Instance ID10062
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRAVSMD
Bait Uniprot AccessionO43524
Bait Uniprot IdentifierFOXO3_HUMAN
Bait Gene NameFOXO3
Bait OrganismHomo sapiens (Human)
Sequence Position250-255
Critical ResiduesUnknown
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20062
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11864996
Comments14-3-3 binding site (pS-253) in the human proapoptotic transcription factor FKHRL1 (or FOXO3) that mediates binding to 14-3-3 protein zeta

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)