Instance ID10043
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceHSRSIP
Bait Uniprot AccessionP35568
Bait Uniprot IdentifierIRS1_HUMAN
Bait Gene NameIRS1
Bait OrganismHomo sapiens (Human)
Sequence Position371-376
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Competition binding
Interaction ID20043
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9312143
CommentsPhosphoserine-containing 14-3-3 binding motif (pS-374) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)