Instance ID10114
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFVGFTY
Bait Uniprot AccessionQ13464
Bait Uniprot IdentifierROCK1_HUMAN
Bait Gene NameROCK1
Bait OrganismHomo sapiens (Human)
Sequence Position394-399
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Mutation analysis
Interaction ID20114
Interacting DomainPIF-binding pocket
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)18204440
CommentsPDK1 competes directly with RhoE for binding to human ROCK1 through the AGC Kinase docking motif that interacts with the PIF pocket of PDK1, thus altering the localization of ROCK1 and reducing its ability to drive cortical acto-myosin contraction

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)