Instance ID10116
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFLGFTY
Bait Uniprot AccessionP67999
Bait Uniprot IdentifierKS6B1_RAT
Bait Gene NameRps6kb1
Bait OrganismRattus norvegicus (Rat)
Sequence Position408-413
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR
Interaction ID20116
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11500365
CommentsPhosphorylation of the hydrophobic motif of p70 ribosomal S6 kinase 1 promotes its interaction with the PIF-binding pocket of PDK1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)