Query 'WW domain' matched 156 Records
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Record No : 1 |
| Instance ID | 11049 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P97764 | | Bait Uniprot Identifier | WBP1_MOUSE | | Bait Gene Name | Wbp1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 173-176 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21049 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7644498 | | Comments | The PY motif of mouse WW domain-binding protein 1 (Wbp1) binds with relatively high affinity and specificity to the WW domain of mouse Yes-associated protein (Yap1/Yap65) |
Record No : 2 |
| Instance ID | 11050 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q14118 | | Bait Uniprot Identifier | DAG1_HUMAN | | Bait Gene Name | DAG1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 889-992 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21050 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10932245 | | Comments | The C-terminal region of human Dystrophin (DMD) binds the cytoplasmic tail of human Dystroglycan (DAG1) through the interaction of its WW domain with a proline-rich motif in the tail of DAG1 |
Record No : 3 |
| Instance ID | 11051 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Bait Organism | Bluetongue virus 10 (isolate USA) (BTV 10) | | Sequence Position | 36-39 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Mutation analysis | | Interaction ID | 21051 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | Non-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase NEDD4 |
Record No : 4 |
| Instance ID | 11052 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P13285 | | Bait Uniprot Identifier | LMP2_EBVB9 | | Bait Gene Name | LMP2 | | Bait Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) | | Sequence Position | 57-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | ITC; NMR | | Interaction ID | 21052 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17437719 | | Comments | The PY motif of Epstein-Barr virus Latent membrane protein 2 (LMP2) binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch |
Record No : 5 |
| Instance ID | 11053 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P13285 | | Bait Uniprot Identifier | LMP2_EBVB9 | | Bait Gene Name | LMP2 | | Bait Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) | | Sequence Position | 98-101 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 21053 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11046148 | | Comments | The PY motif of Epstein-Barr virus Latent membrane protein 2 (LMP2) binds to the WW domain of human E3 ubiquitin-protein ligase ITCH/AIP4 and may thereby regulate B-cell receptor (BCR) signaling |
Record No : 6 |
| Instance ID | 11054 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | P03276 | | Bait Uniprot Identifier | CAPSP_ADE02 | | Bait Gene Name | ORF_Name:L2 | | Bait Organism | Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) | | Sequence Position | 12-15 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Co-IP; SPR; Mutation analysis | | Interaction ID | 21054 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12450395 | | Comments | The PY motif of the Penton base protein of Human adenovirus 2 that binds to the WW domain of human NEDD4-like E3 ubiquitin-protein ligase WWP1 |
Record No : 7 |
| Instance ID | 11055 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P28282 | | Bait Uniprot Identifier | UL56_HHV2H | | Bait Gene Name | UL56 | | Bait Organism | Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) | | Sequence Position | 23-26 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H; Mutation analysis | | Interaction ID | 21055 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18353951 | | Comments | The PY motif (23-26) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells |
Record No : 8 |
| Instance ID | 11056 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P35260 | | Bait Uniprot Identifier | VP40_MABVM | | Bait Gene Name | VP40 | | Bait Organism | Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) | | Sequence Position | 16-19 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Confocal microscopy; Pull down; Mutation analysis | | Interaction ID | 21056 | | Interacting Domain | WW domain | | Disease Association(s) | Marburg virus disease (MVD) | | Inhibitor(s) | Unknown | | Reference(s) | 19812267 | | Comments | The PY motif of the VP40 matrix protein of Marburg virus (MARV) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 |
Record No : 9 |
| Instance ID | 11057 | | Regular Expression | PPxY | | Motif Instance | PPEY | | Bait Uniprot Accession | Q05128 | | Bait Uniprot Identifier | VP40_EBOZM | | Bait Gene Name | VP40 | | Bait Organism | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) | | Sequence Position | 10-13 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Western blot; Mutation analysis | | Interaction ID | 21057 | | Interacting Domain | WW domain | | Disease Association(s) | Ebola virus infection | | Inhibitor(s) | Unknown | | Reference(s) | 11095724 | | Comments | The PPxY motif within the Membrane-associated Matrix protein VP40 of Ebola virus interacts physically and functionally with mouse E3 ubiquitin-protein ligase Nedd4 |
Record No : 10 |
| Instance ID | 11058 | | Regular Expression | PPxY | | Motif Instance | PPAY | | Bait Uniprot Accession | Q15797 | | Bait Uniprot Identifier | SMAD1_HUMAN | | Bait Gene Name | SMAD1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 224-227 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21058 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21685363 | | Comments | The PY motif of human SMAD1 that binds to the WW domain of human E3 ubiquitin-protein ligase SMURF1 |
Record No : 11 |
| Instance ID | 11059 | | Regular Expression | PPxY | | Motif Instance | PPAY | | Bait Uniprot Accession | Q15303 | | Bait Uniprot Identifier | ERBB4_HUMAN | | Bait Gene Name | ERBB4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1053-1056 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Confocal microscopy; Pull down; Mutation analysis | | Interaction ID | 21059 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18334649 | | Comments | The PPXY motif within the CYT-1 isoforms of human Receptor tyrosine-protein kinase ERBB4 provides a binding site for human WW domain-containing E3 ubiquitin-protein ligase ITCH and is necessary both for ubiquitination and endocytosis of CYT-1 isoforms |
Record No : 12 |
| Instance ID | 11060 | | Regular Expression | PPxY | | Motif Instance | PPKY | | Bait Uniprot Accession | P51170 | | Bait Uniprot Identifier | SCNNG_HUMAN | | Bait Gene Name | SCNN1G | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 624-627 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot | | Interaction ID | 21060 | | Interacting Domain | WW domain | | Disease Association(s) | Liddle's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 17502380 | | Comments | The PPXY motif of human Epithelial Na(+) channel subunit gamma (SCNN1G) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2 |
Record No : 13 |
| Instance ID | 11061 | | Regular Expression | PPxY | | Motif Instance | PPNY | | Bait Uniprot Accession | P51168 | | Bait Uniprot Identifier | SCNNB_HUMAN | | Bait Gene Name | SCNN1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 617-620 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot | | Interaction ID | 21061 | | Interacting Domain | WW domain | | Disease Association(s) | Liddle's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 17502380 | | Comments | The PPXY motif of human Epithelial Na(+) channel subunit beta (SCNN1B) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2 |
Record No : 14 |
| Instance ID | 11062 | | Regular Expression | PPxY | | Motif Instance | PPAY | | Bait Uniprot Accession | P37088 | | Bait Uniprot Identifier | SCNNA_HUMAN | | Bait Gene Name | SCNN1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 641-644 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot | | Interaction ID | 21062 | | Interacting Domain | WW domain | | Disease Association(s) | Liddle's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 17502380 | | Comments | The PPXY motif of human Epithelial Na(+) channel subunit alpha (SCNN1A) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2 |
Record No : 15 |
| Instance ID | 11063 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 484-487 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Co-IP; Pull down(GST tag); Mutation analysis | | Interaction ID | 21063 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15678106 | | Comments | The human WW domain-containing E3 ubiquitin-protein ligase ITCH selectively binds and ubiquitinates the human Tumor protein TP73 via the PPXY motif of TP73, which results in the rapid proteasome-dependent degradation of TP73 |
Record No : 16 |
| Instance ID | 11064 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 484-487 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag); Pull down(His tag); Mutation analysis | | Interaction ID | 21064 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11278685 | | Comments | The PPXY motif of human Tumor protein TP73 provides a binding site for human transcription coactivator Yes-associated protein (YAP1/YAP65) |
Record No : 17 |
| Instance ID | 11065 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P03345 | | Bait Uniprot Identifier | GAG_HTL1A | | Bait Gene Name | gag | | Bait Organism | Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) | | Sequence Position | 118-121 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21065 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14998512 | | Comments | The PPXY motif of the Gag polyprotein of human T-cell leukemia virus type 1 (HTLV-1) that binds to the WW domain of Human E3 ubiquitin-protein ligase NEDD4 |
Record No : 18 |
| Instance ID | 11066 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P28282 | | Bait Uniprot Identifier | UL56_HHV2H | | Bait Gene Name | UL56 | | Bait Organism | Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) | | Sequence Position | 49-52 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H | | Interaction ID | 21066 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18353951 | | Comments | The PY motif (49-52) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells |
Record No : 19 |
| Instance ID | 11067 | | Regular Expression | PPxY | | Motif Instance | PPEY | | Bait Uniprot Accession | Q4VCS5 | | Bait Uniprot Identifier | AMOT_HUMAN | | Bait Gene Name | AMOT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 239-242 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 21067 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21205866 | | Comments | The PPXY motif of human Angiomotin (AMOT), a component of the Hippo tumor suppressor pathway, that binds to the WW domain of human transcription coactivator Yes-associated protein (YAP1/YAP65), thereby inhibiting YAP oncoprotein through phosphorylation-induced cytoplasmic retention and degradation |
Record No : 20 |
| Instance ID | 11068 | | Regular Expression | PPxY | | Motif Instance | PPVY | | Bait Uniprot Accession | P05627 | | Bait Uniprot Identifier | JUN_MOUSE | | Bait Gene Name | Jun | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 167-170 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Co-IP; Colocalization; Mutation analysis | | Interaction ID | 21068 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16901904, 15469925, 11828324 | | Comments | The PPXY motif of mouse Proto-oncogene c-Jun that binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch which targets Jun for lysosomal degradation |
Record No : 21 |
| Instance ID | 11069 | | Regular Expression | PPxY | | Motif Instance | PPVY | | Bait Uniprot Accession | P09450 | | Bait Uniprot Identifier | JUNB_MOUSE | | Bait Gene Name | Junb | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 176-179 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Co-IP; Pull down; Mutation analysis | | Interaction ID | 21069 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11828324 | | Comments | The PPXY motif of mouse Transcription factor Jun-b that binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch and induces ubiquitination of Jun-b |
Record No : 22 |
| Instance ID | 11070 | | Regular Expression | xxx([ST])Px | | Motif Instance | KATSPK | | Bait Uniprot Accession | Q8BT07 | | Bait Uniprot Identifier | CEP55_MOUSE | | Bait Gene Name | Cep55 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 420-425 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning; Phosphatase assay | | Interaction ID | 21070 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19638580 | | Comments | The mouse peptidyl-prolyl isomerase Pin1 regulates the final stages of cytokinesis by binding to the Ser-423-Pro motif of mouse Centrosomal protein of 55 kDa (Cep55), an essential component of the midbody ring |
Record No : 23 |
| Instance ID | 11071 | | Regular Expression | xxx([ST])Px | | Motif Instance | CVLSPV | | Bait Uniprot Accession | Q9Y6H5 | | Bait Uniprot Identifier | SNCAP_HUMAN | | Bait Gene Name | SNCAIP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 208-213 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down | | Interaction ID | 21071 | | Interacting Domain | WW domain | | Disease Association(s) | Parkinson disease | | Inhibitor(s) | Unknown | | Reference(s) | 16365047 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-211-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions |
Record No : 24 |
| Instance ID | 11072 | | Regular Expression | xxx([ST])Px | | Motif Instance | EAASPR | | Bait Uniprot Accession | Q80Z64 | | Bait Uniprot Identifier | NANOG_MOUSE | | Bait Gene Name | Nanog | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 49-54 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21072 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20622153 | | Comments | Phosphorylation of Ser-52 promotes the interaction between the mouse Homeobox protein Nanog and the mouse Peptidyl-prolyl cis-trans isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination |
Record No : 25 |
| Instance ID | 11073 | | Regular Expression | xxx([ST])Px | | Motif Instance | LQGSPD | | Bait Uniprot Accession | Q80Z64 | | Bait Uniprot Identifier | NANOG_MOUSE | | Bait Gene Name | Nanog | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 62-67 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21073 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20622153 | | Comments | Phosphorylation of Ser-65 promotes the interaction between the mouse Homeobox protein Nanog and the mouse Peptidyl-prolyl cis-trans isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination |
Record No : 26 |
| Instance ID | 11074 | | Regular Expression | xxx([ST])Px | | Motif Instance | SDSSPS | | Bait Uniprot Accession | P35210 | | Bait Uniprot Identifier | SPT23_YEAST | | Bait Gene Name | SPT23 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 651-656 | | Critical Residues | P4; P5 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Alanine scanning | | Interaction ID | 21074 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19597489 | | Comments | The yeast peptidyl-prolyl cis/trans isomerase Pin1 (Ess1) is essential for viability because it controls the NF-kappaB-related Spt23 transcription factor involved in unsaturated fatty-acid synthesis via an interaction with phosphorylated Ser-654 of Spt23 |
Record No : 27 |
| Instance ID | 11075 | | Regular Expression | xxx([ST])Px | | Motif Instance | NVLSPL | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 30-35 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 21075 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12388558 | | Comments | DNA damage enhances the interaction between human Peptidyl-prolyl cis-trans isomerase PIN1 and Cellular tumor antigen TP53 mediated by the WW domain in PIN1 and Ser(33)-Pro motif in TP53, whereby PIN1 regulates the stability of TP53 and its transcriptional activity towards the p21 promoter |
Record No : 28 |
| Instance ID | 11076 | | Regular Expression | xxx([ST])Px | | Motif Instance | PVKSPH | | Bait Uniprot Accession | Q9Y6H5 | | Bait Uniprot Identifier | SNCAP_HUMAN | | Bait Gene Name | SNCAIP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 212-217 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down | | Interaction ID | 21076 | | Interacting Domain | WW domain | | Disease Association(s) | Parkinson disease | | Inhibitor(s) | Unknown | | Reference(s) | 16365047 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-215-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions |
Record No : 29 |
| Instance ID | 11077 | | Regular Expression | xxx([ST])Px | | Motif Instance | PVLSPM | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 409-414 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Pull down; Co-IP | | Interaction ID | 21077 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15175157 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Ser(412)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73 |
Record No : 30 |
| Instance ID | 11078 | | Regular Expression | xxx([ST])Px | | Motif Instance | SAATPN | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 439-444 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Pull down; Co-IP | | Interaction ID | 21078 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15175157 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(442)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73 |
Record No : 31 |
| Instance ID | 11079 | | Regular Expression | xxx([ST])Px | | Motif Instance | SHCTPP | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 479-484 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Pull down; Co-IP | | Interaction ID | 21079 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15175157 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(482)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73 |
Record No : 32 |
| Instance ID | 11080 | | Regular Expression | xxx([ST])Px | | Motif Instance | VEQTPK | | Bait Uniprot Accession | P46527 | | Bait Uniprot Identifier | CDN1B_HUMAN | | Bait Gene Name | CDKN1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 184-189 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; Co-IP; Mutation analysis | | Interaction ID | 21080 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19584057 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(187)-Pro motif in human Cyclin-dependent kinase inhibitor p27 (CDKN1B) catalyzes the cis-trans conformational changes of KIP1 and mediates its stability through the polyubiquitination mechanism |
Record No : 33 |
| Instance ID | 11081 | | Regular Expression | xxx([ST])Px | | Motif Instance | LACTPT | | Bait Uniprot Accession | P25322 | | Bait Uniprot Identifier | CCND1_MOUSE | | Bait Gene Name | Ccnd1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 283-288 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 21081 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11805292 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 directly binds to mouse G1/S-specific cyclin-D1 phosphorylated on Thr-286-Pro, thereby positively regulating cyclin-D1 function at the transcriptional level |
Record No : 34 |
| Instance ID | 11082 | | Regular Expression | xxx([ST])Px | | Motif Instance | MLGSPV | | Bait Uniprot Accession | P35222 | | Bait Uniprot Identifier | CTNB1_HUMAN | | Bait Gene Name | CTNNB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 243-248 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21082 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11533658 | | Comments | The phosphorylation-dependent interaction between the WW domain of Mouse Peptidyl-prolyl cis-trans isomerase Pin1 and Ser-246-Pro motif in human Beta-catenin |
Record No : 35 |
| Instance ID | 11083 | | Regular Expression | xxx([ST])Px | | Motif Instance | LLTSPD | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 60-65 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning; EMSA | | Interaction ID | 21083 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11432833 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser63-Pro motif of human Proto-oncogene c-Jun |
Record No : 36 |
| Instance ID | 11084 | | Regular Expression | xxx([ST])Px | | Motif Instance | LLPTPP | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 55-60 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Alanine scanning | | Interaction ID | 21084 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15048125 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-58-Pro motif of human MYC proto-oncogene protein |
Record No : 37 |
| Instance ID | 11085 | | Regular Expression | xxx([ST])Px | | Motif Instance | KKASPE | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 400-405 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21085 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-403-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 38 |
| Instance ID | 11086 | | Regular Expression | xxx([ST])Px | | Motif Instance | GPPSPR | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 524-529 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21086 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-527-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 39 |
| Instance ID | 11087 | | Regular Expression | xxx([ST])Px | | Motif Instance | DAGSPN | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 201-206 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21087 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-204-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 40 |
| Instance ID | 11088 | | Regular Expression | xxx([ST])Px | | Motif Instance | TPSTPG | | Bait Uniprot Accession | Q9BR01 | | Bait Uniprot Identifier | ST4A1_HUMAN | | Bait Gene Name | SULT4A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 8-13 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H; Co-IP; Mutation analysis | | Interaction ID | 21088 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19439498, 20920535 | | Comments | The human cytosolic Aryl Sulfotransferase 4A1 interacts with the human Peptidyl-prolyl cis-trans isomerase PIN1 through its Thr-11-Pro motif |
Record No : 41 |
| Instance ID | 11089 | | Regular Expression | xxx([ST])Px | | Motif Instance | SAPSPS | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 137-142 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down(GST tag) | | Interaction ID | 21089 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its Ser-140-Pro motif to promote mitogenesis and tumor growth |
Record No : 42 |
| Instance ID | 11090 | | Regular Expression | xxx([ST])Px | | Motif Instance | DLPSPP | | Bait Uniprot Accession | Q8BUV3 | | Bait Uniprot Identifier | GEPH_MOUSE | | Bait Gene Name | Gphn | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 185-190 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Mutation analysis | | Interaction ID | 21090 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17347650 | | Comments | The Mouse microtubule binding protein Gephyrin (Gphn) undergoes proline-directed phosphorylation, which is followed by the recruitment of the Mouse Peptidyl-prolyl cis-trans isomerase Pin1 through the Ser-188-Pro motif, which triggers conformational changes in the Gephyrin molecule, thus enhancing its ability to bind the beta subunit of glycine receptors |
Record No : 43 |
| Instance ID | 11091 | | Regular Expression | xxx([ST])Px | | Motif Instance | LGGTPT | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 2129-2134 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Co-IP; Alanine scanning | | Interaction ID | 21091 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19151708 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-2132-Pro motif of human NOTCH1, thereby enhancing NOTCH1 transcriptional and tumorigenic activity |
Record No : 44 |
| Instance ID | 11092 | | Regular Expression | xxx([ST])Px | | Motif Instance | KLASPE | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 70-75 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning; EMSA | | Interaction ID | 21092 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11432833 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser73-Pro motif of human Proto-oncogene c-Jun |
Record No : 45 |
| Instance ID | 11093 | | Regular Expression | xxx([ST])Px | | Motif Instance | PPGTPA | | Bait Uniprot Accession | Q99K48 | | Bait Uniprot Identifier | NONO_MOUSE | | Bait Gene Name | Nono | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 409-414 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase assay | | Interaction ID | 21093 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15701524 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-412-Pro motif of mouse NonO protein |
Record No : 46 |
| Instance ID | 11094 | | Regular Expression | xxx([ST])Px | | Motif Instance | LGLTPP | | Bait Uniprot Accession | Q99K48 | | Bait Uniprot Identifier | NONO_MOUSE | | Bait Gene Name | Nono | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 427-432 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase assay | | Interaction ID | 21094 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15701524 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-430-Pro motif of mouse NonO protein |
Record No : 47 |
| Instance ID | 11095 | | Regular Expression | xxx([ST])Px | | Motif Instance | IGGTPP | | Bait Uniprot Accession | Q99K48 | | Bait Uniprot Identifier | NONO_MOUSE | | Bait Gene Name | Nono | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 449-454 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase assay | | Interaction ID | 21095 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15701524 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-452-Pro motif of mouse NonO protein |
Record No : 48 |
| Instance ID | 11096 | | Regular Expression | xxx([ST])Px | | Motif Instance | FAFSPP | | Bait Uniprot Accession | Q01860 | | Bait Uniprot Identifier | PO5F1_HUMAN | | Bait Gene Name | POU5F1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 9-14 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21096 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21296877 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser(12)-Pro motif of human Octamer-binding protein 4 (OCT4/POU5F1) and functions as a putative regulator of the induction and maintenance of pluripotency |
Record No : 49 |
| Instance ID | 11097 | | Regular Expression | xxx([ST])Px | | Motif Instance | YQLSPP | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Bait Organism | Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) | | Sequence Position | 157-162 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21097 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19338781 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein by interacting with its phosphorylated Ser160-Pro motif and thereby promotes malignant transformation |
Record No : 50 |
| Instance ID | 11098 | | Regular Expression | xxx([ST])Px | | Motif Instance | EASTPE | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 229-234 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21098 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-232-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 51 |
| Instance ID | 11099 | | Regular Expression | xxx([ST])Px | | Motif Instance | PLCTPV | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 322-327 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21099 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-325-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 52 |
| Instance ID | 11100 | | Regular Expression | xxx([ST])Px | | Motif Instance | VTCTPG | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 328-333 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21100 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-331-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 53 |
| Instance ID | 11101 | | Regular Expression | xxx([ST])Px | | Motif Instance | SLSSPT | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 371-376 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21101 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Ser-374-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 54 |
| Instance ID | 11102 | | Regular Expression | xxx([ST])Px | | Motif Instance | SSPSPS | | Bait Uniprot Accession | P69713 | | Bait Uniprot Identifier | X_HBVA3 | | Bait Gene Name | X | | Bait Organism | Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A) | | Sequence Position | 38-43 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Co-IP; Pull down(GST tag) | | Interaction ID | 21102 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17383430 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-41-Pro motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis |
Record No : 55 |
| Instance ID | 11103 | | Regular Expression | xxx([ST])Px | | Motif Instance | HVETPE | | Bait Uniprot Accession | P31749 | | Bait Uniprot Identifier | AKT1_HUMAN | | Bait Gene Name | AKT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 89-94 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21103 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19448664 | | Comments | The human oncogenic Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-92-Pro motif of human serine/threonine Protein kinase B alpha (PKB alpha, also known as AKT1/Proto-oncogene c-Akt) to protect Akt from degradation |
Record No : 56 |
| Instance ID | 11104 | | Regular Expression | xxx([ST])Px | | Motif Instance | ITITPP | | Bait Uniprot Accession | P31749 | | Bait Uniprot Identifier | AKT1_HUMAN | | Bait Gene Name | AKT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 447-452 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21104 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19448664 | | Comments | The human oncogenic Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-450-Pro motif of human serine/threonine Protein kinase B alpha (PKB alpha, also known as AKT1/Proto-oncogene c-Akt) to protect Akt from degradation |
Record No : 57 |
| Instance ID | 11105 | | Regular Expression | xxx([ST])Px | | Motif Instance | IIFSPK | | Bait Uniprot Accession | O64645 | | Bait Uniprot Identifier | SOC1_ARATH | | Bait Gene Name | SOC1 | | Bait Organism | Arabidopsis thaliana (Mouse-ear cress) | | Sequence Position | 46-51 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; Alanine scanning; Phosphatase assay; NMR; Pull down(GST tag); BiFC assay | | Interaction ID | 21105 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20129060 | | Comments | Arabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Ser-49-Pro motif of Arabidopsis MADS-box protein SOC1 and thereby regulates flowering time in Arabidopsis |
Record No : 58 |
| Instance ID | 11106 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPKSPS | | Bait Uniprot Accession | Q8BT07 | | Bait Uniprot Identifier | CEP55_MOUSE | | Bait Gene Name | Cep55 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 423-428 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Alanine scanning; Pull down | | Interaction ID | 21106 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19638580 | | Comments | The mouse peptidyl-prolyl isomerase Pin1 regulates the final stages of cytokinesis by binding to the Ser-426-Pro motif of mouse Centrosomal protein of 55 kDa (Cep55), an essential component of the midbody ring |
Record No : 59 |
| Instance ID | 11107 | | Regular Expression | xxx([ST])Px | | Motif Instance | EESSPS | | Bait Uniprot Accession | O64645 | | Bait Uniprot Identifier | SOC1_ARATH | | Bait Gene Name | SOC1 | | Bait Organism | Arabidopsis thaliana (Mouse-ear cress) | | Sequence Position | 192-197 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; Alanine scanning; Phosphatase assay | | Interaction ID | 21107 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20129060 | | Comments | Arabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Ser-195-Pro motif of Arabidopsis MADS-box protein SOC1 and thereby regulates flowering time in Arabidopsis |
Record No : 60 |
| Instance ID | 11108 | | Regular Expression | xxx([ST])Px | | Motif Instance | NRISPP | | Bait Uniprot Accession | Q61457 | | Bait Uniprot Identifier | CCNE1_MOUSE | | Bait Gene Name | Ccne1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 382-387 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 21108 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16223725 | | Comments | Prolyl isomerase Pin1 from Xenopus laevis interacts with the Ser-385-Pro motif of mouse G1/S-specific cyclin-E1 (Ccne1) |
Record No : 61 |
| Instance ID | 11109 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPPSPP | | Bait Uniprot Accession | P10276 | | Bait Uniprot Identifier | RARA_HUMAN | | Bait Gene Name | RARA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 74-79 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Mutation analysis; Pull down | | Interaction ID | 21109 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15670742 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-77-Pro motif of human Retinoic acid receptor alpha and induces its degradation |
Record No : 62 |
| Instance ID | 11110 | | Regular Expression | xxx([ST])Px | | Motif Instance | ARSSPE | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 502-507 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21110 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-505-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 63 |
| Instance ID | 11111 | | Regular Expression | xxx([ST])Px | | Motif Instance | KAVSPP | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 515-520 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21111 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-518-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 64 |
| Instance ID | 11112 | | Regular Expression | xxx([ST])Px | | Motif Instance | SAKTPG | | Bait Uniprot Accession | Q9NY61 | | Bait Uniprot Identifier | AATF_HUMAN | | Bait Gene Name | AATF | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 143-148 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21112 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17468107 | | Comments | In response to apoptotic stimuli, human Peptidyl-prolyl cis-trans isomerase PIN1 binds the phosphorylated Thr-146-Pro motif of human Rb-binding protein CHE1/AATF and affects its stability by increasing its capacity to interact with HDM2 |
Record No : 65 |
| Instance ID | 11113 | | Regular Expression | xxx([ST])Px | | Motif Instance | ERITPL | | Bait Uniprot Accession | P54274 | | Bait Uniprot Identifier | TERF1_HUMAN | | Bait Gene Name | TERF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 146-151 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21113 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19060891 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr149–Pro motif in the human Telomeric protein Pin2/TRF1 in a phosphorylation-dependent and mitosis-specific manner and acts as an essential regulator of TRF1 stability, telomere maintenance and ageing |
Record No : 66 |
| Instance ID | 11114 | | Regular Expression | xxx([ST])Px | | Motif Instance | IPETPP | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 176-181 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21114 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 21685363, 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-179-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 67 |
| Instance ID | 11115 | | Regular Expression | xxx([ST])Px | | Motif Instance | NPMSPA | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 210-215 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21115 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-213-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 68 |
| Instance ID | 11116 | | Regular Expression | xxx([ST])Px | | Motif Instance | PNLSPN | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 205-210 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21116 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-208-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 69 |
| Instance ID | 11117 | | Regular Expression | xxx([ST])Px | | Motif Instance | AAPTPA | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 78-83 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21117 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12397362 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-81-Pro motif of human Cellular tumor antigen TP53 and is involved in the regulation of its stability and transcriptional activities |
Record No : 70 |
| Instance ID | 11118 | | Regular Expression | xxx([ST])Px | | Motif Instance | TSSSPQ | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 312-317 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21118 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12397362 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-315-Pro motif of human Cellular tumor antigen TP53 and is involved in the regulation of its stability and transcriptional activities |
Record No : 71 |
| Instance ID | 11119 | | Regular Expression | xxx([ST])Px | | Motif Instance | KPRSPV | | Bait Uniprot Accession | Q99MK8 | | Bait Uniprot Identifier | ARBK1_MOUSE | | Bait Gene Name | Adrbk1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 667-672 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Radiolabel; Alanine scanning; Co-IP; Pull down(GST tag) | | Interaction ID | 21119 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20080565 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-670-Pro motif of mouse G-protein-coupled receptor kinase 2 (Grk2/Adrbk1) for its subsequent degradation |
Record No : 72 |
| Instance ID | 11120 | | Regular Expression | xxx([ST])Px | | Motif Instance | KKTSPL | | Bait Uniprot Accession | P35991 | | Bait Uniprot Identifier | BTK_MOUSE | | Bait Gene Name | Btk | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 18-23 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Alanine scanning | | Interaction ID | 21120 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16644721 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-21-Pro motif of mouse Tyrosine-protein kinase Btk in a cell cycle-dependent manner, thereby regulating the Btk expression level |
Record No : 73 |
| Instance ID | 11121 | | Regular Expression | xxx([ST])Px | | Motif Instance | YVFSPT | | Bait Uniprot Accession | P35991 | | Bait Uniprot Identifier | BTK_MOUSE | | Bait Gene Name | Btk | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 112-117 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Alanine scanning | | Interaction ID | 21121 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16644721 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-115-Pro motif of mouse Tyrosine-protein kinase Btk in a cell cycle-dependent manner, thereby regulating the Btk expression level |
Record No : 74 |
| Instance ID | 11122 | | Regular Expression | xxx([ST])Px | | Motif Instance | SGRSPR | | Bait Uniprot Accession | Q14653 | | Bait Uniprot Identifier | IRF3_HUMAN | | Bait Gene Name | IRF3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 336-341 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Western blot; Co-IP; Mutation analysis | | Interaction ID | 21122 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16699525 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Ser339-Pro340 motif of human Interferon regulatory factor 3 (IRF3) |
Record No : 75 |
| Instance ID | 11123 | | Regular Expression | xxx([ST])Px | | Motif Instance | THGTPA | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1238-1243 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Y2H; Co-IP | | Interaction ID | 21123 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18838553 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Thr-1241-Pro motif of human Nuclear receptor corepressor 2 (NCOR2)/SMRT |
Record No : 76 |
| Instance ID | 11124 | | Regular Expression | xxx([ST])Px | | Motif Instance | LRHTPE | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1441-1446 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Y2H; Co-IP | | Interaction ID | 21124 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18838553 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Thr-1444-Pro motif of human Nuclear receptor corepressor 2 (NCOR2)/SMRT |
Record No : 77 |
| Instance ID | 11125 | | Regular Expression | xxx([ST])Px | | Motif Instance | PYASPP | | Bait Uniprot Accession | P33242 | | Bait Uniprot Identifier | STF1_MOUSE | | Bait Gene Name | Nr5a1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 200-205 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 21125 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19995909 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 facilitates the Ser-203 phosphorylation-dependent ubiquitination ubiquitination of mouse Steroidogenic factor 1 (Nr5a1) to regulate gonadotropin beta-subunit gene transcription |
Record No : 78 |
| Instance ID | 11126 | | Regular Expression | xxx([ST])Px | | Motif Instance | GCDSPD | | Bait Uniprot Accession | Q8CFN5 | | Bait Uniprot Identifier | MEF2C_MOUSE | | Bait Gene Name | Mef2c | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 95-100 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Western blot; Co-IP; Alanine scanning; Pull down | | Interaction ID | 21126 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801874 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts selectively with the phosphorylated Ser-98-Pro motif of mouse Myocyte-specific enhancer factor 2C (Mef2c) in skeletal muscle cells and acts as a regulator of muscle terminal differentiation |
Record No : 79 |
| Instance ID | 11127 | | Regular Expression | xxx([ST])Px | | Motif Instance | EAETPS | | Bait Uniprot Accession | Q9BR01 | | Bait Uniprot Identifier | ST4A1_HUMAN | | Bait Gene Name | SULT4A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 5-10 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H; Co-IP; Mutation analysis | | Interaction ID | 21127 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19439498, 20920535 | | Comments | The human cytosolic Aryl Sulfotransferase 4A1 interacts with the human Peptidyl-prolyl cis-trans isomerase PIN1 through its Thr-8-Pro motif |
Record No : 80 |
| Instance ID | 11128 | | Regular Expression | xxx([ST])Px | | Motif Instance | VGHSPE | | Bait Uniprot Accession | Q8CFN5 | | Bait Uniprot Identifier | MEF2C_MOUSE | | Bait Gene Name | Mef2c | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 107-112 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Western blot; Co-IP; Alanine scanning; Pull down | | Interaction ID | 21128 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801874 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts selectively with the phosphorylated Ser-110-Pro motif of mouse Myocyte-specific enhancer factor 2C (Mef2c) in skeletal muscle cells and acts as a regulator of muscle terminal differentiation |
Record No : 81 |
| Instance ID | 11129 | | Regular Expression | xxx([ST])Px | | Motif Instance | VQISPD | | Bait Uniprot Accession | Q92945 | | Bait Uniprot Identifier | FUBP2_HUMAN | | Bait Gene Name | KHSRP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 178-183 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 21129 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19770516 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Ser-181-Pro motif of human KH type-splicing regulatory protein (KHSRP)/FUSE-binding protein 2 (FUBP2) |
Record No : 82 |
| Instance ID | 11130 | | Regular Expression | xxx([ST])Px | | Motif Instance | QEISPP | | Bait Uniprot Accession | Q05397 | | Bait Uniprot Identifier | FAK1_HUMAN | | Bait Gene Name | PTK2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 907-912 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy; Western blot; Pull down; Mutation analysis | | Interaction ID | 21130 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19595712 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-910-Pro motif of human Focal adhesion kinase 1 (FAK1) and may thereby play a role in Ras-related tumor metastasis |
Record No : 83 |
| Instance ID | 11131 | | Regular Expression | xxx([ST])Px | | Motif Instance | YGSSPC | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 431-436 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Alanine scanning; Mutation analysis | | Interaction ID | 21131 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21454638 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphoserine 434-containing motif in human Insulin receptor substrate 1 (IRS1) through its WW domain and enhances insulin actions and adipogenesis |
Record No : 84 |
| Instance ID | 11132 | | Regular Expression | xxx([ST])Px | | Motif Instance | EVESPT | | Bait Uniprot Accession | P06876 | | Bait Uniprot Identifier | MYB_MOUSE | | Bait Gene Name | Myb | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 525-530 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 21132 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18359295 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-528-Pro motif in mouse Transcriptional activator Myb |
Record No : 85 |
| Instance ID | 11133 | | Regular Expression | xxx([ST])Px | | Motif Instance | GPQSPG | | Bait Uniprot Accession | P14598 | | Bait Uniprot Identifier | NCF1_HUMAN | | Bait Gene Name | NCF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 342-347 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Pull down | | Interaction ID | 21133 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20956805 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to human Neutrophil cytosol factor 1 (NCF1)/p47phox on phosphorylated Ser345, thereby inducing conformational changes that facilitate p47phox phosphorylation on other sites by protein kinase C |
Record No : 86 |
| Instance ID | 11134 | | Regular Expression | xxx([ST])Px | | Motif Instance | AELSPA | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 428-433 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21134 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its Ser-431-Pro motif to promote mitogenesis and tumor growth |
Record No : 87 |
| Instance ID | 11135 | | Regular Expression | xxx([ST])Px | | Motif Instance | SATSPA | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 92-97 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21135 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its Ser-95-Pro motif to promote mitogenesis and tumor growth |
Record No : 88 |
| Instance ID | 11136 | | Regular Expression | xxx([ST])Px | | Motif Instance | LPMSPR | | Bait Uniprot Accession | P40763 | | Bait Uniprot Identifier | STAT3_HUMAN | | Bait Gene Name | STAT3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 724-729 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Alanine scanning | | Interaction ID | 21136 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17563747 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-727-Pro motif of human Acute-phase response factor STAT3 upon cytokine/growth factor stimulation and promotes STAT3 transcriptional activity |
Record No : 89 |
| Instance ID | 11137 | | Regular Expression | xxx([ST])Px | | Motif Instance | NPFTPD | | Bait Uniprot Accession | Q8QGV2 | | Bait Uniprot Identifier | WEE1B_XENLA | | Bait Gene Name | wee1-b | | Bait Organism | Xenopus laevis (African clawed frog) | | Sequence Position | 183-188 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Alanine scanning | | Interaction ID | 21137 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17360425 | | Comments | Prolyl isomerase Pin1 from Xenopus laevis specifically binds the phosphorylated Thr-186-Pro motif of Xenopus Zygotic wee1-like protein kinase 1B, the inhibitory kinase of cyclin B/Cdc2, for its catalytic inactivation at M phase of the mitotic cell cycle |
Record No : 90 |
| Instance ID | 11138 | | Regular Expression | xxx([ST])Px | | Motif Instance | PTTSPH | | Bait Uniprot Accession | Q8BUV3 | | Bait Uniprot Identifier | GEPH_MOUSE | | Bait Gene Name | Gphn | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 197-202 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Mutation analysis | | Interaction ID | 21138 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17347650 | | Comments | The Mouse microtubule binding protein Gephyrin (Gphn) undergoes proline-directed phosphorylation, which is followed by the recruitment of the Mouse Peptidyl-prolyl cis-trans isomerase Pin1 through the Ser-200-Pro motif, which triggers conformational changes in the Gephyrin molecule, thus enhancing its ability to bind the beta subunit of glycine receptors |
Record No : 91 |
| Instance ID | 11139 | | Regular Expression | xxx([ST])Px | | Motif Instance | PPLSPP | | Bait Uniprot Accession | Q8BUV3 | | Bait Uniprot Identifier | GEPH_MOUSE | | Bait Gene Name | Gphn | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 191-196 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Mutation analysis | | Interaction ID | 21139 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17347650 | | Comments | The Mouse microtubule binding protein Gephyrin (Gphn) undergoes proline-directed phosphorylation, which is followed by the recruitment of the Mouse Peptidyl-prolyl cis-trans isomerase Pin1 through the Ser-194-Pro motif, which triggers conformational changes in the Gephyrin molecule, thus enhancing its ability to bind the beta subunit of glycine receptors |
Record No : 92 |
| Instance ID | 11140 | | Regular Expression | xxx([ST])Px | | Motif Instance | SNQSPK | | Bait Uniprot Accession | Q90Z80 | | Bait Uniprot Identifier | FBX5A_XENLA | | Bait Gene Name | fbxo5-a | | Bait Organism | Xenopus laevis (African clawed frog) | | Sequence Position | 7-12 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21140 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17159919 | | Comments | Early mitotic inhibitor 1-A (Emi1/fbxo5-a) binding to Prolyl isomerase Pin1 of Xenopus laevis depends on the phosphorylation of Ser-10 of Emi1 and on the WW domain of Pin1 |
Record No : 93 |
| Instance ID | 11141 | | Regular Expression | xxx([ST])Px | | Motif Instance | YYMSPE | | Bait Uniprot Accession | Q9HC98 | | Bait Uniprot Identifier | NEK6_HUMAN | | Bait Gene Name | NEK6 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 212-217 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 21141 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16476580 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-215-Pro motif of human Serine/threonine-protein kinase NEK6 |
Record No : 94 |
| Instance ID | 11142 | | Regular Expression | xxx([ST])Px | | Motif Instance | ALQSPF | | Bait Uniprot Accession | Q9HC98 | | Bait Uniprot Identifier | NEK6_HUMAN | | Bait Gene Name | NEK6 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 242-247 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 21142 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16476580 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-245-Pro motif of human Serine/threonine-protein kinase NEK6 |
Record No : 95 |
| Instance ID | 11143 | | Regular Expression | xxx([ST])Px | | Motif Instance | LVRSPQ | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 2118-2123 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Western blot; Co-IP; Pull down(GST tag); Alanine scanning | | Interaction ID | 21143 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19151708 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds directly to human NOTCH1 at the Ser-2121-Pro motif and regulates its activity, cooperating with NOTCH1 in tumorigenesis |
Record No : 96 |
| Instance ID | 11144 | | Regular Expression | xxx([ST])Px | | Motif Instance | AYLSPP | | Bait Uniprot Accession | Q3U182 | | Bait Uniprot Identifier | CRTC2_MOUSE | | Bait Gene Name | Crtc2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 133-138 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Alanine scanning | | Interaction ID | 21144 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20675384 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 associates with and induces translocation of mouse CREB-regulated transcription coactivator 2 (Crtc2) to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity |
Record No : 97 |
| Instance ID | 11145 | | Regular Expression | xxx([ST])Px | | Motif Instance | PTLSPP | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 2133-2138 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Western blot; Co-IP; Pull down(GST tag); Alanine scanning | | Interaction ID | 21145 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19151708 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds directly to human NOTCH1 at the Ser-2136-Pro motif and regulates its activity, cooperating with NOTCH1 in tumorigenesis |
Record No : 98 |
| Instance ID | 11146 | | Regular Expression | xxx([ST])Px | | Motif Instance | GRSSPS | | Bait Uniprot Accession | P78543 | | Bait Uniprot Identifier | BTG2_HUMAN | | Bait Gene Name | BTG2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 144-149 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 21146 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15788397 | | Comments | Phosphorylation of serine 147 of human NGF-inducible anti-proliferative protein PC3/BTG2 induces binding to human Peptidyl-prolyl cis-trans isomerase PIN1 in cytoplasm and cell death |
Record No : 99 |
| Instance ID | 11147 | | Regular Expression | xxx([ST])Px | | Motif Instance | AAVTPE | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 740-745 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot | | Interaction ID | 21147 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19602287 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds human Amyloid beta A4 protein (APP) phosphorylated on Thr-743 and regulates APP processing |
Record No : 100 |
| Instance ID | 11148 | | Regular Expression | xxx([ST])Px | | Motif Instance | QEISPP | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 907-912 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Pull down; Classical fluorescence spectroscopy; Mutation analysis; Western blot | | Interaction ID | 21148 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19595712 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the Ser-910-Pro motif of mouse Focal adhesion kinase 1 (Fak1/Ptk2) and may thereby play a role in Ras-related tumor metastasis |
Record No : 101 |
| Instance ID | 11149 | | Regular Expression | xxx([ST])Px | | Motif Instance | VFRTPP | | Bait Uniprot Accession | Q04206 | | Bait Uniprot Identifier | TF65_HUMAN | | Bait Gene Name | RELA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 251-256 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21149 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14690596 | | Comments | Upon cytokine treatment, human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-254-Pro motif in human Nuclear factor NF-kappa-B p65 subunit (RELA) and inhibits p65 binding to I-kappa-B-alpha, resulting in increased nuclear accumulation and protein stability of p65 and enhanced NF-kappa-B activity |
Record No : 102 |
| Instance ID | 11150 | | Regular Expression | xxx([ST])Px | | Motif Instance | EPASPP | | Bait Uniprot Accession | P37231 | | Bait Uniprot Identifier | PPARG_HUMAN | | Bait Gene Name | PPARG | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 81-86 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; SPR; Pull down; Mutation analysis; Co-IP | | Interaction ID | 21150 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19996102 | | Comments | The WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-84-Pro motif of human Peroxisome proliferator-activated receptor gamma (PPARG) and thereby regulates macrophage function |
Record No : 103 |
| Instance ID | 11151 | | Regular Expression | xxx([ST])Px | | Motif Instance | DSGTPL | | Bait Uniprot Accession | O82794 | | Bait Uniprot Identifier | AGL24_ARATH | | Bait Gene Name | AGL24 | | Bait Organism | Arabidopsis thaliana (Mouse-ear cress) | | Sequence Position | 199-204 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; NMR; Alanine scanning; Co-IP; Phosphatase assay; Pull down | | Interaction ID | 21151 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20129060 | | Comments | Arabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Thr-202-Pro motif of Arabidopsis MADS-box protein AGL24 and thereby regulates flowering time in Arabidopsis |
Record No : 104 |
| Instance ID | 11152 | | Regular Expression | xxx([ST])Px | | Motif Instance | PPLSPS | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 59-64 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Alanine scanning | | Interaction ID | 21152 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15048125 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-62-Pro motif of human MYC proto-oncogene protein |
Record No : 105 |
| Instance ID | 11153 | | Regular Expression | xxx([ST])Px | | Motif Instance | AASTPR | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 406-411 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21153 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Thr-409-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 106 |
| Instance ID | 11154 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPRSPV | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 527-532 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21154 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-530-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 107 |
| Instance ID | 11155 | | Regular Expression | xxx([ST])Px | | Motif Instance | VVRTPP | | Bait Uniprot Accession | P10636 | | Bait Uniprot Identifier | TAU_HUMAN | | Bait Gene Name | MAPT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 228-233 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | ELISA; Alanine scanning; Pull down | | Interaction ID | 21155 | | Interacting Domain | WW domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 10391244 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 exhibits specific and high-affinity binding to the phosphorylated Thr-231-Pro motif of Isoform Tau-F (Tau-4) of human Microtubule-associated protein tau (MAPT) |
Record No : 108 |
| Instance ID | 11156 | | Regular Expression | xxx([ST])Px | | Motif Instance | ASQSPR | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 175-180 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis; Co-IP | | Interaction ID | 21156 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17938171 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-178-Pro motif in the human Death domain-associated protein 6 (DAXX) and plays an important role in the negative regulation of DAXX, thereby inhibiting the oxidative stress-induced cellular apoptotic response |
Record No : 109 |
| Instance ID | 11157 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPSTPS | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 140-145 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down(GST tag) | | Interaction ID | 21157 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its phosphorylated Thr-143-Pro motif to promote mitogenesis and tumor growth |
Record No : 110 |
| Instance ID | 11158 | | Regular Expression | xxx([ST])Px | | Motif Instance | GCTTPV | | Bait Uniprot Accession | Q96Q89 | | Bait Uniprot Identifier | KI20B_HUMAN | | Bait Gene Name | KIF20B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1601-1606 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Co-IP | | Interaction ID | 21158 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11470801 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-1604-Pro motif of Isoform 3 of human Kinesin-like protein KIF20B |
Record No : 111 |
| Instance ID | 11159 | | Regular Expression | xxx([ST])Px | | Motif Instance | CSATPT | | Bait Uniprot Accession | Q969H0 | | Bait Uniprot Identifier | FBXW7_HUMAN | | Bait Gene Name | FBXW7 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 202-207 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 21159 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22608923 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-205-Pro motif of human F-box protein FBXW7, the substrate recognition component of the SCF E3 ligase complex, and promotes Fbw7 self-ubiquitination and protein degradation, thereby negatively regulating its tumor suppressor function |
Record No : 112 |
| Instance ID | 11198 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q64213 | | Bait Uniprot Identifier | SF01_MOUSE | | Bait Gene Name | Sf1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 575-578 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Alanine scanning; Far Western blotting; SPR | | Interaction ID | 21198 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9171351 | | Comments | The PPLP motif in mouse Splicing factor 1 (Sf1) that is recognized by the group II WW domain of mouse Formin-binding protein 11 (Fbp11) |
Record No : 113 |
| Instance ID | 11199 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q05860 | | Bait Uniprot Identifier | FMN1_MOUSE | | Bait Gene Name | Fmn1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 877-880 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Alanine scanning; Far Western blotting; Pull down(GST tag); Competition binding | | Interaction ID | 21199 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9171351, 8605874 | | Comments | The PPLP motif in mouse Formin-1 (Fmn1) that is recognized by the group II WW domain of mouse Formin-binding protein 11 (Fbp11) |
Record No : 114 |
| Instance ID | 11200 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q03173 | | Bait Uniprot Identifier | ENAH_MOUSE | | Bait Gene Name | Enah | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 602-605 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Peptide array; Far Western blotting; Co-IP; Pull down(GST tag); Competition binding | | Interaction ID | 21200 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9407065 | | Comments | The PPLP motif in mouse Mena (Enah), the mammalian homolog of Drosophila Enabled, that is recognized by the group II WW domain of mouse neural protein Fe65 (Apbb1) |
Record No : 115 |
| Instance ID | 11215 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYPTDCSI | | Bait Uniprot Accession | Q9H3D4 | | Bait Uniprot Identifier | P63_HUMAN | | Bait Gene Name | TP63 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 540-549 | | Critical Residues | P1; P2; P4; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; Fluorescence | | Interaction ID | 21215 | | Interacting Domain | WW domain | | Disease Association(s) | Hay-Wells syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Tumor protein TP63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation |
Record No : 116 |
| Instance ID | 11216 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYPTDCSI | | Bait Uniprot Accession | O88898 | | Bait Uniprot Identifier | P63_MOUSE | | Bait Gene Name | Tp63 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 540-549 | | Critical Residues | P1; P2; P4; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; Fluorescence | | Interaction ID | 21216 | | Interacting Domain | WW domain | | Disease Association(s) | Hay-Wells syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Tumor protein Tp63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation |
Record No : 117 |
| Instance ID | 11217 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYPTDCSI | | Bait Uniprot Accession | Q9JJP6 | | Bait Uniprot Identifier | P63_RAT | | Bait Gene Name | Tp63 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 540-549 | | Critical Residues | P1; P2; P4; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; Fluorescence | | Interaction ID | 21217 | | Interacting Domain | WW domain | | Disease Association(s) | Hay-Wells syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Rat E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and rat Tumor protein Tp63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation |
Record No : 118 |
| Instance ID | 11218 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYHADPSL | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 484-493 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21218 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Tumor protein TP73 interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 119 |
| Instance ID | 11219 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYHADPSL | | Bait Uniprot Accession | Q9JJP2 | | Bait Uniprot Identifier | P73_MOUSE | | Bait Gene Name | Tp73 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 478-487 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21219 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Tumor protein Tp73 interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 120 |
| Instance ID | 11220 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYHADPSL | | Bait Uniprot Accession | Q9XSK8 | | Bait Uniprot Identifier | P73_CHLAE | | Bait Gene Name | TP73 | | Bait Organism | Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) | | Sequence Position | 484-493 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21220 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, binds the Tumor protein P73 of African green monkey through the WW2 domain and the consensus PPxY or PY motif |
Record No : 121 |
| Instance ID | 11221 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYSVATSL | | Bait Uniprot Accession | Q9NV92 | | Bait Uniprot Identifier | NFIP2_HUMAN | | Bait Gene Name | NDFIP2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 174-183 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21221 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human NEDD4 WW domain-binding protein 5A (NDFIP2) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 122 |
| Instance ID | 11222 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYSVATSL | | Bait Uniprot Accession | Q91ZP6 | | Bait Uniprot Identifier | NFIP2_MOUSE | | Bait Gene Name | Ndfip2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 149-158 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21222 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse NEDD4 WW domain-binding protein 5A (Ndfip2) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 123 |
| Instance ID | 11223 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYRHRNTV | | Bait Uniprot Accession | Q15303 | | Bait Uniprot Identifier | ERBB4_HUMAN | | Bait Gene Name | ERBB4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1298-1307 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21223 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Proto-oncogene-like protein c-ErbB-4 (ERBB4) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 124 |
| Instance ID | 11224 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYRHRNTV | | Bait Uniprot Accession | Q62956 | | Bait Uniprot Identifier | ERBB4_RAT | | Bait Gene Name | Erbb4 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 1298-1307 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21224 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Rat E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and rat Proto-oncogene-like protein c-ErbB-4 (Erbb4) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 125 |
| Instance ID | 11225 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYRHRNTV | | Bait Uniprot Accession | Q61527 | | Bait Uniprot Identifier | ERBB4_MOUSE | | Bait Gene Name | Erbb4 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 1298-1307 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21225 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Proto-oncogene-like protein c-ErbB-4 (Erbb4) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 126 |
| Instance ID | 11642 | | Regular Expression | PPxY | | Motif Instance | PPTY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 562-565 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21642 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12042308 | | Comments | PPxY motif (562-565) in synaptopodin that mediates its interaction with the second WW domain of MAGI-1 |
Record No : 127 |
| Instance ID | 11643 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 581-584 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21643 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12042308 | | Comments | PPxY motif (581-584) in synaptopodin that mediates its interaction with the second WW domain of MAGI-1 |
Record No : 128 |
| Instance ID | 11644 | | Regular Expression | PPxY | | Motif Instance | PPTY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 562-565 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21644 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596123 | | Comments | PPxY motif (562-565) in synaptopodin that mediates its interaction with both WW domains of KIBRA (WWC1) |
Record No : 129 |
| Instance ID | 11645 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 581-584 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21645 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596123 | | Comments | PPxY motif (581-584) in synaptopodin that mediates its interaction with both WW domains of KIBRA (WWC1) |
Record No : 130 |
| Instance ID | 11646 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 200-203 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21646 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12559952, 18596123 | | Comments | PPxY motif (200-203) in Dendrin that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 131 |
| Instance ID | 11647 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 224-227 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21647 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12559952, 18596123 | | Comments | PPxY motif (224-227) in Dendrin that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 132 |
| Instance ID | 11648 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 230-233 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21648 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12559952, 18596123 | | Comments | PPxY motif (230-233) in Dendrin that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 133 |
| Instance ID | 11649 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q08345 | | Bait Uniprot Identifier | DDR1_HUMAN | | Bait Gene Name | DDR1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 481-484 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21649 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18190796 | | Comments | PPxY motif of DDR1 that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 134 |
| Instance ID | 11650 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 200-203 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21650 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16464232 | | Comments | PPxY motif (200-203) in Dendrin that mediates its interaction with WW domains of MAGI-1 |
Record No : 135 |
| Instance ID | 11651 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 224-227 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21651 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16464232 | | Comments | PPxY motif (224-227) in Dendrin that mediates its interaction with WW domains of MAGI-1 |
Record No : 136 |
| Instance ID | 11652 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 230-233 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21652 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16464232 | | Comments | PPxY motif (230-233) in Dendrin that mediates its interaction with WW domains of MAGI-1 |
Record No : 137 |
| Instance ID | 11653 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q01196 | | Bait Uniprot Identifier | RUNX1_HUMAN | | Bait Gene Name | RUNX1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 355-358 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21653 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10228168 | | Comments | The PY motif (PPxY) in the subregion of the transcription activation domain of the DNA-binding subunit of human Runt-related transcription factor 1 (or PEBP2alpha) that mediates binding to the WW domain of human Yes-associated protein (YAP) |
Record No : 138 |
| Instance ID | 11654 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q03347 | | Bait Uniprot Identifier | RUNX1_MOUSE | | Bait Gene Name | Runx1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 354-357 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21654 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11118213 | | Comments | The PPxY motif of mouse Runt-related transcription factor 1 (or PEBP2alpha) that mediates binding to the WW domain of mouse WW domain-containing transcription regulator protein 1 (or Taz) |
Record No : 139 |
| Instance ID | 11983 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q92558 | | Bait Uniprot Identifier | WASF1_HUMAN | | Bait Gene Name | WASF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 430-433 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | PAX-MS | | Interaction ID | 21983 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22606326 | | Comments | PPLP motif in human WAVE1 (WASF1) recognized by the group II WW domain of GAS7 |
Record No : 140 |
| Instance ID | 11991 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P97765 | | Bait Uniprot Identifier | WBP2_MOUSE | | Bait Gene Name | Wbp2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 197-200 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21991 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7644498 | | Comments | The PY motif (197-200) of mouse WW domain-binding protein 2 (Wbp2) that binds to the WW domain of mouse Yes-associated protein (Yap1/Yap65) |
Record No : 141 |
| Instance ID | 11992 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P97765 | | Bait Uniprot Identifier | WBP2_MOUSE | | Bait Gene Name | Wbp2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 249-252 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21992 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7644498 | | Comments | The PY motif (249-252) of mouse WW domain-binding protein 2 (Wbp2) that binds to the WW domain of mouse Yes-associated protein (Yap1/Yap65) |
Record No : 142 |
| Instance ID | 11993 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Bait Organism | Bluetongue virus 10 (isolate USA) (BTV 10) | | Sequence Position | 36-39 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21993 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | Non-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human NEDD4-like E3 ubiquitin-protein ligase WWP1 |
Record No : 143 |
| Instance ID | 11994 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Bait Organism | Bluetongue virus 10 (isolate USA) (BTV 10) | | Sequence Position | 36-39 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21994 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | Non-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase Itchy homolog (ITCH) |
Record No : 144 |
| Instance ID | 11995 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P13285 | | Bait Uniprot Identifier | LMP2_EBVB9 | | Bait Gene Name | LMP2 | | Bait Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) | | Sequence Position | 98-101 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 21995 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11046148 | | Comments | The PY motif of Epstein-Barr virus Latent membrane protein 2 (LMP2) binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439 and may thereby regulate B-cell receptor (BCR) signaling |
Record No : 145 |
| Instance ID | 11996 | | Regular Expression | xxx([ST])Px | | Motif Instance | MLGSPV | | Bait Uniprot Accession | Q02248 | | Bait Uniprot Identifier | CTNB1_MOUSE | | Bait Gene Name | Ctnnb1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 243-248 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21996 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11533658 | | Comments | The phosphorylation-dependent interaction between the WW domain of Mouse Peptidyl-prolyl cis-trans isomerase Pin1 and Ser-246-Pro motif in mouse Beta-catenin (Ctnnb1) |
Record No : 146 |
| Instance ID | 12056 | | Regular Expression | [ILFVYM][ILFVYM]PPPPxxP | | Motif Instance | YIPPPPAEP | | Bait Uniprot Accession | Q8WXI2 | | Bait Uniprot Identifier | CNKR2_HUMAN | | Bait Gene Name | CNKSR2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 352-360 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22056 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24656827 | | Comments | Human CNK homolog protein 2 (CNK2)/ Connector enhancer of KSR 2 (CNKSR2) interacts with the N-terminal region of human Rho GTPase-activating protein 39 (ARHGAP39) through a short proline-rich WW domain-binding motif and thereby modulates Rac cycling during spine morphogenesis in hippocampal neurons |
Record No : 147 |
| Instance ID | 12057 | | Regular Expression | [IL]DLPxY | | Motif Instance | LDLPPY | | Bait Uniprot Accession | Q96PU5 | | Bait Uniprot Identifier | NED4L_HUMAN | | Bait Gene Name | NEDD4L | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 846-851 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR | | Interaction ID | 22057 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25295397 | | Comments | The PY motif in the HECT domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439 binds to the WW3 domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439, suggesting a possible auto-ubquitination mechanism using two molecules, a partially unfolded one and a fully functional NEDD4L counterpart |
Record No : 148 |
| Instance ID | 12066 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 538-541 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22066 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The PPXY motif of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 that binds to the WW domain of Rat HECT domain E3 ubiquitin ligase Atrophin Interacting Protein AIP4/Itch |
Record No : 149 |
| Instance ID | 12067 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 538-541 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22067 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The PPXY motif of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 that binds to the WW domain of Rat E3 ubiquitin-protein ligase Nedd4 |
Record No : 150 |
| Instance ID | 12074 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | Q8WWW0 | | Bait Uniprot Identifier | RASF5_HUMAN | | Bait Gene Name | RASSF5 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 21-24 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22074 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23538446 | | Comments | The PPXY motif of Human Ras association domain-containing protein 5 (RASSF5) that binds to the WW domains of Human E3 ubiquitin-protein ligase Itchy homolog (ITCH) thereby promoting the proteasomal degradation of RASSF5 |
Record No : 151 |
| Instance ID | 12195 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q96B67 | | Bait Uniprot Identifier | ARRD3_HUMAN | | Bait Gene Name | ARRDC3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 346-349 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 22195 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24379409 | | Comments | The PPXY motif (346-349) of human Arrestin domain-containing protein 3 (ARRDC3) that binds to the WW domains of human E3 ubiquitin-protein ligase NEDD4 |
Record No : 152 |
| Instance ID | 12196 | | Regular Expression | PPxY | | Motif Instance | PPLY | | Bait Uniprot Accession | Q96B67 | | Bait Uniprot Identifier | ARRD3_HUMAN | | Bait Gene Name | ARRDC3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 391-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Sequence based prediction; ITC | | Interaction ID | 22196 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24379409 | | Comments | The PPXY motif (391-394) of human Arrestin domain-containing protein 3 (ARRDC3) that binds to the WW domains of human E3 ubiquitin-protein ligase NEDD4 |
Record No : 153 |
| Instance ID | 12206 | | Regular Expression | (Rx{1,3}PPGPPP)|(PPGPPPx{1,3}R)|(Rx{1,3}PPGPPPx{1,3}R) | | Motif Instance | RKPPGPPP | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 197-204 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis; Pull down(GST tag); Y2H; Co-IP | | Interaction ID | 22206 | | Interacting Domain | WW domain | | Disease Association(s) | Golabi-Ito-Hall syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 10593949, 20410308 | | Comments | Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 (polyglutamine tract-binding protein 1 or Npw38) affects its binding to WBP-11 (WW domain-binding protein 11 or NpwBP) via a novel proline-rich motif (197-204) and deregulates pre-mRNA splicing |
Record No : 154 |
| Instance ID | 12207 | | Regular Expression | (Rx{1,3}PPGPPP)|(PPGPPPx{1,3}R)|(Rx{1,3}PPGPPPx{1,3}R) | | Motif Instance | RLLPPGPPPGR | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 456-466 | | Critical Residues | P1; P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis; Pull down(GST tag); Y2H; Co-IP | | Interaction ID | 22207 | | Interacting Domain | WW domain | | Disease Association(s) | Golabi-Ito-Hall syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 10593949, 20410308 | | Comments | Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 (polyglutamine tract-binding protein 1 or Npw38) affects its binding to WBP-11 (WW domain-binding protein 11 or NpwBP) via a novel proline-rich motif (456-466) and deregulates pre-mRNA splicing |
Record No : 155 |
| Instance ID | 12208 | | Regular Expression | xPPRx | | Motif Instance | PPPRG | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 482-486 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Pull down | | Interaction ID | 22208 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19592703 | | Comments | The PPR motif in human splicing factor SIPP1 or WBP11 which mediates its interaction with the WW domains of human FBP21 or WBP4 |
Record No : 156 |
| Instance ID | 12209 | | Regular Expression | xPPRx | | Motif Instance | PPPRG | | Bait Uniprot Accession | Q923D5 | | Bait Uniprot Identifier | WBP11_MOUSE | | Bait Gene Name | Wbp11 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 482-486 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide library screening; Pull down(GST tag) | | Interaction ID | 22209 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10744724 | | Comments | The PPR motif in mouse splicing factor SIPP1 or WBP11 which mediates its interaction with the WW domains of mouse FBP21 or WBP4 |
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