Instance ID10090
Regular Expression[R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI]
Motif InstanceREQLMESIRKGKELKQI
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position464-480
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving
Interaction ID20090
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)