Instance ID10014
Regular ExpressionRx[^P]([ST])[^P]P
Motif InstanceRTISAP
Bait Uniprot AccessionO15151
Bait Uniprot IdentifierMDM4_HUMAN
Bait Gene NameMDM4
Bait OrganismHomo sapiens (Human)
Sequence Position364-369
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Competition binding; Mutation analysis
Interaction ID20014
Interacting Domain14-3-3 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16943424, 16227609
CommentsConsensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein epsilon

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)