Instance ID10051
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRSSTPP
Bait Uniprot AccessionP43565
Bait Uniprot IdentifierRIM15_YEAST
Bait Gene NameRIM15
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position1072-1077
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20051
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16308562
CommentsPhosphorylation-dependent 14-3-3-binding site in yeast PAS kinase RIM15 (which functions as a key controller of many aspects of the quiescent G0 state) that mediates binding to BMH2 (the 14-3-3 isoform from Saccharomyces cerevisiae) thereby effectively sequestering Rim15 in the cytoplasm (dephosphorylation of the 14-3-3-binding site in Rim15, in turn, enabling nuclear import of Rim15)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)