Instance ID10023
Regular ExpressionRx[^P]([ST])[^P]P
Motif InstanceRSTSTP
Bait Uniprot AccessionP04049
Bait Uniprot IdentifierRAF1_HUMAN
Bait Gene NameRAF1
Bait OrganismHomo sapiens (Human)
Sequence Position256-261
Critical ResiduesP1; P2; P4; P6
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Display technology
Interaction ID20023
Interacting Domain14-3-3 domain
Disease Association(s)Cancer; Noonan Syndrome
Inhibitor(s)Unknown
Reference(s)20679480, 8601312, 17603483
Comments14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein tau

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)