Instance ID10004
Regular ExpressionRx[^P]([ST])[^P]P
Motif InstanceRRWSAP
Bait Uniprot AccessionP54253
Bait Uniprot IdentifierATX1_HUMAN
Bait Gene NameATXN1
Bait OrganismHomo sapiens (Human)
Sequence Position772-777
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)NMR; Co-IP; Mutation analysis; Y2H
Interaction ID20004
Interacting Domain14-3-3 domain
Disease Association(s)Spinocerebellar ataxia type 1
Inhibitor(s)Unknown
Reference(s)20037628, 12757707
Comments14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)