregulation of the receptor for the epidermal growth factor (EGFR) by recruiting ubiquitin-activating and -conjugating enzymes |
Record No : 4 |
| Instance ID | 11858 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | NEYTEGP | | Bait Uniprot Accession | O43597 | | Bait Uniprot Identifier | SPY2_HUMAN | | Bait Gene Name | SPRY2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 53-59 | | Critical Residues | P1; P3; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21858 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12815057 | | Comments | Consensus sequence for phosphotyrosine recognition by the c-Cbl TKB domain in human protein Sprouty homolog 2 and this high affinity interaction is critical for its physiological function in a signal-specific context |
Record No : 5 |
| Instance ID | 11859 | | Regular Expression | NxY[STEQ] | | Motif Instance | NEYT | | Bait Uniprot Accession | P12931 | | Bait Uniprot Identifier | SRC_HUMAN | | Bait Gene Name | SRC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 417-420 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21859 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 11448952 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Proto-oncogene tyrosine-protein kinase Src where c-Cbl acts as a ubiquitin ligase thus down-regulating Src |
Record No : 6 |
| Instance ID | 11860 | | Regular Expression | NxY[STEQ] | | Motif Instance | NEYT | | Bait Uniprot Accession | P06241 | | Bait Uniprot Identifier | FYN_HUMAN | | Bait Gene Name | FYN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 418-421 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21860 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 10629042 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Tyrosine-protein kinase Fyn that implicate Cbl as a component in the negative regulation of Fyn |
Record No : 7 |
| Instance ID | 11861 | | Regular Expression | NxY[STEQ] | | Motif Instance | NPYE | | Bait Uniprot Accession | P43405 | | Bait Uniprot Identifier | KSYK_HUMAN | | Bait Gene Name | SYK | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 321-324 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21861 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 9857068 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Tyrosine-protein kinase SYK that plays a critical role in the recruitment of Cbl to Syk and in Cbl-mediated negative regulation of Syk |
Record No : 8 |
| Instance ID | 11862 | | Regular Expression | NxY[STEQ] | | Motif Instance | NNYQ | | Bait Uniprot Accession | P07333 | | Bait Uniprot Identifier | CSF1R_HUMAN | | Bait Gene Name | CSF1R | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 967-970 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21862 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 11847211 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Macrophage colony-stimulating factor 1 receptor (CSF1R) that promotes Cbl-dependent ubiquitination of CSF1R |
Record No : 9 |
| Instance ID | 11863 | | Regular Expression | RA[VI]xNQY[ST] | | Motif Instance | RAVENQYS | | Bait Uniprot Accession | O14492 | | Bait Uniprot Identifier | SH2B2_HUMAN | | Bait Gene Name | SH2B2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 623-630 | | Critical Residues | P1; P2; P3; P5; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; ITC | | Interaction ID | 21863 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992 | | Comments | Novel Cbl phosphotyrosine recognition motif in SH2B adapter protein 2 (APS) that serves as a binding site for the Cbl TKB domain and allows Cbl ito be recruited to and phosphorylated by the insulin receptor in adipose cells through the adapter protein APS |
Record No : 10 |
| Instance ID | 11997 | | Regular Expression | DYR | | Motif Instance | DYR | | Bait Uniprot Accession | P08581 | | Bait Uniprot Identifier | MET_HUMAN | | Bait Gene Name | MET | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1002-1004 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; Co-IP; Far Western blotting; Competition binding | | Interaction ID | 21997 | | Interacting Domain | TKB Domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15123609 | | Comments | The ubiquitination of human Proto-oncogene c-Met by human Proto-oncogene c-Cbl requires the direct interaction of the c-Cbl Tyrosine Kinase binding (TKB) domain with conserved DpY(1003)R motif in the Met juxtamembrane domain leading to suppression of oncogenic activation |
Record No : 11 |
| Instance ID | 11998 | | Regular Expression | DYR | | Motif Instance | DYR | | Bait Uniprot Accession | P08581 | | Bait Uniprot Identifier | MET_HUMAN | | Bait Gene Name | MET | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1002-1004 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; Pull down(GST tag) | | Interaction ID | 21998 | | Interacting Domain | TKB Domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15123609 | | Comments | The TKB domain of human E3 ubiquitin-protein ligase CBL-B binds to human Hepatocyte growth factor receptor (MET) via the conserved DpY(1003)R motif in the MET juxtamembrane domain |
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