Instance ID10119
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFAGFTF
Bait Uniprot AccessionP11792
Bait Uniprot IdentifierSCH9_YEAST
Bait Gene NameSCH9
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position733-738
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Pull down; Protein kinase assay; Mutation analysis
Interaction ID20119
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21531713
CommentsInteraction of PKH1, the yeast ortholog of mammalian PDK1, with SCH9, the yeast S6K ortholog, depends on the hydrophobic PDK1-interacting fragment (PIF) pocket in PKH1 and requires the complementary hydrophobic motif in SCH9

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)