Instance ID10033
Regular ExpressionRxx[^P]([ST])[IVLM]x
Motif InstanceRSAGSIP
Bait Uniprot AccessionQ04206
Bait Uniprot IdentifierTF65_HUMAN
Bait Gene NameRELA
Bait OrganismHomo sapiens (Human)
Sequence Position41-47
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Ser-P5
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down
Interaction ID20033
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16931600
Comments14-3-3 binding site in human Transcription factor NF-kappa-B p65 subunit (or RELA) that binds to 14-3-3 protein eta in response to TNFalpha stimulation, which indicates that 14-3-3 proteins facilitate the nuclear export of IkappaBalpha-p65 complexes and are required for the appropriate regulation of NFkappaB signaling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)