Query   'Tetratricopeptide repeat (TPR) domain'  matched   2 Records

Record No : 1

Instance ID11013
Regular ExpressionEEVD
Motif InstanceEEVD
Bait Uniprot AccessionP07900
Bait Uniprot IdentifierHS90A_HUMAN
Bait Gene NameHSP90AA1
Bait OrganismHomo sapiens (Human)
Sequence Position729-732
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)NMR; X-ray crystallography; Alanine scanning; Mutation analysis
Interaction ID21013
Interacting DomainTetratricopeptide repeat (TPR) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16531226, 10786835, 11877417, 10567422
CommentsThe C-terminal sequence EEVD in human Heat shock protein HSP 90-alpha (HSP90AA1) that binds to the TPR (tetratricopeptide repeat) domain of human Stress-induced-phosphoprotein 1 (STIP1)/ Hsc70/Hsp90-organizing protein (Hop)

Record No : 2

Instance ID11990
Regular ExpressionEEVD
Motif InstanceEEVD
Bait Uniprot AccessionP11142
Bait Uniprot IdentifierHSP7C_HUMAN
Bait Gene NameHSPA8
Bait OrganismHomo sapiens (Human)
Sequence Position643-646
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; ITC; SPR; Competition binding
Interaction ID21990
Interacting DomainTetratricopeptide repeat (TPR) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11877417, 19586912
CommentsThe C-terminal sequence EEVD in human Heat shock cognate 71 kDa protein (HSPA8/HSC70) that binds to the TPR2A domain of human Stress-induced-phosphoprotein 1 (STIP1)/ Hsc70/Hsp90-organizing protein (Hop)


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)