Instance ID10049
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRAQSSP
Bait Uniprot AccessionP56524
Bait Uniprot IdentifierHDAC4_HUMAN
Bait Gene NameHDAC4
Bait OrganismHomo sapiens (Human)
Sequence Position629-634
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20049
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10869435
CommentsPhosphoserine-containing 14-3-3 binding motif (pS-632) in human Histone deacetylase 4 that mediates interaction with 14-3-3 protein epsilon and results in the sequestration of HDAC4 in the cytoplasm, wheras loss of this interaction allows HDAC4 to translocate to the nucleus, interact with HDAC3, and repress gene expression

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)