Query 'V-domain' matched 8 Records
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Record No : 1 |
| Instance ID | 10511 | | Regular Expression | [LM]YPxxx[LI][^P][^P][LI] | | Motif Instance | LYPLTSLRSL | | Bait Uniprot Accession | P03347 | | Bait Uniprot Identifier | GAG_HV1B1 | | Bait Gene Name | gag | | Bait Organism | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | | Sequence Position | 495-504 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; SPR; Y2H; Pull down; ITC; X-ray crystallography | | Interaction ID | 20511 | | Interacting Domain | V-domain | | Disease Association(s) | Human immunodeficiency virus (HIV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 17350572, 14519844, 14505569, 17277784, 18066081 | | Comments | Efficient budding of retroviruses such as HIV-1 requires short peptide motifs, known as late domains, in the viral Gag protein, that recruits human ALIX (AIP1/PDCD6IP) |
Record No : 2 |
| Instance ID | 10512 | | Regular Expression | [LM]YPxxx[LI][^P][^P][LI] | | Motif Instance | LYPLTSLRSL | | Bait Uniprot Accession | P04591 | | Bait Uniprot Identifier | GAG_HV1H2 | | Bait Gene Name | gag | | Bait Organism | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | | Sequence Position | 483-492 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | SPR; ITC; Mutation analysis; X-ray crystallography | | Interaction ID | 20512 | | Interacting Domain | V-domain | | Disease Association(s) | Human immunodeficiency virus (HIV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 18066081 | | Comments | Efficient budding of retroviruses such as HIV-1 requires short peptide motifs, known as late domains, in the viral Gag protein, that recruits human ALIX (AIP1/PDCD6IP) |
Record No : 3 |
| Instance ID | 10513 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | MYPRL | | Bait Uniprot Accession | Q00202 | | Bait Uniprot Identifier | PACC_EMENI | | Bait Gene Name | pacC | | Bait Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) | | Sequence Position | 454-458 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag) | | Interaction ID | 20513 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12588984 | | Comments | The regulation of gene expression by ambient pH in Aspergillus nidulans involves the zinc finger transcription factor pacC/RIM101 that interacts with pH-response regulator protein palA/RIM20, a component of the fungal ambient pH signal transduction pathway, through its LYPxL motif (454-458) |
Record No : 4 |
| Instance ID | 10514 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | LYPSL | | Bait Uniprot Accession | P03322 | | Bait Uniprot Identifier | GAG_RSVP | | Bait Gene Name | gag-pro | | Bait Organism | Rous sarcoma virus (strain Prague C) (RSV-PrC) | | Sequence Position | 180-184 | | Critical Residues | P1; P2; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20514 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20392845 | | Comments | The LYPXL motif in Gag-Pro polyprotein of Rous sarcoma virus (RSV) that mediates budding through an interaction with the human ESCRT adaptor protein ALIX (AIP1/PDCD6IP) |
Record No : 5 |
| Instance ID | 10515 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | LYPDL | | Bait Uniprot Accession | P69732 | | Bait Uniprot Identifier | GAG_EIAVY | | Bait Gene Name | gag | | Bait Organism | Equine infectious anemia virus (strain Wyoming) (EIAV) | | Sequence Position | 457-461 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; SPR; Y2H; Pull down | | Interaction ID | 20515 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18066081, 17350572, 17158451, 14519844, 14505569 | | Comments | The LYPXL motif in Gag polyprotein of Equine infectious anemia virus (EIAV) that binds the human ESCRT adaptor protein ALIX (AIP1/PDCD6IP) |
Record No : 6 |
| Instance ID | 10516 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | LYPAL | | Bait Uniprot Accession | P03355 | | Bait Uniprot Identifier | POL_MLVMS | | Bait Gene Name | gag-pol | | Bait Organism | Moloney murine leukemia virus (isolate Shinnick) (MoMLV) | | Sequence Position | 130-134 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20516 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15908698 | | Comments | The LYPxL motif in Moloney murine leukemia virus Gag that binds to a hydrophobic groove in the central V-domain of Mouse Alix (Pdcd6ip/Aip1) |
Record No : 7 |
| Instance ID | 10517 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | MYPTL | | Bait Uniprot Accession | Q00202 | | Bait Uniprot Identifier | PACC_EMENI | | Bait Gene Name | pacC | | Bait Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) | | Sequence Position | 661-665 | | Critical Residues | P2; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag) | | Interaction ID | 20517 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12588984 | | Comments | The regulation of gene expression by ambient pH in Aspergillus nidulans involves the zinc finger transcription factor pacC/RIM101 that interacts with pH-response regulator protein palA/RIM20, a component of the fungal ambient pH signal transduction pathway, through its LYPxL motif (661-665) |
Record No : 8 |
| Instance ID | 10518 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | MYPTL | | Bait Uniprot Accession | Q00202 | | Bait Uniprot Identifier | PACC_EMENI | | Bait Gene Name | pacC | | Bait Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) | | Sequence Position | 661-665 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20518 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12588984 | | Comments | The LYPxL motif (661-665) of Aspergillus nidulans pH-response transcription factor pacC/RIM101 that interacts with human ALIX (AIP1/PDCD6IP) |
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