Instance ID10069
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRSPSMP
Bait Uniprot AccessionP30305
Bait Uniprot IdentifierMPIP2_HUMAN
Bait Gene NameCDC25B
Bait OrganismHomo sapiens (Human)
Sequence Position320-325
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Fluorescence technology; GFP tag; Co-IP; Mutation analysis; Western blot
Interaction ID20069
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20801879
Comments14-3-3 binding site (pS-323) in the human Dual specificity phosphatase Cdc25B, a key regulator of entry into mitosis, that mediates binding to 14-3-3 protein beta [mitotic phosphorylation of Ser321 enhances the dephosphorylation of Ser(323) to block 14-3-3 binding to this site]

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)