Instance ID10112
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceDKPDMAEIEKFDKSKLKKT
Bait Uniprot AccessionA2VCK8
Bait Uniprot IdentifierA2VCK8_HUMAN
Bait Gene NameTMSB4X
Bait OrganismHomo sapiens (Human)
Sequence Position3-21
Critical ResiduesP17; P18
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)ITC; structure based prediction; Sequence based prediction; X-ray crystallography; Mutation analysis; Cross linking studies; circular dichroism
Interaction ID20112
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16275905, 8617195
CommentsThe WH2 motif in human Thymosin beta 4 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)