Instance ID10105
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceYEILMGDIRAKKYQLRKV
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position400-417
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR
Interaction ID20105
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of chicken Alpha-actin-1


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)