Instance ID10026
Regular ExpressionRx[^P]([ST])[^P]P
Motif InstanceRSRSAP
Bait Uniprot AccessionQ61337
Bait Uniprot IdentifierBAD_MOUSE
Bait Gene NameBad
Bait OrganismMus musculus (Mouse)
Sequence Position133-138
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis
Interaction ID20026
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10949026, 8929531
CommentsPhosphorylation of the proapoptotic Bcl-2 family member BAD at Ser-136 recruits 14-3-3 protein zeta that then function to increase the accessibility of Ser-155 to survival-promoting kinases

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)