Instance ID10117
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFLGFSY
Bait Uniprot AccessionO00141
Bait Uniprot IdentifierSGK1_HUMAN
Bait Gene NameSGK1
Bait OrganismHomo sapiens (Human)
Sequence Position418-423
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Ser-P5
Secondary StructureUnknown
Experimental Method(s)Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR
Interaction ID20117
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11500365
CommentsPhosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk1 promotes its interaction with the PIF-binding pocket of PDK1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)