Instance ID10086
Regular Expression[IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM]
Motif InstanceLNEKIAQRPGPMELVEKNIL
Bait Uniprot AccessionQ8K4J6
Bait Uniprot IdentifierMKL1_MOUSE
Bait Gene NameMkl1
Bait OrganismMus musculus (Mouse)
Sequence Position105-124
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning; structure based prediction; Molecular sieving; circular dichroism; Co-IP; Colocalization; Sequence based prediction
Interaction ID20086
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18025109, 21673315, 17588931, 12732141, 19008859
CommentsRPEL motif (105-124) in mouse Myocardin-related transcription factor Mkl1 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)