Instance ID10061
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceKSATTT
Bait Uniprot AccessionP05107
Bait Uniprot IdentifierITB2_HUMAN
Bait Gene NameITGB2
Bait OrganismHomo sapiens (Human)
Sequence Position755-760
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; SPR; X-ray crystallography; Pull down
Interaction ID20061
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18550856
CommentsBeta2 integrin phosphorylation on cytoplasmic Thr758 acts as a molecular switch to inhibit filamin binding and allow 14-3-3 protein zeta binding to the integrin cytoplasmic domain, thereby modulating T-cell adhesion

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)