Instance ID10071
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRSPSMP
Bait Uniprot AccessionP30307
Bait Uniprot IdentifierMPIP3_HUMAN
Bait Gene NameCDC25C
Bait OrganismHomo sapiens (Human)
Sequence Position213-218
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Competition binding; Co-IP; Western blot; Alanine scanning
Interaction ID20071
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9278512
Comments14-3-3 binding site (pS-216) in the human Dual specificity phosphatase Cdc25C that mediates binding to 14-3-3 protein beta

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)