Instance ID10024
Regular ExpressionRx[^P]([ST])[^P]P
Motif InstanceRAHSSP
Bait Uniprot AccessionP46937
Bait Uniprot IdentifierYAP1_HUMAN
Bait Gene NameYAP1
Bait OrganismHomo sapiens (Human)
Sequence Position124-129
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis; Pull down
Interaction ID20024
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12535517, 17974916
CommentsAkt phosphorylates the Yes-associated protein, at serine 127, to induce interaction with 14-3-3 protein tau and attenuation of p73-mediated apoptosis

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)